Skip to Main content Skip to Navigation
Journal articles

GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch

Abstract : The GABA response switch from excitatory to inhibitory is a key event in neuronal maturation that depends on the regulated expression of chloride transporters NKCC1 and KCC2. In this issue, Lee et al. (2020. J. Cell. Biol.https://doi.org/10.1083/jcb.201903033 ) describe how degradation of NKCC1 by proteasomes immobilized at the axon initial segment (AIS) by the Ecm29 adaptor contributes to this regulation, driving the GABA switch and the positional maturation of the AIS.
Document type :
Journal articles
Complete list of metadatas

Cited literature [9 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-02439594
Contributor : Christophe Leterrier <>
Submitted on : Tuesday, January 14, 2020 - 4:29:59 PM
Last modification on : Thursday, January 16, 2020 - 1:38:36 AM
Long-term archiving on: : Wednesday, April 15, 2020 - 8:07:49 PM

File

2020_The Journal of Cell Biolo...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - NonCommercial - ShareAlike 4.0 International License

Identifiers

Collections

Citation

Christophe Leterrier. GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch. Journal of Cell Biology, Rockefeller University Press, 2020, 219 (2), ⟨10.1083/jcb.201912006⟩. ⟨hal-02439594⟩

Share

Metrics

Record views

91

Files downloads

123