Circulating MicroRNAs as Clinical Biomarkers in the Predictions of Pregnancy Complications

Marthe Tsochandaridis (1, 2) , Laurent Nasca (3, 2) , Caroline Toga (1, 3, 2) , Annie Levy-Mozziconacci (2, 1, 3)

1 Laboratoire de Biochimie et Biologie Moléculaire, Unité de Biologie Materno-Foetale
2 AMU - Aix Marseille Université
3 Centre Pluridisciplinaire de Diagnostic Prénatal

Predicting pregnancy complications is a major topic for clinicians and biologists for maternal and fetal monitoring. Noninvasive biomarkers in maternal blood such as circulating microRNAs (miRNAs) are promising molecules to predict pregnancy disorders. miRNAs are noncoding short RNAs that regulate mRNA expression by repressing the translation or cleaving the transcript. miRNAs are released to the extracellular systemic circulation via exosomes. The discovery of plasma-or serum-derived miRNAs and of free-circulating exosomes that contain miRNAs provides useful information about the physiological or pathophysiological roles of the miRNAs. Specific placental miRNAs are present in maternal plasma in different ways depending on whether the pregnancy is normal or pathological or if there is no pregnancy. This paper focuses on placental miRNAs and extracellular miRNAs to the placenta whose misregulation could lead to pregnancy complications.

Mots clés: PLACENTA-SPECIFIC MICRORNAS; FETAL-GROWTH RESTRICTION; TROPHOBLAST CELL-PROLIFERATION; MATERNAL PLASMA; INHIBITS PROLIFERATION; C19MC MICRORNAS; MESSENGER-RNAS; GENE-CLUSTER; PREECLAMPSIA; EXPRESSION

Domaines: Biologie de la reproduction

Marthe Tsochandaridis, Laurent Nasca, Caroline Toga, Annie Levy-Mozziconacci. Circulating MicroRNAs as Clinical Biomarkers in the Predictions of Pregnancy Complications. BioMed Research International , 2015, 294954, ⟨10.1155/2015/294954⟩. ⟨hal-01234617⟩