Mechanoregulation of PDZ Proteins, An Emerging Function

Elsa Bazellières (1) , André Le Bivic (1)

1 IBDM - Institut de Biologie du Développement de Marseille

Mechanical forces have emerged as essential regulators of cell organization, proliferation, migration, and polarity to regulate cellular and tissue homeostasis. Changes in forces or loss of the cellular response to them can result in abnormal embryonic development and diseases. Over the past two decades, many efforts have been put in deciphering the molecular mechanisms that convert forces into biochemical signals, allowing for the identification of many mechanotransducer proteins. Here we discuss how PDZ proteins are emerging as new mechanotransducer proteins by altering their conformations or localizations upon force loads, leading to the formation of macromolecular modules tethering the cell membrane to the actin cytoskeleton.

Mots clés: PDZ proteins; Forces; Tight junctions; Adherens junctions; Actomyosin

Domaines: Sciences du Vivant [q-bio]

Elsa Bazellières, André Le Bivic. Mechanoregulation of PDZ Proteins, An Emerging Function. Methods in Molecular Biology, 2021, pp.257 - 275. ⟨10.1007/978-1-0716-1166-1_15⟩. ⟨hal-03667726⟩