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Editorial Immunology and Infection by Protozoan Parasites

Abstract : Protozoan infection is the cause of diseases of high morbidity and mortality. Most are non-self-limiting chronic infections and neglected diseases; emergent antimicrobial-resistant strains pose a substantial problem; for many of them treatment either is highly toxic or has limited effectiveness. Vaccine development is still a formidable task and there is no licensed vaccine for human protozoan infection. The key to the control of protozoan infection is the understanding of the host immune response to protozoan parasites, which will guide the development of effective vaccines and immunother-apeutic agents. In this special issue, there are important studies on the immunology of T. cruzi infection, tegumentary and visceral leishmaniasis, malaria, and toxoplasmosis, both in patients and in animal models, which promote the understanding of immunopathological/immunoprotective parameters in these diseases. The reviews by J. M. ´ Alvarez and colleagues and by E. Cunha-Neto and C. Chevillard cover fundamental findings, mechanisms, and questions concerning the immune response and pathology of mouse and human disease. In this line, L. G. Nogueira and colleagues characterize the myocardial expression of transcriptional factors involved in effector CD4+ T cell differentiation and the characteristic cytokines produced by the distinct lymphocyte subsets and demonstrate a profound predominance of local Th1 response. L. C. J. Abel and coworkers characterized the proinflammatory effects of glicophosphatidyl inositol-anchored T. cruzi mucin (GPI-mucins) on human immune cells. It was observed that IL-12 production by GPI-mucins was dependent on IFN-í µí»¾ and CD40-CD40L interactions. F. C. Dias and colleagues investigated the HLA-G expression in tissues and HLA-G 147 3 í® í° UTR polymorphic site typing in patients presenting
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Submitted on : Tuesday, November 24, 2015 - 3:16:31 PM
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Edecio Cunha-Neto, Christophe Chevillard, Mauricio Martins Rodrigues, Marcelo T. Bozza. Editorial Immunology and Infection by Protozoan Parasites. Mediators of Inflammation, Hindawi Publishing Corporation, 2015, ⟨10.1155/2015/504951⟩. ⟨hal-01233127⟩

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