Z. Reactions, J. Bienaymé, H. Wiley-vch, W. Bienaymé, H. Hulme et al., For some recent reviews on MCRs, see: (b) Dömling , A 17, and references cited there in (d) Domling, A.; Ugi, I For representative reviews, see: (h) Tietze, L. F Synthesis, ) Schreiber, S. L. Science) (a) Trost, B. M. Science, pp.3321-3168, 1133.

R. D. Hubbard, M. J. Scanio, R. Sun, T. J. Williams, L. Zhang et al., For a special issue in environmental chemistry, see) For recent reviews, Targets in Heterocyclic Systems Studies in Naturel Products Chemistry, pp.25-143, 1671.

C. , E. Filippini, M. H. Rodriguez, and J. Synthesis, mmol) and DBU (3 mmol) in appropriate solvant (4 mL, table 1) was added the corresponding aldehyde 2 (1.1 mmol) and halide 3 (2 mmol) The resulting solution was stirred for the indicated time and temperature (table 1) After completion and evaporation of most of the solvent under reduced pressure, 1N solution of HCl (30 mL) was added to the oily residue Extraction with Et 2 O (3 x 40 mL) followed by successive washing with distilled water (2 x 20 mL) and brine (20 mL) gave, after drying (MgSO 4 ) and evaporation of the solvent, the crude compounds which were purified by flash chromatography on silica gel. Physical data for compound 4b: Yellow oil; R f (dietyl ether 50 / petroleum ether 50) = 0.79; IR (liquid film), 15) General Procedure for MCRs MS : m/z (%) = [M+H + ] 305 (100)1H, d, J = 3.5 Hz), 6.53 (1H, dd, J = 3.5, 1.5 Hz)1H, dd, J = 13.8, 7.1 Hz)1H, dd, J = 13.8, 7.6 Hz). 13 C NMR, pp.788-927, 1133.

). A. Fürstner, K. Langemann, J. Am, J. Cossy, D. Bauer et al., General procedure for RCMs: To a 6x10 -3 M solution of spiro-heterocyclic precursors 4a-4e in dry CH 2 Cl 2 , under atmosphere of argon, the Grubbs catalyst 5b was introduced in several portions of 2% every 2 hours. The mixture was stirred at reflux and completion of reaction checked by TLC. The mixture was filtered through a pad of silica gel and celite and the crude material was purified by flash chromatography on silica gel. Physical data for compound 6c: Yellow solid, Chem. Soc. Tetrahedron Lett. Tetrahedron Lett J. Am. Chem. Soc, vol.119300, issue.11917100175, pp.9130-4187, 1201.

R. F. Heck, In Vinyl Substitution with Organopalladium Intermediates in Comprehensive Organic Synthesis, Pergamon: Oxford, vol.4, 1991.

J. P. Wolfe, S. Wagaw, S. L. Buchwald, B. H. Yang, S. L. Buchwald et al., General procedure for Heck reaction: To a 4x10 -2 M solution of spiro-heterocyclic precursors 4f and 4g in dry acetonitrile, under atmosphere of argon, palladium acetate (4 equiv) and triphenylphosphine (8 equiv) were added, followed by triethylamine (1.2 equiv) The mixture was stirred at reflux and completion of reaction checked by TLC. The mixture was filtered through a pad of celite and the crude material was purified by flash chromatography on silica gel. Physical data for compound 7b: Yellow powder mp = 169-171°C; IR (liquid film): 2926, J. Am. Chem. Soc, vol.118300, issue.1, pp.35-940, 1256.