Skip to Main content Skip to Navigation
Journal articles

An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles

Abstract : Recent results comparing the temporal program of genome replication of yeast species belonging to the Lachancea clade support the scenario that the evolution of the replication timing program could be mainly driven by correlated acquisition and loss events of active replication origins. Using these results as a benchmark, we develop an evolutionary model defined as birth-death process for replication origins and use it to identify the evolutionary biases that shape the replication timing profiles. Comparing different evolutionary models with data, we find that replication origin birth and death events are mainly driven by two evolutionary pressures, the first imposes that events leading to higher double-stall probability of replication forks are penalized, while the second makes less efficient origins more prone to evolutionary loss. This analysis provides an empirically grounded predictive framework for quantitative evolutionary studies of the replication timing program.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03451843
Contributor : Gilles Fischer Connect in order to contact the contributor
Submitted on : Friday, November 26, 2021 - 4:45:48 PM
Last modification on : Friday, December 3, 2021 - 11:43:36 AM

File

elife-63542-v2.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Rossana Droghetti, Nicolas Agier, Gilles Fischer, Marco Gherardi, Marco Cosentino Lagomarsino. An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles. eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.63542⟩. ⟨hal-03451843⟩

Share

Metrics

Les métriques sont temporairement indisponibles