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The Thymus-Specific Serine Protease TSSP/PRSS16 Is Crucial for the Antitumoral Role of CD4

Lydie Brisson 1 Laurent Pouyet 1 Prudence N’guessan 1, 2 Stéphane Garcia 1 Noëlla Lopes 1 Gilles Warcollier 3 Juan L Iovanna 1 Alice Carrier 1
1 CRCM - Centre de Recherche en Cancérologie de Marseille
2 CIML - Centre d'Immunologie de Marseille - Luminy
3 CIPHE - Centre d'Immunophénomique
Abstract : Graphical Abstract Highlights d TSSP is an important protease for intrathymic selection of CD4 + T cells d Absence of TSSP favors both spontaneous and inflammation-induced tumor development d TSSP-dependent maturation of CD4 + T cells in the thymus is required for tumor suppression d TSSP is a thymic protease with tumor suppressor activity
Keywords : COLITIS-ASSOCIATED CANCER COLON CARCINOGENESIS IMMUNE SURVEILLANCE COLORECTAL-CANCER GENE-EXPRESSION INFLAMMATION MICE IMMUNOSURVEILLANCE IMMUNOTHERAPY CD3-EPSILON
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https://hal-amu.archives-ouvertes.fr/hal-01230365
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Submitted on : Wednesday, November 18, 2015 - 11:33:10 AM
Last modification on : Friday, October 22, 2021 - 3:34:48 AM
Long-term archiving on: : Friday, April 28, 2017 - 8:46:11 PM

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Lydie Brisson, Laurent Pouyet, Prudence N’guessan, Stéphane Garcia, Noëlla Lopes, et al.. The Thymus-Specific Serine Protease TSSP/PRSS16 Is Crucial for the Antitumoral Role of CD4. Cell Reports, Elsevier Inc, 2015, 10, pp.39-46. ⟨10.1016/j.celrep.2014.12.009⟩. ⟨hal-01230365⟩

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