An Iron/Amine-Catalyzed Cascade Process for the Enantioselective Functionalization of Allylic Alcohols

Adrien Quintard (1) , Thierry Constantieux (1) , Jean Rodriguez (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

An enantioselective transformation of allylic alcohols into β-chiral saturated alcohols has been developed by combining two distinct metal- and organocatalyzed catalytic cycles. This waste-free triple cascade process merges an iron-catalyzed borrowing-hydrogen step with an aminocatalyzed nucleophilic addition

Mots clés: asymmetric catalysis; dual catalysis; hydrogen transfer; iron; organocatalysis

Domaines: Chimie organique

Adrien Quintard, Thierry Constantieux, Jean Rodriguez. An Iron/Amine-Catalyzed Cascade Process for the Enantioselective Functionalization of Allylic Alcohols. Angewandte Chemie International Edition, 2013, 52, pp.12883-12887. ⟨10.1002/anie.201307295⟩. ⟨hal-01133519⟩