Enamine Activation of beta-Ketocarbonyls: New Opportunities in Enantioselective Organocatalysis

Jean Rodriguez (1) , Yoann Coquerel (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

Enamine activation of alpha-branched beta-ketocarbonyl compounds is actually possible, very efficient, and highly enantioselective with a bifunctional primary amine/tertiary ammonium triflate salt catalyst. This covalent HOMO activation mode competes with existing strategies for the enantioselective activation of beta-ketocarbonyls and their analogues.

Mots clés: 1; 3-dicarbonyls; enantioselective catalysis; enantioselectivity; organocatalysis; synthetic methods

Domaines: Chimie organique

Jean Rodriguez, Yoann Coquerel. Enamine Activation of beta-Ketocarbonyls: New Opportunities in Enantioselective Organocatalysis. ChemCatChem, 2015, 7, pp.1263. ⟨10.1002/cctc.201500159⟩. ⟨hal-01224298⟩