Unraveling the therapeutic potential of the Hedgehog pathway in cancer, Nature Medicine, vol.31, issue.11, pp.1410-1422, 2013. ,
DOI : 10.1002/mpo.10121
Pancreatic stellate cells: a starring role in normal and diseased pancreas, Frontiers in Physiology, vol.3, p.344, 2012. ,
DOI : 10.3389/fphys.2012.00344
A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment, Gastroenterology, vol.144, issue.6, pp.1210-1219, 2013. ,
DOI : 10.1053/j.gastro.2012.11.037
An Intracellular Multi-Effector Complex Mediates Somatostatin Receptor 1 Activation of Phospho-Tyrosine Phosphatase ??, Molecular Endocrinology, vol.21, issue.1, pp.229-246, 2007. ,
DOI : 10.1210/me.2006-0081
Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1, Cellular and Molecular Life Sciences, vol.65, issue.19, pp.3110-3117, 2008. ,
DOI : 10.1007/s00018-008-8418-2
URL : https://hal.archives-ouvertes.fr/inserm-00420103
Identification, culture, and characterization of pancreatic stellate cells in rats and humans, Gastroenterology, vol.115, issue.2, pp.421-432, 1998. ,
DOI : 10.1016/S0016-5085(98)70209-4
Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells, Gastroenterology, vol.128, issue.4, pp.907-921, 2005. ,
DOI : 10.1053/j.gastro.2004.12.036
CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans, Science, vol.331, issue.6024, pp.1612-1616, 2011. ,
DOI : 10.1126/science.1198443
Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway, The EMBO Journal, vol.62, issue.17, pp.3943-3954, 2006. ,
DOI : 10.1128/MCB.22.12.4062-4072.2002
Current Scientific Rationale for the Use of Somatostatin Analogs and mTOR Inhibitors in Neuroendocrine Tumor Therapy, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.3, pp.727-737, 2012. ,
DOI : 10.1210/jc.2011-2088
Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer, Cancer Res, vol.56, pp.1823-1827, 1996. ,
Somatostatin analogs: does pharmacology impact antitumor efficacy?, Trends in Endocrinology & Metabolism, vol.25, issue.3, pp.115-127, 2014. ,
DOI : 10.1016/j.tem.2013.11.003
Phase I study of pasireotide (SOM 230) and everolimus (RAD001) in advanced neuroendocrine tumors, Endocrine Related Cancer, vol.19, issue.5, pp.615-623, 2012. ,
DOI : 10.1530/ERC-11-0382
The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilities, Molecular Oncology, vol.28, issue.2, pp.111-127, 2012. ,
DOI : 10.1016/j.gde.2012.01.004
StellaTUM: current consensus and discussion on pancreatic stellate cell research, Gut, vol.61, issue.2, pp.172-178, 2012. ,
DOI : 10.1136/gutjnl-2011-301220
The Impact of the Activated Stroma on Pancreatic Ductal Adenocarcinoma Biology and Therapy Resistance, Current Molecular Medicine, vol.12, issue.3, pp.288-303, 2012. ,
DOI : 10.2174/156652412799218921
Understanding the stroma of pancreatic cancer: co-evolution of the microenvironment with epithelial carcinogenesis, The Journal of Pathology, vol.35, issue.suppl???2, 2013. ,
DOI : 10.1002/path.4213
The Pancreas Cancer Microenvironment, Clinical Cancer Research, vol.18, issue.16, pp.4266-4276, 2012. ,
DOI : 10.1158/1078-0432.CCR-11-3114
Low-Dose Octreotide Treatment Is Not Effective in Patients with Advanced Pancreatic Cancer, Pancreas, vol.8, issue.5, pp.540-545, 1993. ,
DOI : 10.1097/00006676-199309000-00002
Retinoic Acid???Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt?????-Catenin Signaling to Slow Tumor Progression, Gastroenterology, vol.141, issue.4, pp.1486-1497, 2011. ,
DOI : 10.1053/j.gastro.2011.06.047
Tumour???stroma interactions in pancreatic ductal adenocarcinoma: Rationale and current evidence for new therapeutic strategies, Cancer Treatment Reviews, vol.40, issue.1, pp.118-128, 2014. ,
DOI : 10.1016/j.ctrv.2013.04.004
Hyperglycemia Associated With Pasireotide: Results From a Mechanistic Study in Healthy Volunteers, The Journal of Clinical Endocrinology & Metabolism, vol.98, issue.8, pp.3446-3453, 2013. ,
DOI : 10.1210/jc.2013-1771
Translational Therapeutic Opportunities in Ductal Adenocarcinoma of the Pancreas, Clinical Cancer Research, vol.18, issue.16, pp.4249-4256, 2012. ,
DOI : 10.1158/1078-0432.CCR-12-1327
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse, Cancer Cell, vol.4, issue.6, pp.437-450, 2003. ,
DOI : 10.1016/S1535-6108(03)00309-X
Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression, Cancer Research, vol.68, issue.3, pp.918-926, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-5714
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer, Gut, vol.62, issue.1, pp.112-120, 2013. ,
DOI : 10.1136/gutjnl-2012-302529
Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies, BMC Cancer, vol.68, issue.1, p.368, 2010. ,
DOI : 10.1158/0008-5472.CAN-07-6720
Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells, Cancer Research, vol.73, issue.7, pp.2345-2356, 2013. ,
DOI : 10.1158/0008-5472.CAN-12-3180
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer, Proceedings of the National Academy of Sciences, vol.106, issue.42, pp.17769-17774, 2009. ,
DOI : 10.1073/pnas.0908674106
URL : https://hal.archives-ouvertes.fr/inserm-00504705
Changes in Translational Control after Pro-Apoptotic Stress, International Journal of Molecular Sciences, vol.14, issue.1, pp.177-190, 2012. ,
DOI : 10.3390/ijms14010177
Dual roles of hemidesmosomal proteins in the pancreatic epithelium: the phosphoinositide 3-kinase decides, Oncogene, vol.56, issue.15, pp.1934-1944, 2014. ,
DOI : 10.1242/jcs.085480
Interleukin-6 in inflammatory and malignant diseases of the pancreas, Seminars in Immunology, vol.26, issue.1, pp.80-87, 2014. ,
DOI : 10.1016/j.smim.2014.01.002
Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner, Cancer Research, vol.73, issue.10, pp.3007-3018, 2013. ,
DOI : 10.1158/0008-5472.CAN-12-4601
Anti-oncogenic potential of the eIF4E-binding proteins, Oncogene, vol.336, issue.6, pp.671-677, 2013. ,
DOI : 10.1038/nrclinonc.2011.16
Pancreatic tumours escape from translational control through 4E-BP1 loss, Oncogene, vol.136, issue.11, pp.1363-1374, 2014. ,
DOI : 10.1371/journal.pone.0000242
Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling, Cell Reports, vol.9, issue.2, pp.484-494, 2014. ,
DOI : 10.1016/j.celrep.2014.09.010
Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase (PI3-kinase) pathway, Biochemical Pharmacology, vol.67, issue.6, pp.1215-1225, 2004. ,
DOI : 10.1016/j.bcp.2003.11.013
Environment-mediated drug resistance: a major contributor to minimal residual disease, Nature Reviews Cancer, vol.112, issue.9, pp.665-674, 2009. ,
DOI : 10.1038/nrc2714
Serum levels of IL-6 and IL-1beta can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer, 2013. ,
A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)-p85 to Filamin A Negatively Controls the PI3K Pathway, Molecular and Cellular Biology, vol.32, issue.5, pp.1004-1016, 2012. ,
DOI : 10.1128/MCB.06252-11
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer, Science, vol.324, issue.5933, pp.1457-1461, 2009. ,
DOI : 10.1126/science.1171362
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival, Cancer Cell, vol.25, issue.6, pp.719-734, 2014. ,
DOI : 10.1016/j.ccr.2014.04.005
What We Have Learned About Pancreatic Cancer From Mouse Models, Gastroenterology, vol.142, issue.5, pp.1079-1092, 2012. ,
DOI : 10.1053/j.gastro.2012.03.002
Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma, Cancer Cell, vol.21, issue.3, pp.418-429, 2012. ,
DOI : 10.1016/j.ccr.2012.01.007
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma, Cancer Cell, vol.25, issue.6, pp.735-747, 2014. ,
DOI : 10.1016/j.ccr.2014.04.021
Pasireotide (SOM230): Development, mechanism of action and potential applications, Molecular and Cellular Endocrinology, vol.286, issue.1-2, pp.69-74, 2008. ,
DOI : 10.1016/j.mce.2007.09.006
SUnSET, a nonradioactive method to monitor protein synthesis, Nature Methods, vol.178, issue.4, pp.275-277, 2009. ,
DOI : 10.1016/j.neuron.2005.01.015
URL : https://hal.archives-ouvertes.fr/hal-00408410
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy, Cell, vol.159, issue.1, pp.80-93, 2014. ,
DOI : 10.1016/j.cell.2014.08.007
Targeting miR-21 for the Therapy of Pancreatic Cancer, Molecular Therapy, vol.21, issue.5, pp.986-994, 2013. ,
DOI : 10.1038/mt.2013.35
Assessing therapeutic The Authors EMBO Molecular Medicine Anti-stromal-targeted therapy Camille Duluc et al responses in Kras mutant cancers using genetically engineered mouse models, EMBO Molecular Medicine Nat Biotechnol, vol.7, issue.28, pp.585-593, 2010. ,
-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial, Journal of Clinical Oncology, vol.29, issue.34, pp.4548-4554, 2011. ,
DOI : 10.1200/JCO.2011.36.5742
URL : https://hal.archives-ouvertes.fr/hal-00261277
Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells, Cancer Research, vol.68, issue.7, pp.2085-2093, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-2477
Oral mTOR Inhibitor Everolimus in Patients With Gemcitabine-Refractory Metastatic Pancreatic Cancer, Journal of Clinical Oncology, vol.27, issue.2, pp.193-198, 2009. ,
DOI : 10.1200/JCO.2008.18.9514
Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy, Nanoscale, vol.281, issue.22, pp.7185-7193, 2012. ,
DOI : 10.1039/c2nr31853a