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, Conclusion et Perspectives Introduction Les adénovirus sont des virus à ADN bicaténaire linéaire, non enveloppés, à capside icosaédrique, appartenant à la famille des Adenoviridae. Ils sont responsables d'un grand nombre d'infections (gastroentérites, conjonctivites, etc), dont certaines pouvant être sévères chez la personne immunodéprimée. Le diagnostic actuel se fait par PCR, la culture virale reste un outil clé pour la détection et la caractérisation des différentes souches
, Récemment nous avons développé une nouvelle méthode d'isolement et de détection des virus basée sur la culture virale et couplée à la microscopie haut débit
, La microscopie High Content Screening (HCS) consiste en l'acquisition d'images par le microscope, puis l'analyse des datas générées par l'appareil et le développement d'algorithmes permettant l'analyse des échantillons à grande échelle. L'objectif de ce travail a été la mise au point de cette nouvelle technique de détection automatisée de la réplication en culture