Consecutive Reactions with Sulfoximines: Straightforward Synthesis of Substituted 5,5-Spiroketals
Résumé
An efficient sysnthesis of 5,5-spiroketals, i.e. 1,6-dioxaspiro[4.4]nonane derivatives, is described from 2-(sulfonimidoylmethylene)tetrahydrofurans involving a consecutive epoxide opening / oxa-Michael spiroketalization sequence. This methodology was applied to the very direct synthesis of chalcogran, a beetle pheromone.
Domaines
Chimie organique
Origine : Fichiers produits par l'(les) auteur(s)
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