A. James, M. Knuiman, M. Divitini, J. Hui, M. Hunter et al., Changes in the prevalence of asthma in adults since 1966: the Busselton health study, European Respiratory Journal, vol.35, issue.2, pp.273-278, 2010.
DOI : 10.1183/09031936.00194308

E. Von-mutius and D. Vercelli, Farm living: effects on childhood asthma and allergy, Nature Reviews Immunology, vol.113, issue.12, pp.861-868, 2010.
DOI : 10.1038/nri2871

W. Eder, M. Ege, and E. Von-mutius, The Asthma Epidemic, New England Journal of Medicine, vol.355, issue.21, pp.2226-2235, 2006.
DOI : 10.1056/NEJMra054308

C. Braun-fahrlander, J. Riedler, U. Herz, W. Eder, M. Waser et al., Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children, New England Journal of Medicine, vol.347, issue.12, pp.869-877, 2002.
DOI : 10.1056/NEJMoa020057

J. Riedler, C. Braun-fahrländer, W. Eder, M. Schreuer, M. Waser et al., Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey, The Lancet, vol.358, issue.9288, pp.1129-11597666, 2001.
DOI : 10.1016/S0140-6736(01)06252-3

J. Sordillo, E. Hoffman, J. Celedón, A. Litonjua, D. Milton et al., Multiple microbial exposures in the home may protect against asthma or allergy in childhood, Clinical & Experimental Allergy, vol.203, issue.6, pp.902-910, 2010.
DOI : 10.1111/j.1365-2222.2010.03509.x

E. Chrischilles, R. Ahrens, A. Kuehl, K. Kelly, P. Thorne et al., Asthma prevalence and morbidity among rural Iowa schoolchildren???, Journal of Allergy and Clinical Immunology, vol.113, issue.1, pp.66-71, 2004.
DOI : 10.1016/j.jaci.2003.09.037

M. Ege, R. Frei, C. Bieli, D. Schram-bijkerk, M. Waser et al., Not all farming environments protect against the development of asthma and wheeze in children, Journal of Allergy and Clinical Immunology, vol.119, issue.5, pp.1140-1147, 2007.
DOI : 10.1016/j.jaci.2007.01.037

J. Merchant, A. Naleway, E. Svendsen, K. Kelly, L. Burmeister et al., Asthma and Farm Exposures in a Cohort of Rural Iowa Children, Environmental Health Perspectives, vol.113, issue.3, pp.350-356, 2005.
DOI : 10.1289/ehp.7240

M. Ege, M. Mayer, K. Schwaiger, J. Mattes, G. Pershagen et al., Environmental bacteria and childhood asthma, Allergy, vol.67, issue.12, pp.1565-71, 2012.
DOI : 10.1111/all.12028

M. Ege, M. Mayer, A. Normand, J. Genuneit, W. Cookson et al., Exposure to Environmental Microorganisms and Childhood Asthma, New England Journal of Medicine, vol.364, issue.8, pp.701-709, 2011.
DOI : 10.1056/NEJMoa1007302

J. Genuneit, G. Buchele, M. Waser, K. Kovacs, A. Debinska et al., The GABRIEL Advanced Surveys: study design, participation and evaluation of bias, Paediatric and Perinatal Epidemiology, vol.364, issue.5, pp.436-447, 2011.
DOI : 10.1111/j.1365-3016.2011.01223.x

D. Schram-bijkerk, G. Doekes, J. Douwes, M. Boeve, J. Riedler et al., Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.113, issue.1, pp.1272-1278, 2005.
DOI : 10.1056/NEJM199501193320301

G. Muyzer, E. De-waal, and A. Uitterlinden, Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA, Appl Environ Microbiol, vol.59, issue.3, pp.695-700, 1993.

A. Lotz, B. Kendzia, K. Gawrych, M. Lehnert, T. Brüning et al., Statistical methods for the analysis of left-censored variables, GMS Medizinische Informatik, Biometrie und Epidemiologie, vol.9, issue.2, 2013.

J. Lubin, J. Colt, D. Camann, S. Davis, J. Cerhan et al., Epidemiologic Evaluation of Measurement Data in the Presence of Detection Limits, Environmental Health Perspectives, vol.112, issue.17, pp.1691-1696, 2004.
DOI : 10.1289/ehp.7199

O. Dilly, J. Bloem, A. Vos, and J. Munch, Bacterial Diversity in Agricultural Soils during Litter Decomposition, Applied and Environmental Microbiology, vol.70, issue.1, pp.468-474, 2004.
DOI : 10.1128/AEM.70.1.468-474.2004

Y. Benjamini and Y. Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B, vol.57, issue.1, pp.289-300, 1995.

N. Boon, W. Windt, W. Verstraete, and E. Top, Evaluation of nested PCR???DGGE (denaturing gradient gel electrophoresis) with group-specific 16S rRNA primers for the analysis of bacterial communities from different wastewater treatment plants, FEMS Microbiology Ecology, vol.39, issue.2, pp.101-112, 2002.
DOI : 10.1016/S0168-6496(01)00198-2

T. Lumley and . Survey, Analysis of complex survey samples " . R package version 3, pp.22-23

T. Lumley, Analysis of Complex Survey Samples, Journal of Statistical Software, vol.9, issue.8, pp.1-19, 2004.
DOI : 10.18637/jss.v009.i08

P. Karkkainen, M. Valkonen, A. Hyvarinen, A. Nevalainen, and H. Rintala, Determination of bacterial load in house dust using qPCR, chemical markers and culture, Journal of Environmental Monitoring, vol.16, issue.5, pp.759-768, 2010.
DOI : 10.1093/nar/gkn879

S. Eisenberg, M. Nielen, W. Santema, D. Houwers, D. Heederik et al., Detection of spatial and temporal spread of Mycobacterium avium subsp. paratuberculosis in the environment of a cattle farm through bio-aerosols, Veterinary Microbiology, vol.143, issue.2-4, 2010.
DOI : 10.1016/j.vetmic.2009.11.033

S. Lynch, R. Wood, H. Boushey, L. Bacharier, G. Bloomberg et al., Effects of early-life exposure to allergens and bacteria on??recurrent wheeze and atopy in urban children, Journal of Allergy and Clinical Immunology, vol.134, issue.3, pp.593-601, 2014.
DOI : 10.1016/j.jaci.2014.04.018

R. Frei, R. Lauener, R. Crameri, O. Mahony, and L. , Microbiota and dietary interactions - an update to the hygiene hypothesis?, Allergy, vol.13, issue.Suppl, pp.451-461, 2012.
DOI : 10.1111/j.1398-9995.2011.02783.x

G. Wlasiuk and D. Vercelli, The farm effect, or, Current Opinion in Allergy and Clinical Immunology, vol.12, issue.5, pp.461-466, 2012.
DOI : 10.1097/ACI.0b013e328357a3bc

D. Heederik and E. Von-mutius, Does diversity of environmental microbial exposure matter for the occurrence of allergy and asthma?, Journal of Allergy and Clinical Immunology, vol.130, issue.1, pp.44-50, 2012.
DOI : 10.1016/j.jaci.2012.01.067

I. Hanski, L. Von-hertzen, N. Fyhrquist, K. Koskinen, K. Torppa et al., Environmental biodiversity, human microbiota, and allergy are interrelated, Proceedings of the National Academy of Sciences, vol.109, issue.21, pp.8334-8339
DOI : 10.1073/pnas.1205624109
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361383

M. Taubel, H. Rintala, M. Pitkaranta, L. Paulin, S. Laitinen et al., The occupant as a source of house dust bacteria, Journal of Allergy and Clinical Immunology, vol.124, issue.4, pp.834-874, 2009.
DOI : 10.1016/j.jaci.2009.07.045

M. Waser, R. Schierl, E. Von-mutius, S. Maisch, D. Carr et al., Determinants of endotoxin levels in living environments of farmers' children and their peers from rural areas, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.9, issue.1, pp.389-397, 2004.
DOI : 10.1202/0002-8894(1987)048<0745:ASOTRB>2.0.CO;2