F. Smithuis, M. Kyaw, O. Phe, K. Aye, L. Htet et al., Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison, The Lancet, vol.367, issue.9528, pp.2075-85, 2006.
DOI : 10.1016/S0140-6736(06)68931-9

N. Thang, T. Trung, N. Phong, H. Quang, B. Dai et al., The efficacy and tolerability of artemisinin-piperaquine (Artequick) versus artesunate-amodiaquine (Coarsucam) for the treatment of uncomplicated Plasmodium falciparum malaria in south-central Vietnam

K. Sylla, A. Abiola, R. Tine, F. B. Sow, D. Ndiaye et al., Monitoring the efficacy and safety of three artemisinin based-combinations therapies in Senegal: results from two years surveillance, BMC Infectious Diseases, vol.11, issue.5, p.598, 2013.
DOI : 10.1186/1475-2875-11-184

W. Yavo, F. B. Kuete, T. Djohan, V. Oga, S. Kassi et al., Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa, Malaria Journal, vol.10, issue.1, p.198, 2011.
DOI : 10.1016/j.trstmh.2007.05.018

A. Yeka, J. Tibenderana, J. Achan, D. 'alessandro, U. Talisuna et al., Efficacy of Quinine, Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine as Rescue Treatment for Uncomplicated Malaria in Ugandan Children, PLoS ONE, vol.379, issue.9, p.53772, 2013.
DOI : 10.1371/journal.pone.0053772.s005

A. Agarwal, M. Mcmorrow, P. Onyango, K. Otieno, C. Odero et al., A randomized trial of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated malaria among children in western Kenya, Malaria Journal, vol.12, issue.1, p.254, 2013.
DOI : 10.1186/1475-2875-10-209

A. Yeka, G. Dorsey, M. Kamya, A. Talisuna, M. Lugemwa et al., Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treating Uncomplicated Malaria: A Randomized Trial to Guide Policy in Uganda, PLoS ONE, vol.360, issue.6, p.2390, 2008.
DOI : 10.1371/journal.pone.0002390.s002

M. Kamya, A. Yeka, H. Burkirwa, M. Lugemwa, J. Rwakimari et al., Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial, PLoS Clinical Trials, vol.2, issue.5, p.20, 2007.
DOI : 10.1371/journal.pctr.0020020.sd002

I. Zongo, G. Dorsey, N. Rouamba, C. Dokomajilar, Y. Séré et al., Randomized Comparison of Amodiaquine plus Sulfadoxine-Pyrimethamine, Artemether-Lumefantrine, and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Burkina Faso, Clinical Infectious Diseases, vol.45, issue.11, pp.1453-61, 2007.
DOI : 10.1086/522985

A. Hasugian, H. Purba, E. Kenangalem, R. Wuwung, E. Ebsworth et al., Dihydroartemisinin-Piperaquine versus Artesunate-Amodiaquine: Superior Efficacy and Posttreatment Prophylaxis against Multidrug-Resistant Plasmodium falciparum and Plasmodium vivax Malaria, Clinical Infectious Diseases, vol.44, issue.8, pp.1067-74, 2008.
DOI : 10.1086/512677

A. Pasaribu, W. Chokejindachai, C. Sirivichayakul, N. Tanomsing, I. Chavez et al., A Randomized Comparison of Dihydroartemisinin-Piperaquine and Artesunate-Amodiaquine Combined With Primaquine for Radical Treatment of Vivax Malaria in Sumatera, Indonesia, Journal of Infectious Diseases, vol.208, issue.11, pp.1906-1919, 2013.
DOI : 10.1093/infdis/jit407

R. Leang, A. Barrette, M. Bouth, D. Menard, D. Abdur et al., Efficacy of Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010, Antimicrobial Agents and Chemotherapy, vol.57, issue.2, pp.818-844, 2008.
DOI : 10.1128/AAC.00686-12

D. Saunders, P. Vanachayangkul, and C. Lon, Dihydroartemisinin???Piperaquine Failure in Cambodia, New England Journal of Medicine, vol.371, issue.5, pp.484-489, 2014.
DOI : 10.1056/NEJMc1403007

K. Thriemer, V. Hong, N. Rosanas-urgell, A. Ha, D. Pockele et al., Delayed Parasite Clearance after Treatment with Dihydroartemisinin-Piperaquine in Plasmodium falciparum Malaria Patients in Central Vietnam, Antimicrobial Agents and Chemotherapy, vol.58, issue.12, pp.7049-55, 2014.
DOI : 10.1128/AAC.02746-14

A. Pascual, M. Madamet, L. Bertaux, R. Amalvict, N. Benoit et al., In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene, Malaria Journal, vol.12, issue.1, p.431, 2013.
DOI : 10.1128/AAC.01793-10
URL : https://hal.archives-ouvertes.fr/inserm-00911243

A. Pascual, P. Parola, F. Benoit-vical, F. Simon, D. Malvy et al., Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum, Malaria Journal, vol.11, issue.1, p.45, 2012.
DOI : 10.1128/AAC.49.12.5127-5128.2005
URL : https://hal.archives-ouvertes.fr/pasteur-00836167

L. Basco and P. Ringwald, In Vitro Activities of Piperaquine and Other 4-Aminoquinolines against Clinical Isolates of Plasmodium falciparum in Cameroon, Antimicrobial Agents and Chemotherapy, vol.47, issue.4, pp.1391-1395, 2003.
DOI : 10.1128/AAC.47.4.1391-1394.2003

J. Okombo, A. Abdi, S. Kiara, L. Mwai, L. Pole et al., Repeat Polymorphisms in the Low-Complexity Regions of Plasmodium falciparum ABC Transporters and Associations with In Vitro Antimalarial Responses, Antimicrobial Agents and Chemotherapy, vol.57, issue.12, pp.6196-204, 2013.
DOI : 10.1128/AAC.01465-13

J. Okombo, S. Kiara, L. Mwai, L. Pole, E. Ohuma et al., Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya, Antimicrobial Agents and Chemotherapy, vol.56, issue.2, pp.1105-1112, 2012.
DOI : 10.1128/AAC.05454-11

L. Mwai, S. Kiara, A. Abdirahman, L. Pole, A. Rippert et al., In Vitro Activities of Piperaquine, Lumefantrine, and Dihydroartemisinin in Kenyan Plasmodium falciparum Isolates and Polymorphisms in pfcrt and pfmdr1, Antimicrobial Agents and Chemotherapy, vol.53, issue.12, pp.5069-73, 2009.
DOI : 10.1128/AAC.00638-09

M. Issaka, A. Salissou, I. Arzika, J. Guillebaud, A. Maazou et al., Ex Vivo Responses of Plasmodium falciparum Clinical Isolates to Conventional and New Antimalarial Drugs in Niger, Antimicrobial Agents and Chemotherapy, vol.57, issue.7, pp.3415-3424, 2013.
DOI : 10.1128/AAC.02383-12

N. Quashie, N. Duah, B. Abuaku, L. Quaye, R. Ayanful-torgby et al., A SYBR Green 1-based in vitro test of susceptibility of Ghanaian Plasmodium falciparum clinical isolates to a panel of anti-malarial drugs, Malaria Journal, vol.12, issue.1, p.450, 2013.
DOI : 10.1186/1475-2875-12-450

S. Nsobya, M. Kiggundu, S. Nanyunja, M. Joloba, B. Greenhouse et al., In Vitro Sensitivities of Plasmodium falciparum to Different Antimalarial Drugs in Uganda, Antimicrobial Agents and Chemotherapy, vol.54, issue.3, pp.1200-1206, 2010.
DOI : 10.1128/AAC.01412-09

M. Hao, D. Jia, Q. Li, Y. He, L. Yuan et al., In Vitro Sensitivities of Plasmodium falciparum Isolates from the China-Myanmar Border to Piperaquine and Association with Polymorphisms in Candidate Genes, Antimicrobial Agents and Chemotherapy, vol.57, issue.4, pp.1723-1732, 2013.
DOI : 10.1128/AAC.02306-12

M. Barends, A. Jaidee, N. Khaohirun, P. Singhasivanon, and F. Nosten, In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border, Malaria Journal, vol.6, issue.1, p.81, 2007.
DOI : 10.1186/1475-2875-6-81

P. Lim, D. Dek, V. Try, R. Eastman, S. Chy et al., Ex Vivo Susceptibility of Plasmodium falciparum to Antimalarial Drugs in Western, Northern, and Eastern Cambodia, 2011-2012: Association with Molecular Markers, Antimicrobial Agents and Chemotherapy, vol.57, issue.11, pp.5277-83, 2013.
DOI : 10.1128/AAC.00687-13

J. Marfurt, F. Chalfein, P. Prayoga, F. Wabiser, E. Kenangalem et al., Ex Vivo Drug Susceptibility of Ferroquine against Chloroquine-Resistant Isolates of Plasmodium falciparum and P. vivax, Antimicrobial Agents and Chemotherapy, vol.55, issue.9, pp.4461-4465, 2011.
DOI : 10.1128/AAC.01375-10

R. Wong, D. Lautu, L. Tavul, S. Hackett, P. Siba et al., to conventional and novel antimalarial drugs in Papua New Guinea, Tropical Medicine & International Health, vol.2, issue.Suppl. 4, pp.342-351, 2010.
DOI : 10.1111/j.1365-3156.2009.02463.x

S. Looareesuwan, D. Kyle, C. Vivaran, S. Vanijanonta, P. Wilairatana et al., Clinical study of pyronaridine for the treatment of acute uncomplicated falciparum malaria in Thailand, Am J Trop Med Hyg, vol.54, pp.205-214, 1996.

A. Tshefu, O. Gaye, K. Kayentao, R. Thompson, K. Bhatt et al., Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial, The Lancet, vol.375, issue.9724, pp.1457-67, 2010.
DOI : 10.1016/S0140-6736(10)60322-4

K. Kayentao, O. Doumbo, L. Pénali, A. Offianan, K. Bhatt et al., Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial, Malaria Journal, vol.11, issue.1, p.364, 2012.
DOI : 10.1016/S1473-3099(09)70327-5

R. Rueangweerayu, A. Phyo, C. Uthaisin, Y. Poravuth, T. Binh et al., Pyronaridine???Artesunate versus Mefloquine plus Artesunate for Malaria, New England Journal of Medicine, vol.366, issue.14, pp.1298-309, 2012.
DOI : 10.1056/NEJMoa1007125

B. Pradines, S. Briolant, M. Henry, C. Oeuvray, E. Baret et al., Absence of association between pyronaridine in vitro responses and polymorphisms in genes involved in quinoline resistance in Plasmodium falciparum, Malaria Journal, vol.9, issue.1, p.337, 2010.
DOI : 10.1186/1475-2875-9-339

P. Ringwald, M. Eboumbou, C. Bickii, J. Basco, and L. , In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum, Antimicrob Agents Chemother, vol.43, pp.1525-1532, 1999.

B. Pradines, M. Mamfoumbi, M. Parzy, D. , O. Medang et al., In vitro susceptibility of African isolates of Plasmodium falciparum from Gabon to pyronaridine, Am J Trop Med Hyg, vol.60, pp.105-113, 1999.

F. Kurth, P. Pongratz, S. Bélard, B. Mordmüller, P. Kremsner et al., In vitro activity of pyronaridine against Plasmodium falciparum and comparative evaluation of anti-malarial drug susceptibility assays, Malaria Journal, vol.8, issue.1, p.79, 2009.
DOI : 10.1186/1475-2875-8-79

B. Pradines, A. Tall, D. Parzy, A. Spiegel, T. Fusai et al., In-vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents., Journal of Antimicrobial Chemotherapy, vol.42, issue.3, pp.333-342, 1998.
DOI : 10.1093/jac/42.3.333

B. Pradines, A. Tall, F. Ramiandrasoa, A. Spiegel, C. Sokhna et al., In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum, Journal of Antimicrobial Chemotherapy, vol.57, issue.6, pp.1093-1102, 2006.
DOI : 10.1093/jac/dkl117

R. Price, J. Marfurt, F. Chalfein, E. Kenagalem, K. Piera et al., In Vitro Activity of Pyronaridine against Multidrug-Resistant Plasmodium falciparum and Plasmodium vivax, Antimicrobial Agents and Chemotherapy, vol.54, issue.12, pp.5146-50, 2010.
DOI : 10.1128/AAC.00801-10

C. Lambros and J. Vanderberg, Synchronization of Plasmodium falciparum Erythrocytic Stages in Culture, The Journal of Parasitology, vol.65, issue.3, pp.418-438, 1979.
DOI : 10.2307/3280287

H. Bogreau, F. Renaud, H. Bouchiba, P. Durand, S. Assi et al., Genetic diversity and structure of African Plasmodium falciparum populations in urban and rural areas, Am J Trop Med Hyg, vol.74, pp.953-962, 2006.

M. Henry, I. Diallo, J. Bordes, S. Ka, B. Pradines et al., Urban malaria in Dakar, Senegal: chemosusceptibility and genetic diversity of Plasmodium falciparum isolates, Am J Trop Med Hyg, vol.75, pp.146-51, 2006.

S. Richardson and P. Green, On Bayesian Analysis of Mixtures with an Unknown Number of Components (with discussion), Journal of the Royal Statistical Society: Series B (Statistical Methodology), vol.59, issue.4, pp.731-92, 1997.
DOI : 10.1111/1467-9868.00095

O. Cappé, C. Robert, and T. Rydén, Reversible jump, birth-and-death and more general continuous time Markov chain Monte Carlo samplers, Journal of the Royal Statistical Society: Series B (Statistical Methodology), vol.28, issue.3, pp.679-700, 2003.
DOI : 10.1111/1467-9868.00219

J. Diebolt and C. Robert, Estimation of finite mixture distributions through Bayesian sampling, J Roy Stat Soc, vol.56, pp.363-75, 1994.

A. Jasra, C. Holmes, and D. Stephens, Markov Chain Monte Carlo Methods and the Label Switching Problem in Bayesian Mixture Modeling, Statistical Science, vol.20, issue.1, pp.50-67, 2005.
DOI : 10.1214/088342305000000016

C. Sibley, K. Barnes, and C. Plowe, The rationale and plan for creating a World Antimalarial Resistance Network (WARN), Malaria Journal, vol.6, issue.1, p.118, 2007.
DOI : 10.1186/1475-2875-6-118

C. Sibley, K. Barnes, W. Watkins, and C. Plowe, A network to monitor antimalarial drug resistance: a plan for moving forward, Trends in Parasitology, vol.24, issue.1, pp.43-51, 2008.
DOI : 10.1016/j.pt.2007.09.008

D. Bacon, R. Jambou, T. Fandeur, L. Bras, J. Wongsrichanalai et al., World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility, Malaria Journal, vol.74, issue.6, p.120, 2007.
DOI : 10.1086/320707

C. Plowe, C. Rooper, J. Barnwell, C. Happi, H. Joshi et al., World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria, Malaria Journal, vol.75, issue.Suppl, p.121, 2007.
DOI : 10.1016/S0166-6851(97)00247-8

S. Briolant, M. Baragatti, P. Parola, F. Simon, A. Tall et al., Multinormal In Vitro Distribution Model Suitable for the Distribution of Plasmodium falciparum Chemosusceptibility to Doxycycline, Antimicrobial Agents and Chemotherapy, vol.53, issue.2, pp.688-95, 2009.
DOI : 10.1128/AAC.00546-08

T. Gaillard, S. Briolant, S. Houzé, M. Baragatti, N. Wurtz et al., PftetQ and pfmdt copy numbers as predictive molecular markers of decreased ex vivo doxycycline susceptibility in imported Plasmodium falciparum malaria, Malaria Journal, vol.12, issue.1, p.414, 2013.
DOI : 10.1111/j.1469-0691.2012.03889.x
URL : https://hal.archives-ouvertes.fr/inserm-00905251

A. Divo, T. Geary, and J. Jensen, Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture., Antimicrobial Agents and Chemotherapy, vol.27, issue.1, pp.21-28, 1985.
DOI : 10.1128/AAC.27.1.21

A. Pascual, L. Basco, E. Baret, R. Amalvict, D. Travers et al., Use of the atmospheric generators for capnophilic bacteria Genbag-CO2 for the evaluation of in vitro Plasmodium falciparum susceptibility to standard anti-malarial drugs, Malaria Journal, vol.10, issue.1, p.8, 2011.
DOI : 10.1186/1475-2875-10-8

B. Fall, S. Diawara, K. Sow, E. Baret, B. Diatta et al., Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs, Malaria Journal, vol.10, issue.1, p.310, 2011.
DOI : 10.1128/AAC.45.6.1746-1750.2001

S. Wein, M. Mynadier, T. Van-ba, C. Cerdan, R. Peyrottes et al., Reliability of Antimalarial Sensitivity Tests Depends on Drug Mechanisms of Action, Journal of Clinical Microbiology, vol.48, issue.5, pp.1651-60, 2010.
DOI : 10.1128/JCM.02250-09
URL : https://hal.archives-ouvertes.fr/hal-00501621

B. Pradines, C. Rogier, T. Fusai, J. Mosnier, W. Daries et al., In Vitro Activities of Antibiotics against Plasmodium falciparum Are Inhibited by Iron, Antimicrobial Agents and Chemotherapy, vol.45, issue.6, pp.1746-50, 2001.
DOI : 10.1128/AAC.45.6.1746-1750.2001

A. Sidhu, Q. Sun, L. Nkrumah, M. Dunne, J. Sacchettini et al., In Vitro Efficacy, Resistance Selection, and Structural Modeling Studies Implicate the Malarial Parasite Apicoplast as the Target of Azithromycin, Journal of Biological Chemistry, vol.282, issue.4, pp.2494-504, 2007.
DOI : 10.1074/jbc.M608615200

S. Briolant, P. Parola, T. Fusai, M. Madamet-torrentino, E. Baret et al., Influence of oxygen on asexual blood cycle and susceptibility of Plasmodium falciparum to chloroquine: requirement of a standardized in vitro assay, Malaria Journal, vol.6, issue.1, p.44, 2007.
DOI : 10.1186/1475-2875-6-44

B. Pradines, A. Tall, T. Fusai, A. Spiegel, R. Hienne et al., In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs, Antimicrob Agents Chemother, vol.43, pp.418-438, 1999.

S. Muangnoicharoen, D. Johnson, S. Looareesuwan, S. Krudsood, and S. Ward, Role of Known Molecular Markers of Resistance in the Antimalarial Potency of Piperaquine and Dihydroartemisinin In Vitro, Antimicrobial Agents and Chemotherapy, vol.53, issue.4, pp.1362-1368, 2009.
DOI : 10.1128/AAC.01656-08

S. Hofer, R. Brun, S. Maerki, H. Matile, C. Scheurer et al., In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum, Journal of Antimicrobial Chemotherapy, vol.62, issue.5, pp.1061-1065, 2008.
DOI : 10.1093/jac/dkn315

H. Tinto, L. Bonkian, L. Nana, I. Yerbanga, M. Lingani et al., Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change, Malaria Journal, vol.13, issue.1, p.207, 2014.
DOI : 10.1016/S1473-3099(13)70252-4

S. Tyner, C. Lon, Y. Se, D. Bethell, D. Socheat et al., Ex vivo drug sensitivity profiles of Plasmodium falciparum field isolates from Cambodia and Thailand, Malar J, vol.11, 0198.

P. Sawa, S. Shekalaghe, C. Drakeley, C. Sutherland, C. Mweresa et al., Malaria Transmission After Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine: A Randomized Trial, Journal of Infectious Diseases, vol.207, issue.11, pp.1637-1682, 2013.
DOI : 10.1093/infdis/jit077

M. Onyamboko, C. Fanello, K. Wongsaen, J. Tarning, P. Cheah et al., Randomized Comparison of the Efficacies and Tolerabilities of Three Artemisinin-Based Combination Treatments for Children with Acute Plasmodium falciparum Malaria in the Democratic Republic of the Congo, Antimicrobial Agents and Chemotherapy, vol.58, issue.9, pp.5528-5564, 2014.
DOI : 10.1128/AAC.02682-14

H. Wanzira, A. Kakuru, E. Arinaitwe, V. Bigira, M. Muhindo et al., Longitudinal Outcomes in a Cohort of Ugandan Children Randomized to Artemether-Lumefantrine Versus Dihydroartemisinin-Piperaquine for the Treatment of Malaria, Clinical Infectious Diseases, vol.59, issue.4, pp.509-525, 2014.
DOI : 10.1093/cid/ciu353

C. Naing, V. Racloz, M. Whittaker, K. Aung, S. Reid et al., Efficacy and Safety of Dihydroartemisinin-Piperaquine for Treatment of Plasmodium vivax Malaria in Endemic Countries: Meta-Analysis of Randomized Controlled Studies, PLoS ONE, vol.56, issue.12, p.78819, 2013.
DOI : 10.1371/journal.pone.0078819.s003

P. Henrich, O. Brien, C. Sáenz, F. Cremers, S. Kyle et al., Evidence for Pyronaridine as a Highly Effective Partner Drug for Treatment of Artemisinin-Resistant Malaria in a Rodent Model, Antimicrobial Agents and Chemotherapy, vol.58, issue.1, pp.183-95, 2014.
DOI : 10.1128/AAC.01466-13