P. Cossart and P. Sansonetti, Bacterial Invasion: The Paradigms of Enteroinvasive Pathogens, Science, vol.304, issue.5668, pp.242-248, 2004.
DOI : 10.1126/science.1090124

R. Carabeo, Bacterial subversion of host actin dynamics at the plasma membrane, Cellular Microbiology, vol.5, issue.10, pp.1460-1469, 2011.
DOI : 10.1111/j.1462-5822.2011.01651.x

S. Yoshida and C. Sasakawa, Exploiting host microtubule dynamics: a new aspect of bacterial invasion, Trends in Microbiology, vol.11, issue.3, pp.139-143, 2003.
DOI : 10.1016/S0966-842X(03)00023-4

M. Donnenberg, A. Donohue-rolfe, and G. Keusch, A comparison of HEp-2 cell invasion by enteropathogenic and enteroinvasive Escherichia coli, FEMS Microbiol Lett, vol.57, pp.83-86, 1990.

J. St-geme, I. Falkow, and S. , Haemophilus influenzae adheres to and enters cultured human epithelial cells, Infect Immun, vol.58, pp.4036-4044, 1990.

T. Oelschlaeger, P. Guerry, and D. Kopecko, Unusual microtubule-dependent endocytosis mechanisms triggered by Campylobacter jejuni and Citrobacter freundii., Proceedings of the National Academy of Sciences, vol.90, issue.14, pp.6884-6888, 1993.
DOI : 10.1073/pnas.90.14.6884

H. Grassmé, R. Ireland, and J. Van-putten, Gonococcal opacity protein promotes bacterial entry-associated rearrangements of the epithelial cell actin cytoskeleton, Infect Immun, vol.64, pp.1621-1630, 1996.

J. Taylor, L. Hogue, J. Lipuma, M. Walter, S. Brody et al., Entry of Burkholderia organisms into respiratory epithelium: CFTR, microfilament and microtubule dependence, Journal of Cystic Fibrosis, vol.9, issue.1, pp.36-43, 2010.
DOI : 10.1016/j.jcf.2009.10.002

E. Kipnis, T. Sawa, and J. Wiener-kronish, Targeting mechanisms of??Pseudomonas??aeruginosa pathogenesis, M??decine et Maladies Infectieuses, vol.36, issue.2, pp.78-91, 2006.
DOI : 10.1016/j.medmal.2005.10.007

E. Chi, T. Mehl, D. Nunn, and L. S. , Interaction of Pseudomonas aeruginosa with A549 pneumocyte cells, Infect Immun, vol.59, pp.822-828, 1991.

J. Engel and Y. Eran, Subversion of Mucosal Barrier Polarity by Pseudomonas Aeruginosa, Frontiers in Microbiology, vol.2, p.114, 2011.
DOI : 10.3389/fmicb.2011.00114

K. Darling, A. Dewar, and T. Evans, Role of the cystic fibrosis transmembrane conductance regulator in internalization of Pseudomonas aeruginosa by polarized respiratory epithelial cells, Cellular Microbiology, vol.126, issue.6, pp.521-533, 2004.
DOI : 10.1111/j.1462-5822.2004.00380.x

S. Fleiszig, D. Evans, N. Do, V. Vallas, S. Shin et al., Epithelial cell polarity affects susceptibility to Pseudomonas aeruginosa invasion and cytotoxicity, Infect Immun, vol.65, pp.2861-2867, 1997.

M. Wolfgang, B. Kulasekara, X. Liang, D. Boyd, K. Wu et al., Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa, Proceedings of the National Academy of Sciences, vol.100, issue.14, pp.8484-8489, 2003.
DOI : 10.1073/pnas.0832438100

D. Wareham and M. Curtis, A genotypic and phenotypic comparison of type III secretion profiles of Pseudomonas aeruginosa cystic fibrosis and bacteremia isolates, International Journal of Medical Microbiology, vol.297, issue.4, pp.227-234, 2007.
DOI : 10.1016/j.ijmm.2007.02.004

S. Fleiszig and D. Evans, The pathogenesis of bacterial keratitis: studies with Pseudomonas aeruginosa, Clinical and Experimental Optometry, vol.34, issue.5, pp.271-278, 2002.
DOI : 10.1111/j.1444-0938.2002.tb03082.x

B. Kazmierczak, T. Jou, K. Mostov, and J. Engel, Rho GTPase activity modulates Pseudomonas aeruginosa internalization by epithelial cells, Cellular Microbiology, vol.112, issue.2, pp.85-98, 2001.
DOI : 10.1084/jem.185.2.281

S. Fleiszig, T. Zaidi, and G. Pier, Pseudomonas aeruginosa invasion of and multiplication within corneal epithelial cells in vitro, Infect Immun, vol.63, pp.4072-4077, 1995.

A. Kierbel, A. Gassama-diagne, K. Mostov, and J. Engel, The Phosphoinositol-3-Kinase-Protein Kinase B/Akt Pathway Is Critical for Pseudomonas aeruginosa Strain PAK Internalization, Molecular Biology of the Cell, vol.16, issue.5, pp.2577-2585, 2005.
DOI : 10.1091/mbc.E04-08-0717

T. Sana, A. Hachani, I. Bucior, C. Soscia, S. Garvis et al., The Second Type VI Secretion System of Pseudomonas aeruginosa Strain PAO1 Is Regulated by Quorum Sensing and Fur and Modulates Internalization in Epithelial Cells, Journal of Biological Chemistry, vol.287, issue.32, pp.27095-27105, 2012.
DOI : 10.1074/jbc.M112.376368

URL : https://hal.archives-ouvertes.fr/hal-01458258

F. Jiang, N. Waterfield, Y. J. Yang, G. , and J. Q. , A Pseudomonas aeruginosa Type VI Secretion Phospholipase D Effector Targets Both Prokaryotic and Eukaryotic Cells, Cell Host & Microbe, vol.15, issue.5, pp.600-610, 2014.
DOI : 10.1016/j.chom.2014.04.010

N. Kapitein and A. Mogk, Deadly syringes: type VI secretion system activities in pathogenicity and interbacterial competition, Current Opinion in Microbiology, vol.16, issue.1, pp.52-58, 2013.
DOI : 10.1016/j.mib.2012.11.009

B. Ho, T. Dong, and J. Mekalanos, A View to a Kill: The Bacterial Type VI Secretion System, Cell Host & Microbe, vol.15, issue.1, pp.9-21, 2014.
DOI : 10.1016/j.chom.2013.11.008

A. Russell, S. Peterson, and J. Mougous, Type VI secretion system effectors: poisons with a purpose, Nature Reviews Microbiology, vol.8, issue.2, pp.137-148, 2014.
DOI : 10.1038/nrmicro3185

A. Zoued, Y. Brunet, E. Durand, M. Aschtgen, L. Logger et al., Architecture and assembly of the Type VI secretion system, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1843, issue.8, pp.1664-1673, 2014.
DOI : 10.1016/j.bbamcr.2014.03.018

URL : https://hal.archives-ouvertes.fr/hal-01458220

J. Silverman, Y. Brunet, E. Cascales, and J. Mougous, Structure and Regulation of the Type VI Secretion System, Annual Review of Microbiology, vol.66, issue.1, pp.453-472, 2012.
DOI : 10.1146/annurev-micro-121809-151619

URL : https://hal.archives-ouvertes.fr/hal-01458240

S. Pukatzki, A. Ma, D. Sturtevant, B. Krastins, D. Sarracino et al., Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system, Proceedings of the National Academy of Sciences, vol.103, issue.5, pp.1528-1533, 2006.
DOI : 10.1073/pnas.0510322103

T. Brooks, D. Unterweger, V. Bachmann, B. Kostiuk, and S. Pukatzki, Lytic Activity of the Vibrio cholerae Type VI Secretion Toxin VgrG-3 Is Inhibited by the Antitoxin TsaB, Journal of Biological Chemistry, vol.288, issue.11, pp.7618-7625, 2013.
DOI : 10.1074/jbc.M112.436725

T. Dong, B. Ho, D. Yoder-himes, and J. Mekalanos, Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae, Proceedings of the National Academy of Sciences, vol.110, issue.7, pp.2623-2628, 2013.
DOI : 10.1073/pnas.1222783110

A. Russell, M. Leroux, K. Hathazi, D. Agnello, T. Ishikawa et al., Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors, Nature, vol.277, issue.7446, pp.508-512, 2013.
DOI : 10.1038/nature12074

S. Bleves, T. Sana, and R. Voulhoux, The target cell genus does not matter, Trends in Microbiology, vol.22, issue.6, pp.304-306, 2014.
DOI : 10.1016/j.tim.2014.04.011

URL : https://hal.archives-ouvertes.fr/hal-01458219

S. Pukatzki, A. Ma, A. Revel, D. Sturtevant, and J. Mekalanos, Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin, Proceedings of the National Academy of Sciences, vol.104, issue.39, pp.15508-15513, 2007.
DOI : 10.1073/pnas.0706532104

G. Suarez, J. Sierra, T. Erova, J. Sha, A. Horneman et al., A Type VI Secretion System Effector Protein, VgrG1, from Aeromonas hydrophila That Induces Host Cell Toxicity by ADP Ribosylation of Actin, Journal of Bacteriology, vol.192, issue.1, pp.155-16801260, 2010.
DOI : 10.1128/JB.01260-09

E. Durand, C. Cambillau, E. Cascales, and L. Journet, VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors, Trends in Microbiology, vol.22, issue.9, pp.498-507, 2014.
DOI : 10.1016/j.tim.2014.06.004

URL : https://hal.archives-ouvertes.fr/hal-01458195

S. Miyata, M. Kitaoka, T. Brooks, S. Mcauley, and S. Pukatzki, Vibrio cholerae Requires the Type VI Secretion System Virulence Factor VasX To Kill Dictyostelium discoideum, Infection and Immunity, vol.79, issue.7, pp.2941-2949, 2011.
DOI : 10.1128/IAI.01266-10

M. Barret, F. Egan, E. Fargier, J. Morrissey, O. Gara et al., Genomic analysis of the type VI secretion systems in Pseudomonas spp.: novel clusters and putative effectors uncovered, Microbiology, vol.157, issue.6, pp.1726-1739, 2011.
DOI : 10.1099/mic.0.048645-0

J. Mougous, M. Cuff, S. Raunser, A. Shen, M. Zhou et al., A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus, Science, vol.312, issue.5779, pp.1526-1530, 2006.
DOI : 10.1126/science.1128393

A. Hachani, N. Lossi, A. Hamilton, C. Jones, S. Bleves et al., Type VI Secretion System in Pseudomonas aeruginosa: SECRETION AND MULTIMERIZATION OF VgrG PROTEINS, Journal of Biological Chemistry, vol.286, issue.14, pp.12317-12327, 2011.
DOI : 10.1074/jbc.M110.193045

URL : https://hal.archives-ouvertes.fr/hal-01458269

T. Sana, C. Soscia, C. Tonglet, S. Garvis, and S. Bleves, Divergent control of two type VI secretion systems by RpoN in Pseudomonas aerugin o s a . P L o S O n e 8, 2013.

A. Müller, A. Fauster, C. Holze, K. Lindsten, S. Goodbourn et al., Viral immune modulators perturb the human molecular network by common and unique strategies, Nature, vol.487, pp.486-490, 2012.

M. Gstaiger and R. Aebersold, Applying mass spectrometry-based proteomics to genetics, genomics and network biology, Nature Reviews Genetics, vol.6, issue.9, pp.617-627, 2009.
DOI : 10.1038/nrg2633

J. Kollman, A. Merdes, L. Mourey, and D. Agard, Microtubule nucleation by ??-tubulin complexes, Nature Reviews Molecular Cell Biology, vol.119, issue.11, pp.709-721, 2011.
DOI : 10.1038/nrm3209

L. Tilney and K. Porter, STUDIES ON THE MICROTUBULES IN HELIOZOA: II. The Effect of Low Temperature on These Structures in the Formation and Maintenance of the Axopodia, The Journal of Cell Biology, vol.34, issue.1, pp.327-343, 1967.
DOI : 10.1083/jcb.34.1.327

O. Behnke and A. Forer, Evidence for four classes of microtubules in individual cells, J Cell Sci, vol.2, pp.169-192, 1967.

R. Mittal, M. Grati, R. Gerring, P. Blackwelder, D. Yan et al., In Vitro Interaction of Pseudomonas aeruginosa with Human Middle Ear Epithelial Cells, PLoS ONE, vol.15, issue.3, 2014.
DOI : 10.1371/journal.pone.0091885.s005

D. Evans, D. Frank, V. Finck-barbançon, C. Wu, and S. Fleiszig, Pseudomonas aeruginosa invasion and cytotoxicity are independent events, both of which involve protein tyrosine kinase activity, Infect Immun, vol.66, pp.1453-1459, 1998.

F. Bartolini and G. Gundersen, Generation of noncentrosomal microtubule arrays, Journal of Cell Science, vol.119, issue.20, pp.4155-4163, 2006.
DOI : 10.1242/jcs.03227

R. Bacallao, C. Antony, C. Dotti, E. Karsenti, E. Stelzer et al., The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium, The Journal of Cell Biology, vol.109, issue.6, pp.2817-2832, 1989.
DOI : 10.1083/jcb.109.6.2817

L. Macurek, E. Dráberová, V. Richterová, V. Sulimenko, T. Sulimenko et al., Regulation of microtubule nucleation from membranes by complexes of membrane-bound ??-tubulin with Fyn kinase and phosphoinositide 3-kinase, Biochemical Journal, vol.416, issue.3, pp.421-430, 2008.
DOI : 10.1042/BJ20080909

URL : https://hal.archives-ouvertes.fr/hal-00479022

A. Khandani, E. Eng, J. Jongstra-bilen, A. Schreiber, D. Douda et al., Microtubules regulate PI-3K activity and recruitment to the phagocytic cup during Fc?? receptor-mediated phagocytosis in nonelicited macrophages, Journal of Leukocyte Biology, vol.82, issue.2, pp.417-428, 2007.
DOI : 10.1189/jlb.0706469

A. Aiastui, M. Pucciarelli, and F. García-del-portillo, Salmonella enterica Serovar Typhimurium Invades Fibroblasts by Multiple Routes Differing from the Entry into Epithelial Cells, Infection and Immunity, vol.78, issue.6, pp.2700-2713, 2010.
DOI : 10.1128/IAI.01389-09

E. Rudashevskaya, R. Sacco, K. Kratochwill, M. Huber, M. Gstaiger et al., A method to resolve the composition of heterogeneous affinity-purified protein complexes assembled around a common protein by chemical cross-linking, gel electrophoresis and mass spectrometry, Nature Protocols, vol.601, issue.1, pp.75-97, 2013.
DOI : 10.1038/nmeth785

F. Fava, B. Raynaud-messina, J. Leung-tack, L. Mazzolini, M. Li et al., Human 76p, The Journal of Cell Biology, vol.110, issue.4, pp.857-868, 1999.
DOI : 10.1038/378578a0