Dynamic subcellular localization of a respiratory complex controls bacterial respiration - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue eLife Année : 2015

Dynamic subcellular localization of a respiratory complex controls bacterial respiration

Résumé

Respiration, an essential process for most organisms, has to optimally respond to changes in the metabolic demand or the environmental conditions. The branched character of their respiratory chains allows bacteria to do so by providing a great metabolic and regulatory flexibility. Here, we show that the native localization of the nitrate reductase, a major respiratory complex under anaerobiosis in Escherichia coli, is submitted to tight spatiotemporal regulation in response to metabolic conditions via a mechanism using the transmembrane proton gradient as a cue for polar localization. These dynamics are critical for controlling the activity of nitrate reductase, as the formation of polar assemblies potentiates the electron flux through the complex. Thus, dynamic subcellular localization emerges as a critical factor in the control of respiration in bacteria.
Fichier principal
Vignette du fichier
ptpmcrender.pdf (1.31 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01203080 , version 1 (22-09-2015)

Identifiants

Citer

François Alberge, Leon Espinosa, Farida Seduk, Léa Sylvi, René Toci, et al.. Dynamic subcellular localization of a respiratory complex controls bacterial respiration. eLife, 2015, ⟨10.7554/eLife.05357.017⟩. ⟨hal-01203080⟩

Collections

CNRS UNIV-AMU
79 Consultations
205 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More