Skip to Main content Skip to Navigation
Journal articles

Circulating MicroRNAs as Clinical Biomarkers in the Predictions of Pregnancy Complications

Abstract : Predicting pregnancy complications is a major topic for clinicians and biologists for maternal and fetal monitoring. Noninvasive biomarkers in maternal blood such as circulating microRNAs (miRNAs) are promising molecules to predict pregnancy disorders. miRNAs are noncoding short RNAs that regulate mRNA expression by repressing the translation or cleaving the transcript. miRNAs are released to the extracellular systemic circulation via exosomes. The discovery of plasma-or serum-derived miRNAs and of free-circulating exosomes that contain miRNAs provides useful information about the physiological or pathophysiological roles of the miRNAs. Specific placental miRNAs are present in maternal plasma in different ways depending on whether the pregnancy is normal or pathological or if there is no pregnancy. This paper focuses on placental miRNAs and extracellular miRNAs to the placenta whose misregulation could lead to pregnancy complications.
Document type :
Journal articles
Complete list of metadata

Cited literature [64 references]  Display  Hide  Download
Contributor : Administrateur HAL AMU Connect in order to contact the contributor
Submitted on : Friday, November 27, 2015 - 10:30:31 AM
Last modification on : Friday, October 22, 2021 - 3:30:33 AM
Long-term archiving on: : Saturday, April 29, 2017 - 2:06:53 AM


Publisher files allowed on an open archive




Marthe Tsochandaridis, Laurent Nasca, Caroline Toga, Annie Levy-Mozziconacci. Circulating MicroRNAs as Clinical Biomarkers in the Predictions of Pregnancy Complications. BioMed Research International , Hindawi Publishing Corporation, 2015, ⟨10.1155/2015/294954⟩. ⟨hal-01234617⟩



Record views


Files downloads