Synthetic Studies Towards Guaianolide Sesquiterpene Lactones

Isabelle Reboul (1) , Thomas Boddaert (1) , Yoann Coquerel (1) , Jean Rodriguez (1)

1 STeRéO

A promising synthetic route towards bioactive guaianolide sesquiterpene lactones is presented. The strategy is based on a recently invented multicomponent reaction (MARDi cascade) and subsequent highly chemoselective and domino transformations for the expeditious stereoselective preparation of the tricyclic core of the natural products.

Mots clés: Chemoselectivity; Domino reaction; Guaianolides; Multicomponent reactions; Natural products

Domaines: Chimie organique

Isabelle Reboul, Thomas Boddaert, Yoann Coquerel, Jean Rodriguez. Synthetic Studies Towards Guaianolide Sesquiterpene Lactones. European Journal of Organic Chemistry, 2008, pp.5379-5382. ⟨10.1002/ejoc.200800825⟩. ⟨hal-00678253⟩