Skip to Main content Skip to Navigation
Journal articles

A convergent Approach based on local symmetry en route to (-)-Callystatin

Mathieu Candy 1 Loïc Tomas 1 Sabrina Parat 1 Virginie Héran 1 Hugues Bienaymé Jean-Marc Pons 1, * Cyril Bressy 1, * 
* Corresponding author
1 STeRéO
ISM2 - Institut des Sciences Moléculaires de Marseille
Abstract : A convergent synthetic approach of the highly cytotoxic natural product (−)-callystatin A was developed assembling three fragments through Julia-Kocienski olefination and Stille cross-coupling. The new strategy relies on a pivotal local symmetry of the target molecule. In this preliminary study, particular attention was devoted to facilitate the catalytic enantiocontrol of strategic stereogenic centers present in each of the fragments.
Document type :
Journal articles
Complete list of metadata
Contributor : Gaelle Chouraqui Connect in order to contact the contributor
Submitted on : Wednesday, October 31, 2012 - 10:57:29 AM
Last modification on : Tuesday, December 14, 2021 - 8:36:12 AM

Links full text




Mathieu Candy, Loïc Tomas, Sabrina Parat, Virginie Héran, Hugues Bienaymé, et al.. A convergent Approach based on local symmetry en route to (-)-Callystatin. Chemistry - A European Journal, Wiley-VCH Verlag, 2012, 18, pp.14267-14271. ⟨10.1002/chem.201202701⟩. ⟨hal-00747371⟩



Record views