A. N. Akopian, N. B. Ruparel, N. A. Jeske, and K. M. Hargreaves, Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization, The Journal of Physiology, vol.10, issue.1, pp.175-193, 2007.
DOI : 10.1113/jphysiol.2007.133231

R. Amir and M. Devor, Chemically mediated cross-excitation in rat dorsal root ganglia, J. Neurosci, vol.16, pp.4733-4741, 1996.

A. Bajaj, N. E. Laplante, V. E. Cotero, K. M. Fish, R. M. Bjerke et al., Identification of the Protein Target of Myelin-Binding Ligands by Immunohistochemistry and Biochemical Analyses, Journal of Histochemistry & Cytochemistry, vol.2011, issue.1, pp.19-30, 1369.
DOI : 10.1523/JNEUROSCI.4082-08.2009

M. D. Baker and S. Waxman, Sodium channel slow inactivation and adaptation in C-fibres, The Journal of Physiology, vol.72, issue.7, pp.1513-1514, 2012.
DOI : 10.1113/jphysiol.2011.224436

S. Benemei, C. Fusi, G. Trevisan, and P. Geppetti, The TRPA1 channel in migraine mechanism and treatment, British Journal of Pharmacology, vol.400, issue.Suppl 2, pp.2552-2567, 2014.
DOI : 10.1111/bph.12512

L. Chiossi, A. Negro, M. Capi, L. Lionetto, and P. Martelletti, Sodium channel antagonists for the treatment of migraine, Expert Opinion on Pharmacotherapy, vol.13, issue.5, pp.1697-1706, 2014.
DOI : 10.1111/j.1468-2982.2007.01326.x

M. Costigan, J. Scholz, and C. J. Woolf, Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage, Annual Review of Neuroscience, vol.32, issue.1, 2009.
DOI : 10.1146/annurev.neuro.051508.135531

D. Col, R. Messlinger, K. Carr, and R. W. , Repetitive activity slows axonal conduction velocity and concomitantly increases mechanical activation threshold in single axons of the rat cranial dura, The Journal of Physiology, vol.19, issue.4, pp.725-736, 2012.
DOI : 10.1113/jphysiol.2011.220624

G. Dussor, J. Yan, J. Y. Xie, M. H. Ossipov, D. W. Dodick et al., Targeting TRP Channels For Novel Migraine Therapeutics, ACS Chemical Neuroscience, vol.5, issue.11, pp.1085-1096, 2012.
DOI : 10.1021/cn500083e
URL : http://doi.org/10.1021/cn500083e

E. Fabbretti, M. D-'arco, A. Fabbro, M. Simonetti, A. Nistri et al., Delayed Upregulation of ATP P2X3 Receptors of Trigeminal Sensory Neurons by Calcitonin Gene-Related Peptide, Journal of Neuroscience, vol.26, issue.23, pp.6163-6171, 2006.
DOI : 10.1523/JNEUROSCI.0647-06.2006

M. S. Fee, P. P. Mitra, and D. Kleinfeld, Automatic sorting of multiple unit neuronal signals in the presence of anisotropic and non-Gaussian variability, Journal of Neuroscience Methods, vol.69, issue.2, pp.175-188, 1996.
DOI : 10.1016/S0165-0270(96)00050-7

L. F. Ferrari, D. Araldi, and J. D. Levine, Distinct Terminal and Cell Body Mechanisms in the Nociceptor Mediate Hyperalgesic Priming, Journal of Neuroscience, vol.35, issue.15, pp.6107-6116, 2015.
DOI : 10.1523/JNEUROSCI.5085-14.2015

S. E. Flowerdew, D. Wick, S. Himmelein, A. K. Horn, I. Sinicina et al., Characterization of Neuronal Populations in the Human Trigeminal Ganglion and Their Association with Latent Herpes Simplex Virus-1 Infection, PLoS ONE, vol.1762, issue.12, 2013.
DOI : 10.1371/journal.pone.0083603.s005

R. Giniatullin, A. Nistri, and E. Fabbretti, Molecular Mechanisms of Sensitization of Pain-transducing P2X3 Receptors by the Migraine Mediators CGRP and NGF, Molecular Neurobiology, vol.350, issue.Suppl 1, pp.83-90, 2008.
DOI : 10.1007/s12035-008-8020-5

P. J. Goadsby, Recent advances in understanding migraine mechanisms, molecules and therapeutics, Trends in Molecular Medicine, vol.13, issue.1, pp.39-44, 2007.
DOI : 10.1016/j.molmed.2006.11.005

J. J. Ivanusic, K. E. Goulding, M. M. Kwok, J. , and E. A. , Neurochemical classification and projection targets of CART peptide immunoreactive neurons in sensory and parasympathetic ganglia of the head, Neuropeptides, vol.46, issue.1, pp.55-60, 2012.
DOI : 10.1016/j.npep.2011.09.002

A. Jara-oseguera, S. A. Simon, and T. Rosenbaum, TRPV1: On the Road to Pain Relief, Current Molecular Pharmacology, vol.1, issue.3, pp.255-269, 2008.
DOI : 10.2174/1874467210801030255

D. Johnston and S. M. Wu, Foundations of Cellular Neurophysiology, 1995.

J. Joseph, S. Wang, J. Lee, J. Y. Ro, C. et al., Carboxyl-terminal Domain of Transient Receptor Potential Vanilloid 1 Contains Distinct Segments Differentially Involved in Capsaicin- and Heat-induced Desensitization, Journal of Biological Chemistry, vol.288, issue.50, pp.35690-35702, 2013.
DOI : 10.1074/jbc.M113.513374

D. Julius and A. I. Basbaum, Molecular mechanisms of nociception, Nature, vol.413, issue.6852, pp.203-210, 2001.
DOI : 10.1038/35093019

S. N. Kadir, D. F. Goodman, H. , and K. D. , High-Dimensional Cluster Analysis with the Masked EM Algorithm, Neural Computation, vol.84, issue.1, pp.2379-2394, 2014.
DOI : 10.1016/j.jneumeth.2008.04.030

R. H. Lamotte, L. E. Lundberg, and H. E. Torebjörk, Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin Phenotype and function of somatic primary afferent nociceptive neurones with C-, A?-or A?/?-fibres Migraine pain and nociceptor activation?where do we stand?, J. Physiol. Exp. Physiol. Headache, vol.448, issue.50, pp.749-764, 1992.

M. Mazzuca, M. Minlebaev, A. Shakirzyanova, R. Tyzio, G. Taccola et al., Newborn Analgesia Mediated by Oxytocin during Delivery, Frontiers in Cellular Neuroscience, vol.5, 2011.
DOI : 10.3389/fncel.2011.00003

K. Messlinger, Migraine: where and how does the pain originate?, Experimental Brain Research, vol.27, issue.Suppl 1, pp.179-193, 2009.
DOI : 10.1007/s00221-009-1756-y

S. L. Morales-lázaro, S. A. Simon, and T. Rosenbaum, The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1), The Journal of Physiology, vol.400, issue.13, pp.3109-3121, 2013.
DOI : 10.1113/jphysiol.2013.251751

M. M. Moran, M. A. Mcalexander, T. Bíró, and A. Szallasi, Transient receptor potential channels as therapeutic targets, Nature Reviews Drug Discovery, vol.5, issue.8, pp.601-620, 2011.
DOI : 10.1038/nrd3456

E. D. Por, S. M. Bierbower, K. A. Berg, R. Gomez, A. N. Akopian et al., ??-Arrestin-2 Desensitizes the Transient Receptor Potential Vanilloid 1 (TRPV1) Channel, Journal of Biological Chemistry, vol.287, issue.44, pp.37552-37563, 2012.
DOI : 10.1074/jbc.M112.391847

L. S. Premkumar, Targeting TRPV1 as an Alternative Approach to Narcotic Analgesics to Treat Chronic Pain Conditions, The AAPS Journal, vol.12, issue.3, 2010.
DOI : 10.1208/s12248-010-9196-y

M. M. Salas, K. M. Hargreaves, and A. N. Akopian, TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1, European Journal of Neuroscience, vol.10, issue.8, 2009.
DOI : 10.1111/j.1460-9568.2009.06702.x

M. Schueler, K. Messlinger, M. Dux, W. L. Neuhuber, D. Col et al., Extracranial projections of meningeal afferents and their impact on meningeal nociception and headache, Pain, vol.154, issue.9, pp.1622-1631, 2013.
DOI : 10.1016/j.pain.2013.04.040

M. Schueler, W. L. Neuhuber, R. De-col, and K. Messlinger, Innervation of Rat and Human Dura Mater and Pericranial Tissues in the Parieto-Temporal Region by Meningeal Afferents, Headache: The Journal of Head and Face Pain, vol.36, issue.Suppl. 1, pp.996-1009, 2014.
DOI : 10.1111/head.12371

A. Shatillo, K. Koroleva, R. Giniatullina, N. Naumenko, A. A. Slastnikova et al., Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system, Neuroscience, vol.253, pp.341-349, 2013.
DOI : 10.1016/j.neuroscience.2013.09.002

M. Simonetti, A. Fabbro, M. D-'arco, M. Zweyer, A. Nistri et al., Comparison of P2X and TRPV1 Receptors in Ganglia or Primary Culture of Trigeminal Neurons and their Modulation by NGF or Serotonin, Molecular Pain, vol.17, issue.4, pp.11-21, 2006.
DOI : 10.1038/39807

M. Simonetti, R. Giniatullin, and E. Fabbretti, Mechanisms mediating the enhanced gene transcription of P2X 3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons, J. Biol. Chem, vol.283, pp.18742-18752, 2008.

B. Storti, C. Di-rienzo, F. Cardarelli, R. Bizzarri, and F. Beltram, Unveiling TRPV1 Spatio-Temporal Organization in Live Cell Membranes, PLOS ONE, vol.96, issue.3, 2015.
DOI : 10.1371/journal.pone.0116900.s008

A. M. Strassman and D. Levy, Response Properties of Dural Nociceptors in Relation to Headache, Journal of Neurophysiology, vol.95, issue.3, 2005.
DOI : 10.1152/jn.01293.2005

S. Thalakoti, V. V. Patil, S. Damodaram, C. V. Vause, L. E. Langford et al., Neuron?Glia Signaling in Trigeminal Ganglion: Implications for Migraine Pathology, Headache: The Journal of Head and Face Pain, vol.58, issue.7, pp.1008-1023, 2007.
DOI : 10.1111/j.1526-4610.2004.04094.x

C. K. Tong and A. B. Macdermott, Synaptic GluN2A and GluN2B Containing NMDA Receptors within the Superficial Dorsal Horn Activated following Primary Afferent Stimulation, Journal of Neuroscience, vol.34, issue.33, pp.10808-10820, 2014.
DOI : 10.1523/JNEUROSCI.0145-14.2014

M. Uebner, R. W. Carr, K. Messlinger, D. Col, and R. , Activity-dependent sensory signal processing in mechanically responsive slowly conducting meningeal afferents, Journal of Neurophysiology, vol.112, issue.12, pp.3077-3085, 2014.
DOI : 10.1152/jn.00243.2014

G. Y. Wong and N. R. Gavva, Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks, Brain Research Reviews, vol.60, issue.1, 2009.
DOI : 10.1016/j.brainresrev.2008.12.006

R. Zhang, M. Tomida, Y. Katayama, and Y. Kawakami, Response durations encode nociceptive stimulus intensity in the rat medial prefrontal cortex, Neuroscience, vol.125, issue.3, 2004.
DOI : 10.1016/j.neuroscience.2004.01.055

J. Zhao and D. Levy, The sensory innervation of the calvarial periosteum is nociceptive and contributes to headache-like behavior, Pain, vol.155, issue.7, 2014.
DOI : 10.1016/j.pain.2014.04.019