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Straightforward one-pot stereoselective synthesis of substituted tetrahydrofurans from 1,3-butadienes and aldehydes.

Maryline Roux Chahinez Aouf Jean-Luc Parrain 1, * Maurice Santelli * 
* Corresponding author
1 STeRéO
ISM2 - Institut des Sciences Moléculaires de Marseille
Abstract : A new and efficient multicomponent reaction involving a double-allylation sequence is reported. In situ generated bimetallic reagents are prepared from disilane and added onto a range of aliphatic aldehydes to afford a direct access to trisubstituted tetrahydrofurans in good to excellent diastereoselectivity (up to 70%).
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Maryline Roux, Chahinez Aouf, Jean-Luc Parrain, Maurice Santelli. Straightforward one-pot stereoselective synthesis of substituted tetrahydrofurans from 1,3-butadienes and aldehydes.. Tetrahedron Letters, Elsevier, 2007, 48, pp.4011-4014. ⟨10.1016/j.tetlet.2007.04.034⟩. ⟨hal-00679642⟩

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