Journal articles
Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma
Abstract : Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory HCs that occur in response to ototoxic and traumatic stressor events. The roles of inflammatory processes, oxidative stress, mitochondrial damage, cell death receptors, members of the mitogen-activated protein kinase (MAPK) signal pathway and pro- and anti-cell death members of the Bcl-2 family are explored. The molecular interaction of these signal pathways that initiates the loss of auditory HCs following acoustic trauma is covered and possible therapeutic interventions that may protect these sensory HCs from loss via apoptotic or non-apoptotic cell death are explored.
Keywords :
trauma
cochlea
auditory hair cells
apoptosis
inflammation
necrosis
otoprotection
repair
NECROSIS-FACTOR-ALPHA
INDUCED HEARING-LOSS
MITOCHONDRIAL PERMEABILITY TRANSITION
NF-KAPPA-B
SPIRAL LIGAMENT FIBROCYTES
CISPLATIN-INDUCED OTOTOXICITY
COCHLEAR IMPLANTATION TRAUMA
GENTAMICIN-INDUCED COCHLEAR
STRESS-INDUCED APOPTOSIS
FAS LIGAND EXPRESSION
Cited literature [178 references]
https://hal-amu.archives-ouvertes.fr/hal-01216717
Contributor : Administrateur Hal Amu <>
Submitted on : Friday, October 16, 2015 - 5:41:30 PM
Last modification on : Thursday, April 16, 2020 - 1:12:03 PM
Long-term archiving on: : Monday, January 18, 2016 - 6:06:13 AM
Contributor : Administrateur Hal Amu <>
Submitted on : Friday, October 16, 2015 - 5:41:30 PM
Last modification on : Thursday, April 16, 2020 - 1:12:03 PM
Long-term archiving on: : Monday, January 18, 2016 - 6:06:13 AM
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