Antiphospholipid Antibodies and Thrombotic Events in COVID-19 Patients Hospitalized in Medicine Ward

Alexandre Le Joncour (1, 2, 3, 2, 2) , Corinne Frère (2) , Isabelle Martin-Toutain (2) , Paul Gougis (2) , Pascale Ghillani-Dalbin (2) , Georgina Maalouf (1, 2, 3, 2, 2) , Matheus Vieira (2, 1, 2, 3, 2) , Anne-Genevieve Marcelin (2) , Joe-Elie Salem (2, 4) , Yves Allenbach (5, 2) , David Saadoun (2, 1, 2, 3, 2) , Olivier Benveniste (5, 2) , Patrice P. Cacoub (2, 1, 2, 3, 2)

1 I3 - Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière]
2 CHU Pitié-Salpêtrière [AP-HP]
3 CIC-BTi - Centre d'investigation clinique Biothérapie [CHU Pitié-Salpêtrière]
4 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
5 Centre de recherche en Myologie – U974 SU-INSERM

This is a prospective single-center observational cohort study of COVID-19 patients admitted in the Internal Medicine and Clinical Immunology Department of a tertiary care university hospital (Paris, France). Included patients were older than 18 years with an initial requirement for hospitalization in a medical ward and a positive SARS-CoV-2 RT-PCR assay from nasal swabs. Patients were tested for the presence of aPL antibodies. Limit of positivity was fixed at 15 and 10 units/mL (99th percentile of a control population) for aCL and aβ2GPI antibodies respectively. Continuous variables are presented as median (interquartile range, IQR) and were compared using Wilcoxon’s- test. Categorical variables are presented as count (percent) and were compared using Fisher’s-test.

Mots clés: Antiphospholipid syndrome; COVID-19; Infection; Pulmonary

Domaines: Sciences du Vivant [q-bio]

Alexandre Le Joncour, Corinne Frère, Isabelle Martin-Toutain, Paul Gougis, Pascale Ghillani-Dalbin, et al.. Antiphospholipid Antibodies and Thrombotic Events in COVID-19 Patients Hospitalized in Medicine Ward. ACR Convergence 2020, Nov 2020, Online, United States. , 20 (2), pp.102729, 2021, Elsevier Public Health Emergency Collection. ⟨10.1016/j.autrev.2020.102729⟩. ⟨hal-03831591⟩