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Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death

Abstract : Nigratine (also known as 6E11), a flavanone derivative of a plant natural product, was characterized as highly specific non-ATP competitive inhibitor of RIPK1 kinase, one of the key components of necroptotic cell death signaling. We show here that nigratine inhibited both necroptosis (induced by Tumor Necrosis Factor-α) and ferroptosis (induced by the small molecules glutamate, erastin, RSL3 or cumene hydroperoxide) with EC 50 in the µM range. Taken together, our data showed that nigratine is a dual inhibitor of necroptosis and ferroptosis cell death pathways. These findings open potential new therapeutic avenues for treating complex necrosis-related diseases.
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https://hal.sorbonne-universite.fr/hal-03624406
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Submitted on : Wednesday, March 30, 2022 - 11:38:51 AM
Last modification on : Thursday, August 4, 2022 - 5:14:34 PM

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Claire Delehouzé, Arnaud Comte, Stephen Leon-Icaza, Céline Cougoule, Marcelle Hauteville, et al.. Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death. Scientific Reports, Nature Publishing Group, 2022, 12, pp.5118. ⟨10.1038/s41598-022-09019-w⟩. ⟨hal-03624406⟩

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