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A convergent Approach based on local symmetry en route to (-)-Callystatin

Mathieu Candy 1 Loïc Tomas 1 Sabrina Parat 1 Virginie Héran 1 Hugues Bienaymé Jean-Marc Pons 1, * Cyril Bressy 1, * 
* Corresponding author
1 STeRéO
ISM2 - Institut des Sciences Moléculaires de Marseille
Abstract : A convergent synthetic approach of the highly cytotoxic natural product (−)-callystatin A was developed assembling three fragments through Julia-Kocienski olefination and Stille cross-coupling. The new strategy relies on a pivotal local symmetry of the target molecule. In this preliminary study, particular attention was devoted to facilitate the catalytic enantiocontrol of strategic stereogenic centers present in each of the fragments.
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https://hal.archives-ouvertes.fr/hal-00747371
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Submitted on : Wednesday, October 31, 2012 - 10:57:29 AM
Last modification on : Tuesday, December 14, 2021 - 8:36:12 AM

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Mathieu Candy, Loïc Tomas, Sabrina Parat, Virginie Héran, Hugues Bienaymé, et al.. A convergent Approach based on local symmetry en route to (-)-Callystatin. Chemistry - A European Journal, Wiley-VCH Verlag, 2012, 18, pp.14267-14271. ⟨10.1002/chem.201202701⟩. ⟨hal-00747371⟩

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