1. , C. Ch-)-s, 1. , and C. , 2-one (7j) unlike-isomer: Beige solid; mp 211 °C08 (s, 1H, CH). 13 C-NMR (CDCl3): ? 26, CDCl3): ? 3.33 (s, 3H, NCH3), 3.59 (s, 3H, NCH3), 5.18 (s, 1H, CH), 6.01 (d, J = 7.5 Hz, pp.71-141

T. Fukaya, T. Ishiyama, S. Baba, and S. Masumoto, Identification of a Novel Benzoxazolone Derivative as a Selective, Orally Active 18 kDa Translocator Protein (TSPO) Ligand, Journal of Medicinal Chemistry, vol.56, issue.20, pp.8191-8195, 2013.
DOI : 10.1021/jm401325r

H. Aichaoui, J. H. Poupaert, D. Lesieur, and J. Henichart, Regioselectivity in the c-acylation of 2(3H)-benzoxazolones, Tetrahedron, vol.47, issue.33, pp.47-6649, 1991.
DOI : 10.1016/S0040-4020(01)82317-6

Z. Moussavi, P. Depreux, D. Lesieur, N. Cotelle, J. Sauzieres et al., Pharmacomodulation of 7-(2-methylenebutyryl)-2,3-dihydrobenzoxazin-[1,4]-3-one structure and normolipemic activity, Farmaco, vol.46, pp.339-355, 1991.

H. Ucar, K. Van-derpoorten, S. Cacciaguerra, S. Spampinato, J. P. Stables et al., )-Benzothiazolone Derivatives, Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives, pp.1138-1145, 1998.
DOI : 10.1021/jm970682+

M. Courtois, Z. Mincheva, F. Andreu, M. Rideau, and M. C. Viaud-massuard, Synthesis and Biological Evaluation with Plant Cells of New Fosmidomycin Analogues Containing a Benzoxazolone or Oxazolopyridinone Ring, Journal of Enzyme Inhibition and Medicinal Chemistry, vol.18, issue.1975, pp.559-565, 2004.
DOI : 10.1080/14756360400004615

J. S. Jadhav, V. A. Chatpalliwar, S. C. Khadse, and R. R. Patil, Synthesis and screening of some new 2-(3H)-benzoxazolone derivatives for analgesic, antiinflammatory, and skeletal muscle relaxant activity, Indian J. Heterocycl. Chem, vol.17, pp.343-346, 2008.

M. Köksal, N. G. Kelekci, G. O. Mercanoglu, and H. Erdo?an, Synthesis and Evaluation of Analgesic, Anti-Inflammatory and Antioxidant Activities of New 6-Acyl-3-alkyl-5-methyl-2(3H) -benzoxazolones, Arzneimittelforschung, vol.58, issue.08, pp.398-404, 2008.
DOI : 10.1055/s-0031-1296527

C. Mésangeau, S. Narayanan, A. M. Green, J. Shaikh, N. Kaushal et al., Conversion of a Highly Selective Sigma-1 Receptor???Ligand to Sigma-2 Receptor Preferring Ligands with Anticocaine Activity, Journal of Medicinal Chemistry, vol.51, issue.5, pp.1482-1486, 2008.
DOI : 10.1021/jm701357m

J. H. Poupaert, P. Carato, and E. Colacino, 2(3H)-Benzoxazolone and Bioisosters as “Privileged Scaffold” in the Design of Pharmacological Probes, Current Medicinal Chemistry, vol.12, issue.7, pp.877-885, 2005.
DOI : 10.2174/0929867053507388

O. Diouf, P. Carato, P. Depreux, J. P. Bonte, D. H. Caignard et al., 5-HT1A and 5-HT2A ligands with anxiolytic and antipanic-like properties, Bioorganic & Medicinal Chemistry Letters, vol.7, issue.20, pp.2579-2584, 1997.
DOI : 10.1016/S0960-894X(97)10023-3

O. Diouf, P. Carato, I. Lesieur, M. C. Rettori, and D. H. Caignard, Synthesis and pharmacological evaluation of novel 4-(4-fluorobenzoyl)piperidine derivatives as mixed 5-HT1A/5-HT2A/D2 receptor ligands, European Journal of Medicinal Chemistry, vol.34, issue.1, pp.69-73, 1999.
DOI : 10.1016/S0223-5234(99)80042-7

P. Carato, D. Depreux, D. Lesieur, M. Millan, A. Newman-tancredi et al., Synthesis and binding studies on a new series of arylpiperazino benzazol-2-one and benzoxazin-3-one derivatives as selective D4 ligands, Drug Des. Discov, vol.17, pp.173-181, 2000.

N. Takechi, S. Ait-mohand, M. Medebielle, W. R. Dolbier, and . Jr, Nucleophilic trifluoromethylation of acyl chlorides using the trifluoromethyl iodide/TDAE reagent, Tetrahedron Letters, vol.43, issue.24, pp.4317-4319, 2002.
DOI : 10.1016/S0040-4039(02)00800-6

C. Pooput, M. Médebielle, W. F. Dolbier, and . Jr, A New and Efficient Method for the Synthesis of Trifluoromethylthio- and Selenoethers, Organic Letters, vol.6, issue.2, pp.301-303, 2004.
DOI : 10.1021/ol036303q

C. Pooput, W. F. Dolbier, . Jr, and M. Médebielle, Nucleophilic Perfluoroalkylation of Aldehydes, Ketones, Imines, Disulfides, and Diselenides, The Journal of Organic Chemistry, vol.71, issue.9, pp.3564-3568, 2006.
DOI : 10.1021/jo060250j

G. Giuglio-tonolo, T. Terme, M. Médebielle, and P. Vanelle, Original reaction of p-nitrobenzyl chloride with aldehydes using tetrakis(dimethylamino)ethylene (TDAE), Tetrahedron Letters, vol.44, issue.34, pp.6433-6435, 2003.
DOI : 10.1016/S0040-4039(03)01594-6

G. Giuglio-tonolo, T. Terme, M. Médebielle, and P. Vanelle, Nitrobenzylation of ??-carbonyl ester derivatives using TDAE approach, Tetrahedron Letters, vol.45, issue.26, pp.5121-5124, 2004.
DOI : 10.1016/j.tetlet.2004.04.166

O. Amiri-attou, T. Terme, and P. Vanelle, Functionalization of 6-Nitrobenzo[1,3]dioxole with Carbonyl Compounds via TDAE methodology, Molecules, vol.10, issue.3, pp.545-551, 2005.
DOI : 10.3390/10030545
URL : https://hal.archives-ouvertes.fr/hal-00014103

M. Montana, M. D. Crozet, C. Castera-ducros, T. Terme, and P. Vanelle, Rapid synthesis of new azaheterocyclic hydroxymalonate derivatives using TDAE approach, Heterocycles, vol.75, pp.925-932, 2008.

A. R. Nadji-boukrouche, O. Khoumeri, T. Terme, M. Liacha, and P. Vanelle, Original TDAE reactivity in benzoxa-and benzothiazolone series, ARKIVOC, vol.10, pp.358-370, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01460700

M. Montana, T. Terme, and P. Vanelle, Original synthesis of oxiranes via TDAE methodology: reaction of 2,2-dibromomethylquinoxaline with aromatic aldehydes, Tetrahedron Letters, vol.46, issue.48, pp.8373-8376, 2005.
DOI : 10.1016/j.tetlet.2005.09.152
URL : https://hal.archives-ouvertes.fr/hal-00014116

M. Montana, T. Terme, and P. Vanelle, Original synthesis of ??-chloroketones in azaheterocyclic series using TDAE approach, Tetrahedron Letters, vol.47, issue.37, pp.6573-6576, 2006.
DOI : 10.1016/j.tetlet.2006.07.030
URL : https://hal.archives-ouvertes.fr/hal-00096246

O. Khoumeri, M. Montana, T. Terme, and P. Vanelle, First TDAE approach in quinonic series: synthesis of new 2-substituted 1,4-dimethoxy-9,10-anthraquinones, Tetrahedron, vol.64, issue.49, pp.11237-11242, 2008.
DOI : 10.1016/j.tet.2008.09.046

P. Vanelle, J. Maldonado, N. Madadi, A. Gueiffier, J. Chapat et al., SRN1 reactions in imidazo[1,2-a]pyridine series, Tetrahedron Lett, pp.31-3013, 1990.

F. Delmas, M. Gasquet, P. Timon-david, N. Madadi, P. Vanelle et al., Synthesis and in vitro anti-protozoan activity of new 5-nitrothiophene oxime ether derivatives, European Journal of Medicinal Chemistry, vol.28, issue.1, pp.23-27, 1993.
DOI : 10.1016/0223-5234(93)90075-P

A. Gellis, P. Vanelle, M. Kaafarani, K. Benakli, and M. P. Crozet, Synth??se et r??actions SRN1 en s??rie 5-nitrothiazole, Tetrahedron, vol.53, issue.15, pp.5471-5484, 1997.
DOI : 10.1016/S0040-4020(97)00234-2

M. D. Crozet, C. Botta, M. Gasquet, C. Curti, V. Remusat et al., Lowering of 5-nitroimidazole's mutagenicity: Towards optimal antiparasitic pharmacophore, European Journal of Medicinal Chemistry, vol.44, issue.2, pp.653-659, 2009.
DOI : 10.1016/j.ejmech.2008.05.015

L. A. Dunn, A. G. Burgess, K. G. Krauer, L. Eckmann, P. Vanelle et al., A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro, International Journal of Antimicrobial Agents, vol.36, issue.1, pp.37-42, 2010.
DOI : 10.1016/j.ijantimicag.2010.03.004
URL : https://hal.archives-ouvertes.fr/hal-01460200

O. Khoumeri, M. D. Crozet, T. Terme, and P. Vanelle, Original TDAE application: synthesis of 2-substituted-4,11-dimethoxy-anthra[2,3-b]furan-5,10-diones via intramolecular Buchwald reaction, Tetrahedron Letters, vol.50, issue.46, pp.6372-6376, 2009.
DOI : 10.1016/j.tetlet.2009.08.096

F. Suzuki, S. Trenbeath, R. D. Gleim, and C. S. Sih, Total synthesis of anthracyclinones via intramolecular base-catalyzed cyclizations, The Journal of Organic Chemistry, vol.43, issue.21, pp.4159-4169, 1978.
DOI : 10.1021/jo00415a039

N. Gökhan, M. Köksal, E. Küpeli, E. Ye?ilada, and H. Erdo?an, Some new Mannich bases of 5-methyl-2-benzoxazolinones with analgesic and anti-inflammatory activities, Turk. J. Chem, vol.29, pp.445-454, 2005.

O. Amiri-attou and T. Terme, Original formation of benzyl benzoates by TDAE strategy, Tetrahedron Letters, vol.49, issue.6, pp.1016-1020, 2008.
DOI : 10.1016/j.tetlet.2007.12.011
URL : https://hal.archives-ouvertes.fr/hal-00267911

T. Juspin, M. Laget, T. Terme, N. Azas, and P. Vanelle, TDAE-assisted synthesis of new imidazo[2,1- b ]thiazole derivatives as anti-infectious agents, European Journal of Medicinal Chemistry, vol.45, issue.2, pp.840-845, 2010.
DOI : 10.1016/j.ejmech.2009.10.048
URL : https://hal.archives-ouvertes.fr/hal-01460233

M. Montana, F. Correard, O. Khoumeri, M. Esteve, T. Terme et al., Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines, Molecules, vol.19, issue.9, pp.14987-14998
DOI : 10.3390/molecules190914987
URL : https://hal.archives-ouvertes.fr/hal-01460539