Stereoselective Synthesis of the Core of Naturally Occurring Anti-HIV Isolitseane B

Paul Brémond (1) , Elodie Girardeau (1) , Yoann Coquerel (1) , Jean Rodriguez (1)

1 STeRéO

A key intermediate in the total synthesis of naturally occurring anti-HIV Isolitseane B has been prepared in five steps from propargyl alcohol, featuring a highly selective mono-transacetalization and a stereoselective Pauson-Khand cyclization.

Mots clés: Acetal; Pauson-Khand; anti-HIV; total synthesis; natural products

Domaines: Chimie organique

Paul Brémond, Elodie Girardeau, Yoann Coquerel, Jean Rodriguez. Stereoselective Synthesis of the Core of Naturally Occurring Anti-HIV Isolitseane B. Letters in Organic Chemistry, 2007, 4, pp.232-233. ⟨hal-00681031⟩