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Article Dans Une Revue PLoS ONE Année : 2013

Afghan hindu kush: where eurasian sub-continent gene flows converge

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Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pakistani samples (HGDP-CEPH). The data presented here was integrated into existing knowledge of pan-Eurasian genetic diversity. The pattern of genetic variation, revealed by structure-like and Principal Component analyses and Analysis of Molecular Variance indicates that the people of Afghanistan are made up of a mosaic of components representing various geographic regions of Eurasian ancestry. The absence of a major Central Asian-specific component indicates that the Hindu Kush, like the gene pool of Central Asian populations in general, is a confluence of gene flows rather than a source of distinctly autochthonous populations that have arisen in situ: a conclusion that is reinforced by the phylogeography of both haploid loci.
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hal-00903448 , version 1 (19-09-2018)

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Julie Di Cristofaro, Erwan Pennarun, Stéphane Mazières, Natalie M Myres, Alice A Lin, et al.. Afghan hindu kush: where eurasian sub-continent gene flows converge. PLoS ONE, 2013, 8 (10), pp.e76748. ⟨10.1371/journal.pone.0076748⟩. ⟨hal-00903448⟩
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