Skip to Main content Skip to Navigation
Journal articles

Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study

Abstract : The association between fluid intake and bladder cancer risk remains controversial. Very little is known about to which extent the amount of water intake influences the action of excreting toxics upon the urinary system. This proof of concept trial investigates the effect of water intake on mutagenesis in smokers, a high risk population for bladder cancer. Methods. Monocentric randomized controlled trial. Inclusion Criteria. Male subjects aged 20–45 y/o, smokers, and small drinkers (24-hour urinary volume <1 L and osmolality >700 mOsmol/kg). Outcomes. 4-ABP DNA adducts formation in exfoliated bladder cells in 24-hour urine collection and urinary mutagenicity in 24-hour urine. Test Group. Subjects consumed 1.5 L daily of the study product (EVIAN) on top of their usual water intake for 50 days. Control Group. Subjects continued their usual lifestyle habits. Results. 65 subjects were randomized. Mean age was 30 y/o and mean cigarettes per day were 20. A slight decrease in adducts formation was observed between baseline and last visit but no statistically significant difference was demonstrated between the groups. Urinary mutagenicity significantly decreased. The study shows that increasing water intake decreases urinary mutagenicity. It is not confirmed by urinary adducts formation. Further research would be necessary.
Complete list of metadatas

Cited literature [19 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-01231176
Contributor : Administrateur Hal Amu <>
Submitted on : Thursday, November 19, 2015 - 3:49:00 PM
Last modification on : Tuesday, January 14, 2020 - 10:38:11 AM
Long-term archiving on: : Friday, April 28, 2017 - 2:58:03 PM

File

478150.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Inmaculada Buendia Jimenez, Pascaline Richardot, Pascaline Picard, Eve M Lepicard, Michel de Meo, et al.. Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study. Disease Markers, IOS Press, 2015, ⟨10.1155/2015/478150⟩. ⟨hal-01231176⟩

Share

Metrics

Record views

332

Files downloads

282