J. D. Amaral, J. M. Xavier, C. J. Steer, and C. M. Rodrigues, The role of p53 in apoptosis, Discov. Med, vol.9, pp.145-152, 2010.

S. Aminpour, S. P. Tinling, and H. A. Brodie, Role of Tumor Necrosis Factor-?? in Sensorineural Hearing Loss after Bacterial Meningitis, Otology & Neurotology, vol.26, issue.4, pp.602-609, 2005.
DOI : 10.1097/01.mao.0000178121.28365.0d

S. A. Andrabi, T. M. Dawson, D. , and V. L. , Mitochondrial and Nuclear Cross Talk in Cell Death, Annals of the New York Academy of Sciences, vol.27, issue.Pt 2, pp.233-241, 2008.
DOI : 10.1196/annals.1427.014

C. P. Baines, R. A. Kaiser, N. H. Purcell, N. S. Blair, H. Osinska et al., Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death, Nature, vol.65, issue.7033, pp.658-662, 1038.
DOI : 10.1038/sj.gt.3301048

E. Bas, C. Gupta, and T. R. Van-de-water, A Novel Organ of Corti Explant Model for the Study of Cochlear Implantation Trauma, The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, vol.60, issue.11, pp.1944-1956, 2012.
DOI : 10.1002/ar.22585

E. Bas, F. Martinez-soriano, J. M. Láinez, M. , and J. , An experimental comparative study of dexamethasone, melatonin and tacrolimus in noise-induced hearing loss, Acta Oto-Laryngologica, vol.1754, issue.4, pp.385-389, 1080.
DOI : 10.1080/00016480802566279

E. Bas, T. R. Van-de-water, C. Gupta, J. Dinh, L. Vu et al., Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses, British Journal of Pharmacology, vol.163, issue.6, pp.1888-1904, 2012.
DOI : 10.1111/j.1476-5381.2012.01890.x

K. B. Beckman and B. N. Ames, Oxidative Decay of DNA, Journal of Biological Chemistry, vol.272, issue.32, pp.19633-19636, 1997.
DOI : 10.1074/jbc.272.32.19633

J. S. Beckman and W. H. Koppenol, Nitric oxide, superoxide and peroxynitrite: the good, the bad and ugly, Am. J. Physiol, vol.271, pp.1424-1437, 1996.

J. L. Bodmer, K. Burns, P. Schneider, K. Hofmann, V. Steiner et al., TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95), Immunity, vol.6, issue.1, 1997.
DOI : 10.1016/S1074-7613(00)80244-7

S. B. Bratton, G. Walker, S. M. Srinivasula, X. M. Sun, M. Butterworth et al., Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes, The EMBO Journal, vol.20, issue.5, pp.998-1009, 2001.
DOI : 10.1093/emboj/20.5.998

C. Brenner and S. Grimm, The permeability transition pore complex in cancer cell death, Oncogene, vol.123, issue.34, pp.4744-4756, 2006.
DOI : 10.1016/j.canlet.2005.09.001

D. Brough and N. J. Rothwell, Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death, Journal of Cell Science, vol.120, issue.5, pp.772-781, 2007.
DOI : 10.1242/jcs.03377

V. Budhram-mahadeo, P. J. Morris, M. D. Smith, C. A. Midgley, L. M. Boxer et al., p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor, Journal of Biological Chemistry, vol.274, issue.21, pp.15237-15244, 1999.
DOI : 10.1074/jbc.274.21.15237

B. Cai, S. H. Chang, E. B. Becker, A. Bonni, and Z. Xia, p38 MAP Kinase Mediates Apoptosis through Phosphorylation of BimEL at Ser-65, Journal of Biological Chemistry, vol.281, issue.35, pp.25215-25222, 2006.
DOI : 10.1074/jbc.M512627200

K. Cain, S. B. Bratton, C. Langlais, G. Walker, D. G. Brown et al., Apaf-1 Oligomerizes into Biologically Active 700-kDa and Inactive 1.4-MDa Apoptosome Complexes, Journal of Biological Chemistry, vol.275, issue.9, pp.6067-6070, 2000.
DOI : 10.1074/jbc.275.9.6067

M. Capano and M. Crompton, Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases, Biochemical Journal, vol.395, issue.1, pp.57-64, 2006.
DOI : 10.1042/BJ20051654

J. Chai, C. Du, J. W. Wu, S. Kyin, X. Wang et al., Structural and biochemical basis of apoptotic activation by Smac/DIABLO, Nature, vol.406, pp.855-862, 1038.

J. Chai, E. Shiozaki, S. M. Srinivasula, Q. Wu, P. Datta et al., Structural Basis of Caspase-7 Inhibition by XIAP, Cell, vol.104, issue.5, pp.769-780, 2001.
DOI : 10.1016/S0092-8674(01)00272-0

J. M. Chandler, G. M. Cohen, and M. Macfarlane, Different Subcellular Distribution of Caspase-3 and Caspase-7 following Fas-induced Apoptosis in Mouse Liver, Journal of Biological Chemistry, vol.273, issue.18, pp.10815-10818, 1998.
DOI : 10.1074/jbc.273.18.10815

Z. Chen, T. B. Gibson, F. Robinson, L. Silvestro, G. Pearson et al., MAP Kinases, Chemical Reviews, vol.101, issue.8, pp.2449-2476, 1995.
DOI : 10.1021/cr000241p

Y. H. Choung, A. Taura, K. Pak, S. J. Choi, M. Masuda et al., Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of corti treated with gentamicin, Neuroscience, vol.161, issue.1, pp.214-226, 2009.
DOI : 10.1016/j.neuroscience.2009.02.085

A. B. Coffin, E. W. Rubel, R. , and D. W. , Bax, Bcl2, and p53 Differentially Regulate Neomycin- and Gentamicin-Induced Hair Cell Death in the Zebrafish Lateral Line, Journal of the Association for Research in Otolaryngology, vol.120, issue.1, pp.645-659, 2013.
DOI : 10.1007/s10162-013-0404-1

J. N. Coleman, C. Littlesunday, R. Jackson, M. , and T. , AM-111 protects against permanent hearing loss from impulse noise trauma, Hearing Research, vol.226, issue.1-2, pp.70-78, 2007.
DOI : 10.1016/j.heares.2006.05.006

D. A. Cotanche, A. K. Hennig, A. E. Riedl, and E. P. Messana, Hair cell regeneration in the chick cochlea --were we stand after 10 years of work, Psychophysical and Physiological Advances in Hearing: Proceedings of the 11 th International Symposium on Hearing: Whurr), pp.109-115, 1997.

E. Daugas, S. A. Susin, N. Zamzami, K. F. Ferri, T. Irinopoulou et al., Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis, FASEB J, vol.14, pp.729-739, 2000.
URL : https://hal.archives-ouvertes.fr/hal-00315088

Y. Deng, X. Ren, L. Yang, Y. Lin, and X. Wu, A JNK-Dependent Pathway Is Required for TNF??-Induced Apoptosis, Cell, vol.115, issue.1, pp.61-70, 2003.
DOI : 10.1016/S0092-8674(03)00757-8

S. L. Deshmane, S. Kremlev, S. Amini, and B. E. Sawaya, Monocyte Chemoattractant Protein-1 (MCP-1): An Overview, Journal of Interferon & Cytokine Research, vol.29, issue.6, pp.313-3260027, 2008.
DOI : 10.1089/jir.2008.0027

Q. L. Deveraux, E. Leo, H. R. Stennicke, K. Welsh, G. S. Salvesen et al., Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases, The EMBO Journal, vol.18, issue.19, pp.5242-5251, 1999.
DOI : 10.1093/emboj/18.19.5242

D. N. Dhanasekaran and E. P. Reddy, JNK signaling in apoptosis, Oncogene, vol.19, issue.48, pp.6245-6251, 2008.
DOI : 10.1016/S0960-9822(02)00547-X

D. Ding, H. Jiang, and R. J. Salvi, Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid, Hearing Research, vol.259, issue.1-2, pp.16-23, 2010.
DOI : 10.1016/j.heares.2009.08.008

C. T. Dinh, E. Bas, S. S. Chan, J. N. Dinh, L. Vu et al., Dexamethasone treatment of tumor necrosis factor-alpha challenged organ of Corti explants activates nuclear factor kappa B signaling that induces changes in gene expression that favor hair cell survival, Neuroscience, vol.188, pp.157-167, 2011.
DOI : 10.1016/j.neuroscience.2011.04.061

C. Dinh, E. Bas, J. Dinh, L. Vu, C. Gupta et al., Short Interfering RNA against Bax Attenuates TNF??-Induced Ototoxicity in Rat Organ of Corti Explants, Otolaryngology-Head and Neck Surgery, vol.139, issue.5, pp.834-840, 1177.
DOI : 10.1006/meth.2001.1262

C. Dinh, K. Hoang, S. Haake, S. Chen, S. Angeli et al., Biopolymer-Released Dexamethasone Prevents Tumor Necrosis Factor ??-Induced Loss of Auditory Hair Cells In Vitro, Otology & Neurotology, vol.29, issue.7, pp.1012-1019, 2008.
DOI : 10.1097/MAO.0b013e3181859a1f

S. J. Dixon, K. M. Lemberg, M. R. Lamprecht, R. Skouta, E. M. Zaitsev et al., Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death, Cell, vol.149, issue.5, pp.1060-1072, 2012.
DOI : 10.1016/j.cell.2012.03.042

N. Donovan, E. B. Becker, Y. Konishi, and A. Bonni, JNK Phosphorylation and Activation of BAD Couples the Stress-activated Signaling Pathway to the Cell Death Machinery, Journal of Biological Chemistry, vol.277, issue.43, pp.40944-40949, 2002.
DOI : 10.1074/jbc.M206113200

R. Dworakowski, N. Anilkumar, M. Zhang, and A. M. Shah, Redox signalling involving NADPH oxidase-derived reactive oxygen species, Biochemical Society Transactions, vol.34, issue.5, pp.960-964, 2006.
DOI : 10.1042/BST0340960

S. T. Eichhorst, M. Müller, M. Li-weber, H. Schulze-bergkamen, P. Angel et al., A Novel AP-1 Element in the CD95 Ligand Promoter Is Required for Induction of Apoptosis in Hepatocellular Carcinoma Cells upon Treatment with Anticancer Drugs, Molecular and Cellular Biology, vol.20, issue.20, pp.7826-78377826, 2000.
DOI : 10.1128/MCB.20.20.7826-7837.2000

M. Enari, H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu et al., A caspase-activated DNase that degrades DNA during apoptosis and its inhibitos ICAD, Nature, vol.391, pp.43-50, 1038.

A. A. Eshraghi, J. He, C. H. Mou, M. Polak, A. Zine et al., D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma, Otol. Neurotol, vol.27, pp.504-511, 2006.

A. A. Eshraghi, G. Hoosien, S. Ramsay, C. T. Dinh, E. Bas et al., Inhibition of the JNK Signal Cascade Conserves Hearing Against Electrode Insertion Trauma-Induced Loss, Cochlear Implants International, vol.23, issue.sup1, pp.104-109, 1179.
DOI : 10.2174/1568007043337166

P. Evans, B. M. Halliwell, M. E. Goodwin, M. J. Birrer, and T. C. Chambers, Free Radicals and Hearing: Cause, Consequence, and Criteria, Annals of the New York Academy of Sciences, vol.128, issue.Suppl., pp.19-40, 1999.
DOI : 10.1111/j.1749-6632.1999.tb08633.x

M. Faris, N. Kokot, K. Latinis, S. Kasibhatla, D. R. Green et al., The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression, J. Immunol, vol.160, pp.134-144, 1998.

T. Fernandes-alnemri, J. Wu, J. W. Yu, P. Datta, B. Miller et al., The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation, Cell Death and Differentiation, vol.78, issue.9, pp.1590-1604, 2007.
DOI : 10.1016/j.cell.2004.05.004

A. R. Fetoni, R. Piacentini, A. Fiorita, G. Paludetti, and D. Troiani, Water-solube Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise-induced hearing loss (NIHL), Brain Res, vol.125712, pp.108-116027, 2008.

I. S. Figari, N. A. Mori, M. A. Palladino, and . Jr, Regulation of neutrophil migration and superoxide production by recombinant tumor necrosis factors-alpha and -beta: comparison to recombinant interferongamma and interleukin-1 alpha, Blood, vol.70, pp.979-984, 1987.

S. L. Fink and B. T. Cookson, Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages, Cellular Microbiology, vol.165, issue.11, pp.1812-1825, 2006.
DOI : 10.1016/S0962-8924(01)02206-1

M. Fujioka, S. Kanzaki, H. J. Okano, M. Masuda, K. Ogawa et al., Proinflammatory cytokines expression in noise-induced damaged cochlea, Journal of Neuroscience Research, vol.137, issue.4, pp.575-583, 2006.
DOI : 10.1002/jnr.20764

L. Galluzzi, I. Vitale, J. M. Abrams, E. S. Alnemri, E. H. Baehreck et al., Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012, Cell Death and Differentiation, vol.94, issue.1, pp.107-120, 2012.
DOI : 10.1083/jcb.200712051

M. E. Guicciardi and G. J. Gores, Life and death by death receptors, The FASEB Journal, vol.23, issue.6, pp.1625-1637, 2009.
DOI : 10.1096/fj.08-111005

S. M. Haake, C. T. Dinh, S. Chen, A. A. Eshraghi, and T. R. Van-de-water, Dexamethasone protects auditory hair cells against TNF??-initiated apoptosis via activation of PI3K/Akt and NF??B signaling, Hearing Research, vol.255, issue.1-2, pp.22-32, 2009.
DOI : 10.1016/j.heares.2009.05.003

J. Hagenbuchner, A. Kuznetsov, M. Hermann, B. Hausott, P. Obexer et al., FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3, Journal of Cell Science, vol.125, issue.5, pp.1191-1203, 2012.
DOI : 10.1242/jcs.092098

W. Han, X. Shi, and A. L. Nuttall, AIF and endoG translocation in noise exposure induced hair cell death, Hearing Research, vol.211, issue.1-2, pp.85-95, 2006.
DOI : 10.1016/j.heares.2005.10.004

S. He, L. Wang, L. Miao, T. Wang, F. Du et al., Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-??, Cell, vol.137, issue.6, pp.1100-1111, 2009.
DOI : 10.1016/j.cell.2009.05.021

R. Hegde, S. M. Srinivasula, Z. Zhang, R. Wassell, R. Mukattash et al., Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction, Journal of Biological Chemistry, vol.277, issue.1, pp.432-438, 2002.
DOI : 10.1074/jbc.M109721200

K. Hirose and M. C. Liberman, Lateral Wall Histopathology and Endocochlear Potential in the Noise-Damaged Mouse Cochlea, JARO - Journal of the Association for Research in Otolaryngology, vol.4, issue.3, pp.339-352, 2003.
DOI : 10.1007/s10162-002-3036-4

K. Hirose, L. E. Westrum, D. E. Cunningham, and E. W. Rubel, Electron microscopy of degenerative changes in the chick basilar papilla after gentamicin exposure, The Journal of Comparative Neurology, vol.19, issue.2, pp.164-180, 2004.
DOI : 10.1002/cne.11046

S. C. Hsu, M. A. Gavrilin, M. H. Tsai, J. Han, and M. Z. Lai, p38 Mitogen-activated Protein Kinase Is Involved in Fas Ligand Expression, Journal of Biological Chemistry, vol.274, issue.36, pp.25769-25776, 1999.
DOI : 10.1074/jbc.274.36.25769

H. Hsu, J. Xiong, and D. V. Goeddel, The TNF receptor 1-associated protein TRADD signals cell death and NF-??B activation, Cell, vol.81, issue.4, pp.495-504, 1995.
DOI : 10.1016/0092-8674(95)90070-5

B. H. Hu, D. Henderson, and T. M. Nicotera, Extremely rapid induction of outer hair cell apoptosis in the chinchilla cochlea following exposure to impulse noise, Hearing Research, vol.211, issue.1-2, pp.16-25, 2006.
DOI : 10.1016/j.heares.2005.08.006

T. Huang, A. G. Cheng, H. Stupak, W. Liu, A. Kim et al., Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies, International Journal of Developmental Neuroscience, vol.18, issue.2-3, pp.259-270, 2000.
DOI : 10.1016/S0736-5748(99)00094-5

I. Ichimiya, K. Yoshida, T. Hirano, M. Suzuki, and G. Mogi, Significance of spiral ligament fibrocytes with cochlear inflammation, International Journal of Pediatric Otorhinolaryngology, vol.56, issue.1, pp.45-51, 2000.
DOI : 10.1016/S0165-5876(00)00408-0

I. Ichimiya, K. Yoshida, M. Suzuki, and G. Mogi, Expression of Adhesion Molecules by Cultured Spiral Ligament Fibrocytes Stimulated with Proinflammatory Cytokines, Annals of Otology, Rhinology & Laryngology, vol.72, issue.8, pp.722-728, 2003.
DOI : 10.1177/000348940311200813

E. B. Infante, G. A. Channer, F. F. Telischi, C. Gupta, J. T. Dinh et al., Mannitol Protects Hair Cells Against Tumor Necrosis Factor ?????Induced Loss, Otology & Neurotology, vol.33, issue.9, pp.1656-1663, 1993.
DOI : 10.1097/MAO.0b013e31826bedd9

S. Jamesdaniel, B. Hu, M. H. Kermany, H. Jiang, D. Ding et al., Noise induced changes in the expression of p38/MAPK signaling proteins in the sensory epithelium of the inner ear, Journal of Proteomics, vol.75, issue.2, pp.410-424, 2011.
DOI : 10.1016/j.jprot.2011.08.007

H. Jiang, S. H. Sha, A. Forge, and J. Schacht, Caspase-independent pathways of hair cell death induced by kanamycin in vivo, Cell Death and Differentiation, vol.95, issue.1, pp.20-30, 2006.
DOI : 10.1046/j.1471-4159.2002.00935.x

V. E. Kagan, V. A. Tyurin, J. Jiang, Y. Y. Tyurina, V. B. Ritov et al., Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors, Nature Chemical Biology, vol.464, issue.4, pp.223-232, 2005.
DOI : 10.1089/152308604322899288

K. Kandasamy, S. M. Srinivasula, E. S. Alnemri, C. B. Thompson, S. J. Korsmeyer et al., Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLo release, Cancer Res, vol.63, pp.1712-1721, 2003.

E. M. Keithley, X. Wang, and G. C. Barkdull, Tumor Necrosis Factor ?? Can Induce Recruitment of Inflammatory Cells to the Cochlea, Otology & Neurotology, vol.29, issue.6, pp.854-859, 2008.
DOI : 10.1097/MAO.0b013e31818256a9

O. Kepp, L. Galluzzi, L. Zitvogel, and G. Kroemer, Pyroptosis - a cell death modality of its kind?, European Journal of Immunology, vol.104, issue.3, pp.627-630, 0200.
DOI : 10.1002/eji.200940160

Y. Keshet and R. Seger, The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions, Methods Mol. Biol, vol.661, pp.3-38, 2008.
DOI : 10.1007/978-1-60761-795-2_1

R. Kohen and A. Nyska, Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification, Toxicologic Pathology, vol.59, issue.6, pp.620-650, 2002.
DOI : 10.1080/01926230290166724

S. J. Korsmeyer, M. C. Wei, M. Saito, S. Weiler, K. J. Oh et al., Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c, Cell Death and Differentiation, vol.7, issue.12, pp.1166-1173, 2000.
DOI : 10.1038/sj.cdd.4400783

M. Kovacsovics, F. Martinon, O. Micheau, J. L. Bodmer, K. Hofmann et al., Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation, Current Biology, vol.12, issue.10, pp.838-843, 2002.
DOI : 10.1016/S0960-9822(02)00842-4

G. Kroemer, L. Galluzzi, and C. Brenner, Mitochondrial Membrane Permeabilization in Cell Death, Physiological Reviews, vol.87, issue.1, pp.99-163, 2006.
DOI : 10.1152/physrev.00013.2006
URL : https://hal.archives-ouvertes.fr/hal-00172652

M. Kuhn, S. E. Heman-ackah, J. A. Shaikh, R. , and P. C. , Sudden Sensorineural Hearing Loss: A Review of Diagnosis, Treatment, and Prognosis, Trends in Amplification, vol.15, issue.3, pp.91-105, 1177.
DOI : 10.1177/1084713811408349

S. G. Kujawa and M. C. Liberman, Adding Insult to Injury: Cochlear Nerve Degeneration after "Temporary" Noise-Induced Hearing Loss, Journal of Neuroscience, vol.29, issue.45, pp.14077-14085, 2009.
DOI : 10.1523/JNEUROSCI.2845-09.2009

T. Kurioka, T. Matsunobu, K. Niwa, A. Tamura, Y. Satoh et al., Activated protein C rescues the cochlea from noise-induced hearing loss, Brain Research, vol.1583, pp.201-210, 2014.
DOI : 10.1016/j.brainres.2014.07.052

T. Kuwana, M. R. Mackey, G. Perkins, M. H. Ellisman, M. Latterich et al., Bid, Bax and lipids cooperat to form supramolecula ropenings in the outer mitochondrial membrane Mammalian mitogen-activated protein kinase signal transcution pathways activated by stress and inflammation, Cell Physiol. Rev, vol.111, issue.81, pp.331-342, 2001.

M. Lamkanfi, T. D. Kanneganti, P. Van-damme, T. Vanden-berghe, I. Vanoverberghe et al., Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes, Molecular & Cellular Proteomics, vol.7, issue.12, pp.2350-2363, 2008.
DOI : 10.1074/mcp.M800132-MCP200

K. Lei, D. , and R. J. , JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis, Proceedings of the National Academy of Sciences, vol.100, issue.5, pp.2432-2437, 2003.
DOI : 10.1073/pnas.0438011100

K. Lei, A. Nimnual, W. X. Zong, N. J. Kennedy, R. A. Flavell et al., The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH2-Terminal Kinase, Molecular and Cellular Biology, vol.22, issue.13, pp.4929-4942, 2002.
DOI : 10.1128/MCB.22.13.4929-4942.2002

L. Prell, C. G. Yamashita, D. Minami, S. B. Yamasoba, T. Miller et al., Mechanisms of noise-induced hearing loss indicate multiple methods of prevention, Hearing Research, vol.226, issue.1-2, pp.22-43, 2007.
DOI : 10.1016/j.heares.2006.10.006

L. Y. Li, X. Luo, W. , and X. , Endonuclease G is an apoptotic DNase when released from mitochondria, Nature, vol.412, issue.6842, pp.95-99, 1038.
DOI : 10.1038/35083620

W. Li, S. M. Srinivasula, J. Chai, P. Li, J. W. Wu et al., Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi, Nature Structural Biology, vol.9, issue.6, pp.436-441, 1038.
DOI : 10.1038/nsb795

H. Li, H. Zhu, C. J. Xu, and J. Yuan, Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis, Cell, vol.94, issue.4, pp.491-501, 1998.
DOI : 10.1016/S0092-8674(00)81590-1

F. R. Lin, J. K. Niparko, and L. Ferrucci, Hearing Loss Prevalence in the United States, Archives of Internal Medicine, vol.171, issue.20, pp.1851-1852, 2011.
DOI : 10.1001/archinternmed.2011.506

J. Liu and A. Lin, Role of JNK activation in apoptosis: A double-edged sword, Cell Research, vol.13, issue.1, pp.36-42, 2005.
DOI : 10.1074/jbc.M206113200

X. Liu, H. Zou, C. Slaughter, W. , X. Lorenzo et al., DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis Apoptosis inducing factor (AIF): a phylogenetically old caspase-independent effector of cell death, Cell Cell Death Differ, vol.89, issue.6, pp.175-184, 1997.

W. K. Low, M. G. Tan, A. W. Chua, L. Sun, W. et al., 12th Yahya Cohen memorial lecture: the cellular and molecular basis of radiation-induced sensorineural hearing loss, Ann. Acad. Med. Singapore, vol.38, pp.91-94, 2009.

X. Luo, I. Budihardjo, H. Zou, C. Slaughter, W. et al., Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors, Cell, vol.94, issue.4, pp.481-490, 1998.
DOI : 10.1016/S0092-8674(00)81589-5

M. Madesh, B. Antonsson, S. M. Srinivasula, E. S. Alnemri, G. Y. Hajnoczky et al., Rapid Kinetics of tBid-induced Cytochrome c and Smac/DIABLO Release and Mitochondrial Depolarization, Journal of Biological Chemistry, vol.277, issue.7, pp.5651-5659, 2002.
DOI : 10.1074/jbc.M108171200

K. Maeda, K. Yoshida, I. Ichimiya, and M. Suzuki, Dexamethasone inhibits tumor necrosis factor-??-induced cytokine secretion from spiral ligament fibrocytes, Hearing Research, vol.202, issue.1-2, pp.154-160, 2005.
DOI : 10.1016/j.heares.2004.08.022

M. Delavary, B. Van-der-veer, W. M. Van-egmond, M. Niessen, F. B. Beelen et al., Macrophages in skin injury and repair, Immunobiology, vol.216, issue.7, pp.753-762, 2011.
DOI : 10.1016/j.imbio.2011.01.001

D. A. Mangiardi, K. Mclaughlin-williamson, K. E. May, E. P. Messana, D. C. Mountain et al., Progression of hair cell ejection and molecular markers of apoptosis in the avian cochlea following gentamicin treatment, The Journal of Comparative Neurology, vol.163, issue.1, pp.1-8, 2004.
DOI : 10.1002/cne.20129

P. Marchetti, M. Castedo, S. A. Susin, N. Zamzami, T. Hirsch et al., Mitochondrial permeability transition is a central coordinating event of apoptosis, Journal of Experimental Medicine, vol.184, issue.3, pp.1155-1160, 1996.
DOI : 10.1084/jem.184.3.1155

T. Markou, A. A. Dowling, T. Kelly, and A. Lazou, Regulation of Bcl-2 phosphorylation in response to oxidative stress in cardiac myocytes, Free Radical Research, vol.24, issue.9, pp.809-816, 1080.
DOI : 10.1074/jbc.M800951200

K. D. Marshall and C. P. Baines, Necroptosis: is there a role for mitochondria?, Frontiers in Physiology, vol.109, 2014.
DOI : 10.1073/pnas.1200012109

I. Marzo, C. Brenner, and G. Kroemer, The central role of the mitochondrial megachannel in apoptosis: evidence obtained with intact cells, isolated mitochondria, and purified protein complexes, Biomedicine & Pharmacotherapy, vol.52, issue.6, pp.248-251, 1998.
DOI : 10.1016/S0753-3322(98)80009-7

J. I. Matsui, J. E. Gale, and M. E. Warchol, Critical signaling events during the aminoglycoside-induced death of sensory hair cellsin vitro, Journal of Neurobiology, vol.274, issue.2, pp.250-266, 2004.
DOI : 10.1002/neu.20054

S. Mccomb, H. H. Cheung, R. G. Korneluk, S. Wang, L. Krishnan et al., cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation, Cell Death and Differentiation, vol.147, issue.11, pp.1791-1801, 2012.
DOI : 10.1128/MCB.25.8.3348-3356.2005

D. Milhas, O. Cuvillier, N. Therville, P. Clavé, M. Thomsen et al., Caspase-10 Triggers Bid Cleavage and Caspase Cascade Activation in FasL-induced Apoptosis, Journal of Biological Chemistry, vol.280, issue.20, pp.19836-19842, 2005.
DOI : 10.1074/jbc.M414358200

N. Murai, M. Kirkegaard, L. Järlebark, M. Risling, A. Suneson et al., Activation of JNK in the Inner Ear following Impulse Noise Exposure, Journal of Neurotrauma, vol.25, issue.1, pp.72-770346, 2007.
DOI : 10.1089/neu.2007.0346

S. E. Mutsaers, J. E. Bishop, G. Mcgrouther, L. , and G. J. , Mechanisms of tissue repair: from wound healing to fibrosis, The International Journal of Biochemistry & Cell Biology, vol.29, issue.1, pp.5-17, 1997.
DOI : 10.1016/S1357-2725(96)00115-X

H. Nagai, T. Noguchi, K. Takeda, and H. Ichijo, Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways, BMB Reports, vol.40, issue.1, pp.1-6, 2007.
DOI : 10.5483/BMBRep.2007.40.1.001

S. Nagata, Fas Ligand-Induced Apoptosis, Annual Review of Genetics, vol.33, issue.1, pp.29-55, 1999.
DOI : 10.1146/annurev.genet.33.1.29

T. Nakagawa, S. Shimizu, T. Watanabe, O. Yamaguchi, K. Otsu et al., Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death, Nature, vol.12, issue.7033, pp.652-658, 1038.
DOI : 10.1084/jem.189.11.1699

M. Nakamagoe, K. Tabuchi, I. Uemaetomari, B. Nishimura, and A. Hara, Estradiol protects the cochlea against gentamicin ototoxicity through inhibition of the JNK pathway, Hearing Research, vol.261, issue.1-2, pp.67-74, 2010.
DOI : 10.1016/j.heares.2010.01.004

P. W. Ng, A. G. Porter, J. , and R. U. , Molecular Cloning and Characterization of Two Novel Pro-apoptotic Isoforms of Caspase-10, Journal of Biological Chemistry, vol.274, issue.15, pp.10301-10308, 1999.
DOI : 10.1074/jbc.274.15.10301

T. M. Nicotera, D. Ding, S. L. Mcfadden, D. Salvemini, and R. Salvi, Paraquat-Induced Hair Cell Damage and Protection with the Superoxide Dismutase Mimetic M40403, Audiology and Neuro-Otology, vol.9, issue.6, pp.353-362, 2004.
DOI : 10.1159/000081284

T. M. Nicotera, B. H. Hu, H. , and D. , The Caspase Pathway in Noise-Induced Apoptosis of the Chinchilla Cochlea, JARO - Journal of the Association for Research in Otolaryngology, vol.4, issue.4, pp.466-477, 2003.
DOI : 10.1007/s10162-002-3038-2

L. Nordang and M. Anniko, Nitro-L-arginine methyl ester: A potential protector against gentamicin ototoxicity, Acta Oto-Laryngologica, vol.257, issue.10, pp.1033-1038, 2005.
DOI : 10.1002/(SICI)1097-0029(19970201)36:3<201::AID-JEMT8>3.0.CO;2-R

K. K. Ohlemiller, S. L. Mcfadden, D. L. Ding, P. M. Lear, Y. S. Ho et al., Targeted Mutation of the Gene for Cellular Glutathione Peroxidase (Gpx1) Increases Noise-Induced Hearing Loss in Mice, Journal of the Association for Research in Otolaryngology, vol.1, issue.3, pp.243-254, 1159.
DOI : 10.1007/s101620010043

N. V. Oleinik, N. I. Krupenko, and S. A. Krupenko, Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway, Oncogene, vol.270, issue.51, pp.7222-7230, 2007.
DOI : 10.1038/sj.onc.1210526

K. Op-de-beeck, J. Schacht, V. Camp, and G. , Apoptosis in acquired and genetic hearing impairment: The programmed death of the hair cell, Hearing Research, vol.281, issue.1-2, pp.18-27, 2011.
DOI : 10.1016/j.heares.2011.07.002

S. Ottilie, J. L. Diaz, W. Horne, J. Chang, Y. Wang et al., Dimerization Properties of Human BAD: IDENTIFICATION OF A BH-3 DOMAIN AND ANALYSIS OF ITS BINDING TO MUTANT BCL-2 AND BCL-XL PROTEINS, Journal of Biological Chemistry, vol.272, issue.49, pp.30866-30872, 1997.
DOI : 10.1074/jbc.272.49.30866

T. W. Owens, A. J. Valentijn, J. P. Upton, J. Keeble, L. Zhang et al., Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK, Cell Death and Differentiation, vol.52, issue.11, pp.1551-1562102, 2009.
DOI : 10.1126/science.1076979

H. L. Pahl, Activators and target genes of Rel/NF-??B transcription factors, Oncogene, vol.18, issue.49, pp.6853-6866, 1999.
DOI : 10.1038/sj.onc.1203239

H. Y. Park, M. H. Lee, S. U. Kang, H. S. Hwang, K. Park et al., Nitric oxide mediates TNF-??-induced apoptosis in the auditory cell line, The Laryngoscope, vol.22, issue.10, pp.2256-2264, 2012.
DOI : 10.1002/lary.23444

S. Pathak, E. Goldofsky, E. X. Vivas, V. R. Bonagura, and A. Vambutas, IL-1?? Is Overexpressed and Aberrantly Regulated in Corticosteroid Nonresponders with Autoimmune Inner Ear Disease, The Journal of Immunology, vol.186, issue.3, pp.1870-1879, 2011.
DOI : 10.4049/jimmunol.1002275

U. Pirvola, L. Xingqun, J. Virkkala, M. Saarma, C. Murakata et al., Rescue of hearing, auditory hair cells and neurons by CEP1347/KT7515, an inhibitor of cJun Nterminal kinase activation, J. Neurosci, vol.20, pp.43-50, 2000.

A. Porras, S. Zuluaga, E. Black, A. Valladares, A. M. Alvarez et al., p38?? Mitogen-activated Protein Kinase Sensitizes Cells to Apoptosis Induced by Different Stimuli, Molecular Biology of the Cell, vol.15, issue.2, pp.922-933, 2004.
DOI : 10.1091/mbc.E03-08-0592

P. Proost, A. Wuyts, and J. Van-damme, The role of chemokines in inflammation, International Journal of Clinical and Laboratory Research, vol.156, issue.128, pp.211-223, 1996.
DOI : 10.1007/BF02602952

H. Puthalakath, D. C. Huang, L. A. O-'reilly, S. M. King, and A. Strasser, The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex, Molecular Cell, vol.3, issue.3, pp.287-296, 1999.
DOI : 10.1016/S1097-2765(00)80456-6

J. H. Pyun, S. U. Kang, H. S. Hwang, Y. T. Oh, S. H. Kang et al., Epicatechin inhibits radiation-induced auditory cell death by suppression of reactive oxygen species generation, Neuroscience, vol.199, pp.410-420, 2011.
DOI : 10.1016/j.neuroscience.2011.09.012

A. Rewerska, M. Pawelczyk, E. Rajkowska, P. Politanski, and M. Sliwinska-kowalska, Evaluating d-methionine dose to attenuate oxidative stress-mediated hearing loss following overexposure to noise, European Archives of Oto-Rhino-Laryngology, vol.3, issue.554, pp.1513-1520, 2013.
DOI : 10.1007/s00405-012-2265-3

P. P. Roux and J. Blenis, ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions, Microbiology and Molecular Biology Reviews, vol.68, issue.2, pp.320-344, 2004.
DOI : 10.1128/MMBR.68.2.320-344.2004

S. Roy, D. W. Nicholson, C. A. Whitworth, D. Mukherjea, and V. Ramkumar, Cross-Talk in Cell Death Signaling, The Journal of Experimental Medicine, vol.192, issue.8, pp.21-26, 2000.
DOI : 10.1084/jem.192.5.647

A. Sahara, M. Aoto, Y. Eguchi, N. Imamoto, Y. Yoneda et al., Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation, Nature, vol.401, pp.168-173, 1038.

S. Sakon, X. Xue, M. Takekawa, T. Sasazuki, T. Okazaki et al., NF-??B inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death, The EMBO Journal, vol.22, issue.15, pp.3898-3909, 2003.
DOI : 10.1093/emboj/cdg379

J. Samson, A. Wiktorek-smagur, P. Politanski, E. Rajkowska, M. Pawlaczyk-luszczynska et al., Noise-induced time-dependent changes in oxidative stress in the mouse cochlea and attenuation by d-methionine, Neuroscience, vol.152, issue.1, pp.146-150, 2008.
DOI : 10.1016/j.neuroscience.2007.11.015

H. Satoh, G. S. Firestein, P. B. Billings, J. P. Harris, and E. M. Keithley, Tumor Necrosis Factor-??, an Initiator, and Etanercept, an Inhibitor of Cochlear Inflammation, The Laryngoscope, vol.100, issue.9, pp.1627-1634, 2002.
DOI : 10.1097/00005537-200209000-00019

H. Satoh, G. S. Firestein, P. B. Billings, J. P. Harris, and E. M. Keithley, Proinflammatory Cytokine Expression in the Endolymphatic Sac During Inner Ear Inflammation, JARO - Journal of the Association for Research in Otolaryngology, vol.4, issue.2, pp.139-147, 2003.
DOI : 10.1007/s10162-002-3025-7

J. C. Saunders, S. P. Dear, and M. E. Schneider, The anatomical consequences of acoustic injury: A review and tutorial, The Journal of the Acoustical Society of America, vol.78, issue.3, pp.833-860, 1985.
DOI : 10.1121/1.392915

J. L. Scarlett and M. P. Murphy, Release of apoptogenic proteins form the mitochondrial intermembrane space during the mitochondrial permeability transition, FEBS Lett, vol.41897, pp.282-286, 1997.

T. W. Sedlak, Z. N. Oltvai, E. Yang, K. Wang, L. H. Boise et al., Multiple Bcl-2 family members demonstrate selective dimerizations with Bax., Proceedings of the National Academy of Sciences, vol.92, issue.17, pp.7834-7838, 1995.
DOI : 10.1073/pnas.92.17.7834

M. Seidman, S. Babu, W. Tang, E. Naem, and W. S. Quirk, Effects of resveratrol on acoustic trauma, Otolaryngology - Head and Neck Surgery, vol.129, issue.5, pp.463-470, 2003.
DOI : 10.1016/S0194-5998(03)01586-9

H. M. Shen and S. Pervaiz, TNF receptor superfamily-induced cell death: redox-dependent execution, The FASEB Journal, vol.20, issue.10, pp.1589-1598, 2006.
DOI : 10.1096/fj.05-5603rev

J. Silke and A. Strasser, The FLIP Side of Life, Science Signaling, vol.6, issue.258, 2013.
DOI : 10.1126/scisignal.2003845

K. Sinha, J. Das, P. B. Pal, and P. C. Sil, Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis, Archives of Toxicology, vol.9, issue.9, pp.1157-1180, 2013.
DOI : 10.1007/s00204-013-1034-4

D. I. Smith, M. Lawrence, J. E. Hawkins, and . Jr, Effects of noise and quinine on the vessels of the stria vascularis: An image analysis study, American Journal of Otolaryngology, vol.6, issue.4, pp.280-289, 1985.
DOI : 10.1016/S0196-0709(85)80056-9

H. So, H. Kim, J. H. Lee, C. Park, Y. Kim et al., Cisplatin Cytotoxicity of Auditory Cells Requires Secretions of Proinflammatory Cytokines via Activation of ERK and NF-??B, Journal of the Association for Research in Otolaryngology, vol.137, issue.Suppl 2, pp.338-355, 2007.
DOI : 10.1007/s10162-007-0084-9

H. Spoendlin, Primary Structural Changes in the Organ of Corti After Acoustic Overstimulation, Acta Oto-Laryngologica, vol.78, issue.1-6, pp.166-176, 1971.
DOI : 10.3109/00016487109125346

A. Stephanou, T. M. Scarabelli, B. K. Brar, Y. Nakanishi, M. Matsumura et al., Induction of Apoptosis and Fas Receptor/Fas Ligand Expression by Ischemia/Reperfusion in Cardiac Myocytes Requires Serine 727 of the STAT-1 Transcription Factor but Not Tyrosine 701, Journal of Biological Chemistry, vol.276, issue.30, pp.28340-28347, 1080.
DOI : 10.1074/jbc.M101177200

Y. Suzuki, Y. Imai, H. Nakayama, K. Takahashi, K. Takio et al., A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death, Molecular Cell, vol.8, issue.3, pp.613-621, 2001.
DOI : 10.1016/S1097-2765(01)00341-0

K. Tabuchi, K. Oikawa, T. Hoshino, B. Nishimura, K. Hayashi et al., Cochlear protection from acoustic injury by inhibitors of p38 mitogen-activated protein kinase and sequestosome 1 stress protein, Neuroscience, vol.166, issue.2, pp.665-670, 2010.
DOI : 10.1016/j.neuroscience.2009.12.038

K. Tabuchi, K. Pak, E. Chavez, R. , and A. F. , Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage, Neuroscience, vol.149, issue.1, pp.213-222, 2007.
DOI : 10.1016/j.neuroscience.2007.06.061

Y. Tahera, I. Meltser, P. Johansson, Z. Bian, P. Stierna et al., NF-??B mediated glucocorticoid response in the inner ear after acoustic trauma, Journal of Neuroscience Research, vol.202, issue.6, pp.1066-1076, 2006.
DOI : 10.1002/jnr.20795

L. A. Tartaglia, T. M. Ayres, G. H. Wong, and D. V. Goeddel, A novel domain within the 55 kd TNF receptor signals cell death, Cell, vol.74, issue.5, pp.845-853, 1993.
DOI : 10.1016/0092-8674(93)90464-2

D. D. Taub, P. Proost, W. J. Murphy, M. Anver, D. L. Longo et al., Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes., Journal of Clinical Investigation, vol.95, issue.3, pp.1370-1376, 1172.
DOI : 10.1172/JCI117788

C. T. Taylor, Mitochondria and cellular oxygen sensing in the HIF pathway, Biochemical Journal, vol.409, issue.1, pp.19-26, 2008.
DOI : 10.1042/BJ20071249

M. Teranishi, T. Nakashima, and T. Wakabayashi, Effects of ??-tocopherol on cisplatin-induced ototoxicity in guinea pigs, Hearing Research, vol.151, issue.1-2, pp.61-70, 2001.
DOI : 10.1016/S0300-2977(00)00080-2

L. Tourian, . Jr, H. Zhao, and C. B. Srikant, p38??, but not p38??, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling, Journal of Cell Science, vol.117, issue.26, pp.6459-6471, 2004.
DOI : 10.1242/jcs.01573

C. Tournier, P. Hess, D. D. Yang, J. Xu, T. K. Turner et al., Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway, Science, vol.288, issue.5467, pp.870-874, 2000.
DOI : 10.1126/science.288.5467.870

Y. Tsujimoto and S. Shimizu, Role of the mitochondrial membrane permeability transition in cell death, Apoptosis, vol.16, issue.Pt 1, pp.835-840, 2007.
DOI : 10.1007/s10495-006-0525-7

M. Tsujimoto, S. Yokota, J. Vilcek, and G. Weissmann, Tumor necrosis factor provokes superoxide anion generation from neutrophils, Biochemical and Biophysical Research Communications, vol.137, issue.3, pp.1094-1100, 1986.
DOI : 10.1016/0006-291X(86)90337-2

J. F. Turrens, Mitochondrial formation of reactive oxygen species, The Journal of Physiology, vol.552, issue.2, pp.335-344, 2003.
DOI : 10.1113/jphysiol.2003.049478

P. Vandenabeele, L. Galluzzi, T. Vanden-berghe, and G. Kroemer, Molecular mechanisms of necroptosis: an ordered cellular explosion, Nature Reviews Molecular Cell Biology, vol.274, issue.10, pp.700-714, 1038.
DOI : 10.1038/nrm2970

T. Vanden-berghe, A. Linkermann, S. Jouan-lanhouet, H. Walczak, P. F. Vandenabeele et al., Regulated necrosis: the expanding network of non-apoptotic cell death pathways, Nature Reviews Molecular Cell Biology, vol.24, issue.2, pp.135-147, 1159.
DOI : 10.1038/nrm3737

H. Wajant, K. Pfizenmaier, and P. Scheurich, Tumor necrosis factor signaling, Cell Death and Differentiation, vol.10, issue.1, pp.45-65, 2003.
DOI : 10.1038/sj.cdd.4401189

J. Wang, D. Ding, A. Shulman, A. Stracher, and R. J. Salvi, Leupeptin protects sensory hair cells from acoustic trauma, NeuroReport, vol.10, issue.4, pp.811-816, 1999.
DOI : 10.1097/00001756-199903170-00027

A. Wang, N. Hou, D. Bao, S. Liu, and T. Xu, Mechanism of alphalipoic acid in attenuating kanamycin-induced ototoxiciy, Neural Regen. Res, vol.7, pp.2793-2800, 2012.

Z. Wang, H. Jiang, S. Chen, F. Du, W. et al., The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways, Cell, vol.148, issue.1-2, pp.228-243, 2012.
DOI : 10.1016/j.cell.2011.11.030

Y. Wang, N. S. Kim, J. F. Haince, H. C. Kang, K. K. David et al., Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos), Science Signaling, vol.4, issue.167, 2011.
DOI : 10.1126/scisignal.2000902

X. T. Wang, D. S. Pei, J. Xu, Q. H. Guan, Y. F. Sun et al., Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury, Cellular Signalling, vol.19, issue.9, pp.1844-1856, 2007.
DOI : 10.1016/j.cellsig.2007.04.005

J. Wang, J. Ruel, S. Ladrech, C. Bonny, T. R. Van-de-water et al., Inhibition of the c-Jun N-Terminal Kinase-Mediated Mitochondrial Cell Death Pathway Restores Auditory Function in Sound-Exposed Animals, Molecular Pharmacology, vol.71, issue.3, pp.654-666, 2007.
DOI : 10.1124/mol.106.028936
URL : https://hal.archives-ouvertes.fr/inserm-00145399

J. Wang, T. R. Van-de-water, C. Bonny, F. De-ribaupierre, J. L. Puel et al., A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss, J. Neurosci, vol.23, pp.8596-8607, 2003.

J. Whitfield, S. J. Neame, L. Paquet, O. Bernard, and J. Ham, Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release, Neuron, vol.29, issue.3, pp.629-643, 2001.
DOI : 10.1016/S0896-6273(01)00239-2

P. Widlak, L. Y. Li, X. Wang, and W. T. Garrard, Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I, J. Biol. Chem, vol.276, pp.48404-48409, 2001.

H. Yamane, Y. Nakai, M. Takayama, K. Konishi, H. Iguchi et al., The Emergence of Free Radicals after Acoustic Trauma and Strial Blood Flow, Acta Oto-Laryngologica, vol.4, issue.sup519, pp.87-92, 1995.
DOI : 10.3109/00016489509121877

D. Yamashita, H. Y. Jiang, J. Schacht, and J. M. Miller, Delayed production of free radicals following noise exposure, Brain Research, vol.1019, issue.1-2, pp.201-209, 2004.
DOI : 10.1016/j.brainres.2004.05.104

D. Yamashita, J. M. Miller, H. Y. Jiang, S. B. Minami, and J. Schacht, AIF and EndoG in noise-induced hearing loss, Neuroreport, vol.15, pp.2719-2722, 2004.

W. P. Yang, D. Henderson, B. H. Hu, and T. M. Nicotera, Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise, Hearing Research, vol.196, issue.1-2, pp.69-76, 2004.
DOI : 10.1016/j.heares.2004.04.015

J. Ylikoski, L. Xing-qun, J. Virkkala, U. K. Pirvola, I. Ichimiya et al., Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death, Hearing Research, vol.163, issue.1-2, pp.71-81, 1999.
DOI : 10.1016/S0378-5955(01)00380-X

S. W. Yu, S. A. Andrabi, H. Wang, N. S. Kim, G. G. Poirier et al., Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death, Proceedings of the National Academy of Sciences, vol.103, issue.48, pp.18314-18319, 2006.
DOI : 10.1073/pnas.0606528103

D. W. Zhang, J. Shao, J. Lin, N. Zhang, B. J. Lu et al., RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis, Science, vol.325, issue.5938, pp.332-336, 2009.
DOI : 10.1126/science.1172308

H. W. Zheng, J. Chen, S. , and S. H. , Receptor-interacting protein kinases modulate noise-induced sensory hair cell death, Cell Death and Disease, vol.23, issue.5, 2014.
DOI : 10.1038/cdd.2011.96

J. Zou, I. Pyykkö, P. Sutinen, and E. Toppila, Vibration induced hearing loss in guinea pig cochlea: expression of TNF-?? and VEGF, Hearing Research, vol.202, issue.1-2, pp.13-20, 2005.
DOI : 10.1016/j.heares.2004.10.008