The Thymus-Specific Serine Protease TSSP/PRSS16 Is Crucial for the Antitumoral Role of CD4

Lydie Brisson (1) , Laurent Pouyet (1) , Prudence N’guessan (1, 2) , Stéphane Garcia (1) , Noëlla Lopes (1) , Gilles Warcollier (3) , Juan L Iovanna (1) , Alice Carrier (1)

1 CRCM - Centre de Recherche en Cancérologie de Marseille
2 CIML - Centre d'Immunologie de Marseille - Luminy
3 CIPHE - Centre d'Immunophénomique

Graphical Abstract Highlights d TSSP is an important protease for intrathymic selection of CD4 + T cells d Absence of TSSP favors both spontaneous and inflammation-induced tumor development d TSSP-dependent maturation of CD4 + T cells in the thymus is required for tumor suppression d TSSP is a thymic protease with tumor suppressor activity

Mots clés: COLITIS-ASSOCIATED CANCER; COLON CARCINOGENESIS; IMMUNE SURVEILLANCE; COLORECTAL-CANCER; GENE-EXPRESSION; INFLAMMATION; MICE; IMMUNOSURVEILLANCE; IMMUNOTHERAPY; CD3-EPSILON

Domaines: Cancer

Lydie Brisson, Laurent Pouyet, Prudence N’guessan, Stéphane Garcia, Noëlla Lopes, et al.. The Thymus-Specific Serine Protease TSSP/PRSS16 Is Crucial for the Antitumoral Role of CD4. Cell Reports, 2015, 10, pp.39-46. ⟨10.1016/j.celrep.2014.12.009⟩. ⟨hal-01230365⟩