M. N. Alekshun and S. B. Levy, Molecular Mechanisms of Antibacterial Multidrug Resistance, Cell, vol.128, issue.6, 2007.
DOI : 10.1016/j.cell.2007.03.004

F. Allerberger, T. Koeuth, C. Lass-florl, M. P. Dierich, C. Putensen et al., Epidemiology of infections due to multiresistantEnterobacter aerogenes in a University Hospital, European Journal of Clinical Microbiology & Infectious Diseases, vol.117, issue.Supplement 2, pp.517-521, 1007.
DOI : 10.1007/BF01691323

M. Anastay, E. Lagier, V. Blanc, and H. Chardon, ??pid??miologie des b??talactamases ?? spectre ??tendu (BLSE) chez les ent??robact??ries dans un h??pital du sud de la France, 1999???2007, Pathologie Biologie, vol.61, issue.2, pp.38-43, 1997.
DOI : 10.1016/j.patbio.2012.03.001

C. Arpin, C. Coze, A. M. Rogues, J. P. Gachie, C. Bebear et al., Epidemiological study of an outbreak due to multidrug-resistant Enterobacter aerogenes in a medical intensive care unit, J. Clin. Microbiol, vol.34, pp.2163-2169, 1996.

C. Arpin, R. Labia, V. Dubois, P. Noury, M. Souquet et al., TEM-80, a Novel Inhibitor-Resistant ??-Lactamase in a Clinical Isolate of Enterobacter cloacae, Antimicrobial Agents and Chemotherapy, vol.46, issue.5, pp.1183-1189, 2002.
DOI : 10.1128/AAC.46.5.1183-1189.2002

X. Bertrand, D. Hocquet, K. Boisson, E. Siebor, P. Plésiat et al., Molecular epidemiology of Enterobacteriaceae producing extended-spectrum ??-lactamase in a French university-affiliated hospital, International Journal of Antimicrobial Agents, vol.22, issue.2, pp.128-133, 2003.
DOI : 10.1016/S0924-8579(03)00098-0

M. Biendo, B. Canarelli, D. Thomas, F. Rousseau, F. Hamdad et al., Successive Emergence of Extended-Spectrum ??-Lactamase-Producing and Carbapenemase-Producing Enterobacter aerogenes Isolates in a University Hospital, Journal of Clinical Microbiology, vol.46, issue.3, pp.1037-1044, 1128.
DOI : 10.1128/JCM.00197-07

C. Bornet, A. Davin-regli, C. Bosi, J. M. Pagès, and C. Bollet, Imipenem resistance of Enterobacter aerogenes mediated by outer membrane permeability, J. Clin. Microbiol, vol.38, pp.1048-1052, 2000.

C. Bornet, N. Saint, L. Fetnaci, M. Dupont, A. Davin-régli et al., Omp35, a New Enterobacter aerogenes Porin Involved in Selective Susceptibility to Cephalosporins, Antimicrobial Agents and Chemotherapy, vol.48, issue.6, pp.2153-2158, 2004.
DOI : 10.1128/AAC.48.6.2153-2158.2004

C. Bosi, A. Davin-regli, C. Bornet, M. Malléa, J. M. Pagès et al., Most Enterobacter aerogenes strains in France belong to a prevalent clone, J. Clin. Microbiol, vol.37, pp.2165-2169, 1999.

H. W. Boucher, G. H. Talbot, J. S. Bradley, J. E. Edwards, D. Gilbert et al., Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America, Clinical Infectious Diseases, vol.48, issue.1, pp.1-12, 2009.
DOI : 10.1086/595011

A. Carbonne, I. Arnaud, S. Maugat, N. Marty, C. Dumartin et al., National multidrug-resistant bacteria (MDRB) surveillance in France through the RAISIN network: a 9 year experience, Journal of Antimicrobial Chemotherapy, vol.68, issue.4, pp.954-959, 2013.
DOI : 10.1093/jac/dks464

URL : https://hal.archives-ouvertes.fr/hal-00802748

R. N. Charrel, J. M. Pagès, P. De-micco, and M. Malléa, Prevalence of outer membrane porin alteration in ?-lactam-antibiotic-resistant Enterobacter aerogenes, Antimicrob. Agents Chemother, vol.40, pp.2854-2858, 1996.

J. Chevalier, M. Malléa, and J. M. Pagès, Comparative aspects of the diffusion of norfloxacin, cefepime and spermine through the F porin channel of Enterobacter cloacae, Biochemical Journal, vol.348, issue.1, pp.223-227, 2000.
DOI : 10.1042/bj3480223

J. Chevalier, C. Mulfinger, E. Garnotel, P. Nicolas, A. Davin-régli et al., Identification and evolution of drug efflux pump in clinical Enterobacter aerogenes strains, PLoS ONE, vol.3, 1995.

J. Chevalier, J. M. Pagès, and M. Malléa, In Vivo Modification of Porin Activity Conferring Antibiotic Resistance to Enterobacter aerogenes, Biochemical and Biophysical Research Communications, vol.266, issue.1, pp.248-251, 1999.
DOI : 10.1006/bbrc.1999.1795

R. Chollet, C. Bollet, J. Chevalier, M. Malléa, J. M. Pagès et al., mar Operon Involved in Multidrug Resistance of Enterobacter aerogenes, Antimicrobial Agents and Chemotherapy, vol.46, issue.4, pp.1093-1097, 2002.
DOI : 10.1128/AAC.46.4.1093-1097.2002

R. Chollet, J. Chevalier, C. Bollet, J. M. Pagès, and A. Davin-regli, RamA Is an Alternate Activator of the Multidrug Resistance Cascade in Enterobacter aerogenes, Antimicrobial Agents and Chemotherapy, vol.48, issue.7, pp.2518-2523, 2004.
DOI : 10.1128/AAC.48.7.2518-2523.2004

J. E. Corkill, J. J. Anson, H. , and C. A. , High prevalence of the plasmid-mediated quinolone resistance determinant qnrA in multidrug-resistant Enterobacteriaceae from blood cultures in Liverpool, UK, Journal of Antimicrobial Chemotherapy, vol.56, issue.6, pp.1115-1117, 2005.
DOI : 10.1093/jac/dki388

W. Dai, S. Sun, P. Yang, S. Huang, X. Zhang et al., Characterization of carbapenemases, extended spectrum ??-lactamases and molecular epidemiology of carbapenem-non-susceptible Enterobacter cloacae in a Chinese hospital in Chongqing, Infection, Genetics and Evolution, vol.14, pp.1-7, 2013.
DOI : 10.1016/j.meegid.2012.10.010

A. Davin-regli, J. M. Bolla, C. E. James, J. P. Lavigne, J. Chevalier et al., Membrane Permeability and Regulation of Drug “Influx and Efflux” in Enterobacterial Pathogens, Current Drug Targets, vol.9, issue.9, pp.750-759, 2008.
DOI : 10.2174/138945008785747824

A. Davin-regli, D. Monnet, P. Saux, C. Bosi, R. N. Charrel et al., Molecular epidemiology of Enterobacter aerogenes acquisition: oneyear prospective study in two intensive care units, J. Clin. Microbiol, vol.34, pp.1474-1480, 1996.

A. Davin-regli and J. M. Pagès, Cross-resistance between biocides and antimicrobials: an emerging question, Revue Scientifique et Technique de l'OIE, vol.31, issue.1, pp.89-104, 2012.
DOI : 10.20506/rst.31.1.2099

E. Dé, A. Baslé, M. Jaquinod, N. Saint, M. Malléa et al., A new mechanism of antibiotic resistance in Enterobacteriaceae induced by a structural modification of the major porin, Molecular Microbiology, vol.44, issue.1, pp.189-198, 2001.
DOI : 10.1046/j.1365-2958.2001.02501.x

D. Champs, C. Sauvant, M. P. Chanal, C. Sirot, D. Gazuy et al., Prospective survey of colonization and infection caused by expanded spectrum-beta-lactamase-producing members of the family Enterobacteriaceae in an intensive care unit, J. Antimicrob. Chemother, vol.27, pp.2887-2890, 1989.

Y. De-gheldre, N. Maes, F. Rost, R. De-ryck, P. Clevenbergh et al., Molecular epidemiology of an outbreak of multidrug-resistant Enterobacter aerogenes infections and in vivo emergence of imipenem resistance, J. Clin. Microbiol, vol.35, pp.152-160, 1997.

S. M. Diene, V. Merhej, M. Henry, A. Filali, V. Roux et al., The Rhizome of the Multidrug-Resistant Enterobacter aerogenes Genome Reveals How New "Killer Bugs" Are Created because of a Sympatric Lifestyle, Molecular Biology and Evolution, vol.30, issue.2, pp.369-383, 2009.
DOI : 10.1093/molbev/mss236

D. Du, Z. Wang, N. R. James, J. E. Voss, E. Klimont et al., Structure of the AcrAB???TolC multidrug efflux pump, Nature, vol.308, issue.7501, pp.512-515, 1038.
DOI : 10.1038/nature13205

G. Dugleux, L. Coutour, X. Hecquard, C. Oblin, and I. , Septicemia Caused by Contaminated Parenteral Nutrition Pouches: The Refrigerator as an Unusual Cause, Journal of Parenteral and Enteral Nutrition, vol.60, issue.4, pp.474-475, 1177.
DOI : 10.1177/0148607191015004474

P. Dumarche, C. De-champs, D. Sirot, C. Chanal, R. Bonnet et al., TEM Derivative-Producing Enterobacter aerogenes Strains: Dissemination of a Prevalent Clone, Antimicrobial Agents and Chemotherapy, vol.46, issue.4, pp.1128-1131, 2002.
DOI : 10.1128/AAC.46.4.1128-1131.2002

M. Dupont, C. E. James, J. Chevalier, and J. M. Pagès, An Early Response to Environmental Stress Involves Regulation of OmpX and OmpF, Two Enterobacterial Outer Membrane Pore-Forming Proteins, Antimicrobial Agents and Chemotherapy, vol.51, issue.9, pp.3190-3198, 1128.
DOI : 10.1128/AAC.01481-06

J. J. Farmer, . Iii, B. R. Davis, F. W. Hickman-brenner, A. Mcworther et al., Biochemical identification of new species and biogroups of Enterobacteriaceae isolated from clinical specimens, J. Clin. Microbiol, vol.21, pp.46-76, 1985.

F. Fata, S. Chittivelu, S. Tessler, and Y. Kupper, Gas Gangrene of the Arm Due to Enterobacter cloacae in a Neutropenic Patient, Southern Medical Journal, vol.89, issue.11, pp.1095-1096, 1996.
DOI : 10.1097/00007611-199611000-00014

V. Fernandez-baca, F. Ballesteros, J. A. Hervas, P. Villalon, A. et al., Molecular epidemiological typing of Enterobacter cloacae isolates from a neonatal intensive care unit: three-year prospective study, Journal of Hospital Infection, vol.49, issue.3, pp.173-182, 2001.
DOI : 10.1053/jhin.2001.1053

F. Fernandez-cuenca, J. M. Rodriguez-martinez, J. M. Martinez-martinez, and J. M. Pascual, In vivo selection of Enterobacter aerogenes with reduced susceptibility to cefepime and carbapenems associated with decreased expression of a 40kDa outer membrane protein and hyperproduction of AmpC ??-lactamase, International Journal of Antimicrobial Agents, vol.27, issue.6, pp.549-552, 2006.
DOI : 10.1016/j.ijantimicag.2006.01.005

J. Freney, M. O. Husson, F. Gavini, S. Madier, A. Martra et al., Susceptibilities to antibiotics and antiseptics of new species of the family Enterobacteriaceae., Antimicrobial Agents and Chemotherapy, vol.32, issue.6, pp.873-876, 1988.
DOI : 10.1128/AAC.32.6.873

I. Galani, M. Souli, Z. Chryssouli, K. Orlandou, H. M. Giamarellou et al., Characterization of a new integron containing blaVIM-1 and aac(6')-IIc in an Enterobacter cloacae clinical isolate from Greece, Journal of Antimicrobial Chemotherapy, vol.55, issue.5, pp.634-638, 1128.
DOI : 10.1093/jac/dki073

S. Gayet, R. Chollet, G. Molle, J. M. Pagès, C. et al., Modification of Outer Membrane Protein Profile and Evidence Suggesting an Active Drug Pump in Enterobacter aerogenes Clinical Strains, Antimicrobial Agents and Chemotherapy, vol.47, issue.5, pp.1555-1559, 2003.
DOI : 10.1128/AAC.47.5.1555-1559.2003

P. R. Georghiou, R. J. Hamill, C. E. Wright, J. Versalovic, T. T. Koeuth et al., Molecular Epidemiology of Infections Due to Enterobacter aerogenes: Identification of Hospital Outbreak-Associated Strains by Molecular Techniques, Clinical Infectious Diseases, vol.20, issue.1, pp.84-94, 1995.
DOI : 10.1093/clinids/20.1.84

F. Grattard, B. Pozzetto, L. Tabard, M. Petit, A. Ros et al., Characterization of Nosocomial Strains of Enterobacter aerogenes by Arbitrarily Primed-PCR Analysis and Ribotyping, Infection Control and Hospital Epidemiology, vol.16, issue.4, pp.224-230, 1995.
DOI : 10.2307/30140982

E. Hajjar, A. Bessonov, A. Molitor, A. Kumar, K. R. Mahendran et al., Toward Screening for Antibiotics with Enhanced Permeation Properties through Bacterial Porins, Biochemistry, vol.49, issue.32, pp.6928-6935, 1021.
DOI : 10.1021/bi100845x

E. Hajjar, K. R. Mahendran, A. Kumar, A. Bessonov, M. Petrescu et al., Bridging Timescales and Length Scales: From Macroscopic Flux to the Molecular Mechanism of Antibiotic Diffusion through Porins, Biophysical Journal, vol.98, issue.4, pp.569-575, 2010.
DOI : 10.1016/j.bpj.2009.10.045

S. Hammami, I. Boutiba-ben-boubaker, M. Saidani, E. Lakhal, B. Hassen et al., Isolated from a Tunisian Hospital, Microbial Drug Resistance, vol.18, issue.1, pp.59-65, 2012.
DOI : 10.1089/mdr.2011.0074

A. Hamprecht, L. Poirel, S. Gottig, H. Seifert, M. Kaase et al., Detection of the carbapenemase GIM-1 in Enterobacter cloacae in Germany, Journal of Antimicrobial Chemotherapy, vol.68, issue.3, pp.558-561, 2011.
DOI : 10.1093/jac/dks447

. Emmdr, a new member of the MATE family of multidrug transporters, extrudes quinolones from Enterobacter cloacae, Arch. Microbiol, vol.193, pp.759-765

S. Huang, W. Dai, S. Sun, X. Zhang, and L. Zhang, Prevalence of Plasmid-Mediated Quinolone Resistance and Aminoglycoside Resistance Determinants among Carbapeneme Non-Susceptible Enterobacter cloacae, PLoS ONE, vol.7, issue.10, 2012.
DOI : 10.1371/journal.pone.0047636.t004

R. Izdebski, A. Baraniak, M. Herda, J. Fiett, M. J. Bonten et al., MLST reveals potentially high-risk international clones of Enterobacter cloacae, Journal of Antimicrobial Chemotherapy, vol.70, issue.1, pp.48-56, 2014.
DOI : 10.1093/jac/dku359

S. Jalaluddin, J. M. Devaster, R. Scheen, M. Gerard, and J. P. Butzler, Molecular epidemiological study of nosocomial Enterobacter aerogenes isolates in a Belgian hospital, J. Clin. Microbiol, vol.36, pp.1846-1852, 1998.

C. E. James, K. R. Mahendran, A. Molitor, J. M. Bolla, A. N. Bessonov et al., How beta-lactam antibiotics enter bacteria: a dialogue with the porins, PLoS ONE, vol.4, 2009.

V. Jarlier, I. Fr-jaskulski, M. R. Medeiros, B. C. Borges, J. V. Zalewsky et al., Surveillance of Multidrug Resistant Bacteria in French Healthcare Facilities BMR-Raisin Network Données 2012 Saint-Maurice: Institut de Veille Sanitaire Available at: http://www.invs.sante Assessment of extended-spectrum ?-lactamase, KPC carbapenemase and porin resistance mechanisms in clinical samples of Klebsiella pneumoniae and Enterobacter spp, Int. J. Antimicrob. Agents, vol.42, pp.76-79, 2013.

H. Kanamori, Y. Hisakasu, H. Yoichi, H. Ayako, A. Kazuaki et al., Molecular Characteristics of Extended-Spectrum Beta-Lactamases and qnr Determinants in Enterobacter Species from Japan, PLoS ONE, vol.51, issue.6, 2012.
DOI : 10.1371/journal.pone.0037967.t002

A. Khajuria, A. K. Praharaj, M. Kumar, G. , and N. , Carbapenem resistance among Enterobacter species in a tertiary care hospital in central India, Chemother. Res. Pract, p.972646, 2014.

S. Y. Kim, Y. J. Park, J. K. Yu, Y. S. Kim, and K. Han, Prevalence and characteristics of aac(6???)-Ib-cr in AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens: a multicenter study from Korea, Diagnostic Microbiology and Infectious Disease, vol.63, issue.3, pp.314-318, 2009.
DOI : 10.1016/j.diagmicrobio.2008.11.016

J. M. Langley, M. Hanakowski, and J. C. Leblanc, Unique epidemiology of nosocomial urinary tract infection in children, American Journal of Infection Control, vol.29, issue.2, pp.94-98, 2001.
DOI : 10.1067/mic.2001.111537

J. P. Lavigne, A. Sotto, M. H. Nicolas-chanoine, N. Bouziges, G. Bourg et al., Membrane permeability, a pivotal function involved in antibiotic resistance and virulence in Enterobacter aerogenes clinical isolates, Clinical Microbiology and Infection, vol.18, issue.6, pp.539-545, 2012.
DOI : 10.1111/j.1469-0691.2011.03607.x

J. P. Lavigne, A. Sotto, M. H. Nicolas-chanoine, N. Bouziges, J. M. Pagès et al., An adaptive response of Enterobacter aerogenes to imipenem: regulation of porin balance in clinical isolates, International Journal of Antimicrobial Agents, vol.41, issue.2, pp.130-136, 2013.
DOI : 10.1016/j.ijantimicag.2012.10.010

A. J. Lawler, V. Ricci, S. J. Busby, and L. J. Piddock, Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA, Journal of Antimicrobial Chemotherapy, vol.68, issue.7, pp.1551-1557, 2013.
DOI : 10.1093/jac/dkt069

E. H. Lee, E. Collatz, J. Trias, and L. Gutmann, Diffusion of ??-lactam antibiotics into proteoliposomes reconstituted with outer membranes of isogenic imipenem-susceptible and -resistant strains of Enterobacter cloacae, Journal of General Microbiology, vol.138, issue.11, pp.2347-2351, 1992.
DOI : 10.1099/00221287-138-11-2347

H. K. Lee, Y. J. Park, J. Y. Kim, E. Chang, S. G. Cho et al., Prevalence of decreased susceptibility to carbapenems among Serratia marcescens, Enterobacter cloacae, and Citrobacter freundii and investigation of carbapenemases, Diagnostic Microbiology and Infectious Disease, vol.52, issue.4, pp.331-336, 2005.
DOI : 10.1016/j.diagmicrobio.2005.04.012

S. H. Lee, S. H. Jeong, and P. S. , Characterization of blaCMY-10 a novel, plasmid-encoded AmpC-type beta-lactamase gene in a clinical isolate of Enterobacter aerogenes, Journal of Applied Microbiology, vol.43, issue.4, pp.744-752, 2002.
DOI : 10.1128/AAC.44.6.1438-1442.2000

M. Malléa, J. Chevalier, C. E. Bornet, A. Eyraud, A. Davin-regli et al., Porin alteration and active efflux: two in vivo drug resistance strategies used by Enterobacter aerogenes, Microbiology, vol.144, issue.11, pp.3003-3009, 1998.
DOI : 10.1099/00221287-144-11-3003

M. Malléa, V. Simonet, E. H. Lee, R. Gervier, E. Collatz et al., Biological and immunological comparisons of and porins, FEMS Microbiology Letters, vol.129, issue.2-3, pp.273-279, 1995.
DOI : 10.1016/0378-1097(95)00171-Z

A. Martins, G. Spengler, M. Martins, L. Rodrigues, M. Viveiros et al., Physiological characterisation of the efflux pump system of antibiotic-susceptible and multidrug-resistant Enterobacter aerogenes, International Journal of Antimicrobial Agents, vol.36, issue.4, pp.313-318, 2010.
DOI : 10.1016/j.ijantimicag.2010.06.036

M. Masi and J. M. Pagès, Structure, Function and Regulation of Outer Membrane Proteins Involved in Drug Transport in Enterobactericeae: the OmpF/C ??? TolC Case, The Open Microbiology Journal, vol.7, issue.1, pp.22-33, 2013.
DOI : 10.2174/1874285801307010022

M. Masi, J. M. Pagès, and E. Pradel, Production of the cryptic EefABC efflux pump in Enterobacter aerogenes chloramphenicol-resistant mutants, Journal of Antimicrobial Chemotherapy, vol.57, issue.6, pp.1223-1226, 2006.
DOI : 10.1093/jac/dkl139

M. Masi, J. M. Pagès, C. Villard, and E. Pradel, The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes, Journal of Bacteriology, vol.187, issue.11, 2005.
DOI : 10.1128/JB.187.11.3894-3897.2005

M. L. Mezzatesta, F. Gona, S. , and S. , complex: clinical impact and emerging antibiotic resistance, Future Microbiology, vol.7, issue.7, pp.887-902, 2012.
DOI : 10.2217/fmb.12.61

E. Miro, C. Alonso, F. Navarro, B. Mirelis, and G. Prats, Resistencia al imipenem en Enterobacter aerogenes, Enferm. Infecc. Microbiol. Clin, vol.13, pp.278-282, 1995.

E. Miró, F. Grünbaum, L. Gómez, A. Rivera, B. Mirelis et al., Clinical Strains and Characterization of the Plasmids Implicated in Their Diffusion, Microbial Drug Resistance, vol.19, issue.2, pp.94-99, 2013.
DOI : 10.1089/mdr.2012.0125

C. Nauciel, A. Philippon, E. Ronco, J. Pilliot, M. Guenounou et al., Septicémies à Enterobacter cloacae et E. aerogenes: émergence de variants résistants, Presse Med, vol.14, pp.673-676, 1985.

C. Neuwirth, E. Siebor, J. Lopez, A. Pechinot, and A. Kazmierczak, Outbreak of TEM-24-producing Enterobacter aerogenes in an intensive care unit and dissemination of the extended-spectrum ?-lactamase to other members of the family Enterobacteriacae, J. Clin. Microbiol, vol.34, pp.76-79, 1996.

H. Nikaido, J. M. Pagès, S. Mariotte, T. Naas, R. Labia et al., Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria, FEMS Microbiology Reviews, vol.36, issue.2, pp.340-363, 1993.
DOI : 10.1111/j.1574-6976.2011.00290.x

J. M. Pagès, C. E. James, and M. Winterhalter, The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria, Nature Reviews Microbiology, vol.390, issue.12, pp.893-903, 1038.
DOI : 10.1016/S0969-2126(99)80055-0

Y. Park, J. Yu, S. Kim, K. Lee, and Y. Arakawa, Accumulation of plasmid-mediated fluoroquinolone resistance genes, qepA and qnrS1, 2009.

A. Pérez, D. Canle, C. Latasa, M. Poza, A. Beceiro et al., Cloning, Nucleotide Sequencing, and Analysis of the AcrAB-TolC Efflux Pump of Enterobacter cloacae and Determination of Its Involvement in Antibiotic Resistance in a Clinical Isolate, Antimicrobial Agents and Chemotherapy, vol.51, issue.9, pp.3247-3253, 1128.
DOI : 10.1128/AAC.00072-07

A. Pérez, M. Poza, J. Aranda, C. Latasa, F. J. Medrano et al., Effect of Transcriptional Activators SoxS, RobA, and RamA on Expression of Multidrug Efflux Pump AcrAB-TolC in Enterobacter cloacae, Antimicrobial Agents and Chemotherapy, vol.56, issue.12, pp.6256-6266, 1128.
DOI : 10.1128/AAC.01085-12

N. Pestourie, F. Garnier, O. Barraud, A. Bedu, M. C. Ploy et al., Outbreak of AmpC ??-lactamase-hyper-producing Enterobacter cloacae in a neonatal intensive care unit in a French teaching hospital, American Journal of Infection Control, vol.42, issue.4, pp.456-458, 2014.
DOI : 10.1016/j.ajic.2013.11.005

L. J. Piddock, Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria, Clinical Microbiology Reviews, vol.19, issue.2, pp.382-402, 2006.
DOI : 10.1128/CMR.19.2.382-402.2006

J. D. Pitout, C. C. Sanders, S. , and W. E. Jr, Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli, Am. J. Med, vol.10397, pp.51-59, 1997.

J. D. Pitout, K. S. Thomson, N. D. Hanson, A. F. Ehrhardt, P. Coudron et al., Plasmid-mediated resistance to expanded-spectrum cephalosporins among Enterobacter aerogenes strains, Antimicrob. Agents Chemother, vol.42, pp.596-600, 1998.

L. Poirel, J. D. Pitout, and P. Nordmann, Carbapenemases: molecular diversity and clinical consequences, Future Microbiology, vol.2, issue.5, 2007.
DOI : 10.2217/17460913.2.5.501

A. Potron, L. Poirel, E. Rondinaud, and P. Nordmann, Intercontinental spread of OXA-48 ?-lactamase-producing Enterobacteriaceae over a 11- year period, Euro. Surveill, 2001.

E. Pradel and J. M. Pagès, The AcrAB-TolC Efflux Pump Contributes to Multidrug Resistance in the Nosocomial Pathogen Enterobacter aerogenes, Antimicrobial Agents and Chemotherapy, vol.46, issue.8, 2002.
DOI : 10.1128/AAC.46.8.2640-2643.2002

K. E. Preston, C. C. Radomski, and R. A. Venezia, Nucleotide Sequence of the Chromosomal ampC Gene of Enterobacter aerogenes, Antimicrobial Agents and Chemotherapy, vol.44, issue.11, pp.3158-3162, 2000.
DOI : 10.1128/AAC.44.11.3158-3162.2000

M. P. Quiroga, P. Andres, A. Petroni, S. Bistué, A. J. Guerriero et al., Complex Class 1 Integrons with Diverse Variable Regions, Including aac(6')-Ib-cr, and a Novel Allele, qnrB10, Associated with ISCR1 in Clinical Enterobacterial Isolates from Argentina, Antimicrobial Agents and Chemotherapy, vol.51, issue.12, pp.4466-4470, 1128.
DOI : 10.1128/AAC.00726-07

A. Raimondi, A. Traverso, and H. Nikaido, Imipenem-and meropenemresistant mutants of Enterobacter cloacae and Proteus rettgeri lack porins, Antimicrob. Agents Chemother, vol.35, 1991.

L. B. Rice, Progress and Challenges in Implementing the Research on ESKAPE Pathogens, Infection Control & Hospital Epidemiology, vol.10, issue.S1, pp.7-10, 2010.
DOI : 10.1111/j.1365-2958.1995.tb02268.x

J. Robert, A. Pantel, A. Mérens, J. P. Lavigne, M. H. Nicolas-chanoine et al., Incidence rates of carbapenemase-producing Enterobacteriaceae clinical isolates in France: a prospective nationwide study in 2011-12, Journal of Antimicrobial Chemotherapy, vol.69, issue.10, pp.2706-2712, 2014.
DOI : 10.1093/jac/dku208

URL : https://hal.archives-ouvertes.fr/hal-01061610

W. E. Sanders, S. , and C. C. , Enterobacter spp.: pathogens poised to flourish at the turn of the century, Clin. Microbiol. Rev, vol.10, pp.220-241, 1997.

E. Song, K. Park, E. Jang, E. Lee, Y. Chong et al., Comparison of the clinical and microbiologic characteristics of patients with Enterobacter cloacae and Enterobacter aerogenes bacteremia: a prospective observation study, Diagnostic Microbiology and Infectious Disease, vol.66, issue.4, pp.436-440, 2010.
DOI : 10.1016/j.diagmicrobio.2009.11.007

J. Stoorvogel, M. J. Van-bussel, J. Tommassen, and J. A. Van-de-klundert, Molecular characterization of an Enterobacter cloacae outer membrane protein (OmpX)., Journal of Bacteriology, vol.173, issue.1, pp.156-160, 1991.
DOI : 10.1128/jb.173.1.156-160.1991

D. Szabo, M. A. Melan, A. M. Hujer, R. A. Bonomo, K. M. Hujer et al., Molecular Analysis of the Simultaneous Production of Two SHV-Type Extended-Spectrum Beta-Lactamases in a Clinical Isolate of Enterobacter cloacae by Using Single-Nucleotide Polymorphism Genotyping, Antimicrobial Agents and Chemotherapy, vol.49, issue.11, pp.4716-4720, 2005.
DOI : 10.1128/AAC.49.11.4716-4720.2005

A. Thiolas, C. Bollet, L. Scola, B. Raoult, D. Pagès et al., Successive Emergence of Enterobacter aerogenes Strains Resistant to Imipenem and Colistin in a Patient, Antimicrobial Agents and Chemotherapy, vol.49, issue.4, pp.1354-1358, 2005.
DOI : 10.1128/AAC.49.4.1354-1358.2005

E. Torres, L. López-cerero, D. Toro, M. D. Pascual, and A. , First detection and characterization of an OXA-48-producing Enterobacter aerogenes isolate, Enfermedades Infecciosas y Microbiolog??a Cl??nica, vol.32, issue.7, pp.469-470, 2014.
DOI : 10.1016/j.eimc.2013.10.008

Q. T. Tran, M. Dupont, J. P. Lavigne, J. Chevalier, J. M. Pagès et al., Occurrence of Efflux Mechanism and Cephalosporinase Variant in a Population of Enterobacter aerogenes and Klebsiella pneumoniae Isolates Producing Extended-Spectrum ??-Lactamases, Antimicrobial Agents and Chemotherapy, vol.53, issue.4, pp.1652-1656, 1128.
DOI : 10.1128/AAC.00822-08

E. Valade, A. Davin-regli, J. Bolla, and J. Pagès, Bacterial Membrane, a Key for Controlling Drug Influx and Efflux, Antibiotics: Targets, Mechanisms and Resistance, pp.217-240, 2013.
DOI : 10.1002/9783527659685.ch9

M. Veleba, S. De-majumdar, M. Hornsey, N. Woodford, and T. Schneiders, Genetic characterization of tigecycline resistance in clinical isolates of Enterobacter cloacae and Enterobacter aerogenes, Journal of Antimicrobial Chemotherapy, vol.68, issue.5, pp.1011-1018, 2013.
DOI : 10.1093/jac/dks530

S. Vidal, J. Bredin, J. Pagès, and J. Barbe, ??-Lactam Screening by Specific Residues of the OmpF Eyelet, Journal of Medicinal Chemistry, vol.48, issue.5, pp.1395-400, 2005.
DOI : 10.1021/jm049652e

S. A. Wang, J. I. Tokars, P. J. Bianchine, L. A. Carson, M. J. Arduino et al., Enterobacter cloacae Bloodstream Infections Traced to Contaminated Human Albumin, Clinical Infectious Diseases, vol.30, issue.1, pp.35-40, 1086.
DOI : 10.1086/313585

H. Yigit, G. J. Anderson, J. W. Biddle, C. D. Steward, J. K. Rasheed et al., Carbapenem Resistance in a Clinical Isolate of Enterobacter aerogenes Is Associated with Decreased Expression of OmpF and OmpC Porin Analogs, Antimicrobial Agents and Chemotherapy, vol.46, issue.12, pp.3817-3822, 2002.
DOI : 10.1128/AAC.46.12.3817-3822.2002

A. Zaher and N. Cimolai, ERIC-PCR typing profiles of Enterobacter cloacae are stable after development of advanced cephalosporin resistance, International Journal of Antimicrobial Agents, vol.9, issue.3, pp.165-167, 1997.
DOI : 10.1016/S0924-8579(97)00046-0