Highly Efficient Access to Original Polycyclic Pyrrolopiperazine Scaffolds by a Three-Component Reaction with 1,3-Dicarbonyls.

Frédéric Liéby-Müller (1) , Thierry Constantieux (2) , Jean Rodriguez (1)

1 STeRéO
2 ISM2 - Institut des Sciences Moléculaires de Marseille

Molecular sieves have been found to promote a new fast, environmentally friendly and experimentally simple mul- ticomponent domino reaction from 1,3-dicarbonyls for the synthe- sis of pyrrolopiperazine and azasteroid-like scaffolds, of potential synthetic and biological interests.

Mots clés: multicomponent reaction; atom economy; pyrrolopiperazine; 3-dicarbonyls; molecular sieves; heterogeneous catalysis

Domaines: Chimie organique

Frédéric Liéby-Müller, Thierry Constantieux, Jean Rodriguez. Highly Efficient Access to Original Polycyclic Pyrrolopiperazine Scaffolds by a Three-Component Reaction with 1,3-Dicarbonyls.. SYNLETT, 2007, pp.1323-1325. ⟨10.1055/s-2007-973906⟩. ⟨hal-00681078⟩