Skip to Main content Skip to Navigation
Journal articles

Microwave-Assisted Domino Benzannulation of α-Oxo Ketenes: Preparation of 1,3-Dihydro-2H-1,5-benzodiazepin-2-ones

Juan-Carlos Castillo 1 Marc Presset 2 Rodrigo Abonia 1 Yoann Coquerel 2, * Jean Rodriguez 2 
* Corresponding author
2 STeRéO
ISM2 - Institut des Sciences Moléculaires de Marseille
Abstract : The microwave irradiation of a series of 2-diazo-1,3-diket- ones in the presence of an o-phenylenediamine derivative triggered a domino Wolff rearrangement/nucleophilic addition/intramolecular imination sequence to provide a new synthetic entry to 1,3-dihydr-2H-1,5-benzodiazepin-2-ones, a class of molecules with important biological properties.
Document type :
Journal articles
Complete list of metadata
Contributor : Gaelle Chouraqui Connect in order to contact the contributor
Submitted on : Friday, June 1, 2012 - 2:37:29 PM
Last modification on : Tuesday, December 14, 2021 - 8:36:10 AM

Links full text




Juan-Carlos Castillo, Marc Presset, Rodrigo Abonia, Yoann Coquerel, Jean Rodriguez. Microwave-Assisted Domino Benzannulation of α-Oxo Ketenes: Preparation of 1,3-Dihydro-2H-1,5-benzodiazepin-2-ones. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2012, pp.2338-2345. ⟨10.1002/ejoc.201200093⟩. ⟨hal-00703287⟩



Record views