Skip to Main content Skip to Navigation
Journal articles

Potential Therapeutical Contributions of the Endocannabinoid System towards Aging and Alzheimer's Disease

Abstract : Aging can lead to decline in cognition, notably due to neurodegenerative processes overwhelming the brain over time. As people live longer, numerous concerns are rightfully raised toward long-term slowly incapacitating diseases with no cure, such as Alzheimer's disease. Since the early 2000's, the role of neuroinflammation has been scrutinized for its potential role in the development of diverse neurodegenerative diseases notably because of its slow onset and chronic nature in aging. Despite the lack of success yet, treatment of chronic neuroinflammation could help alleviate process implicated in neurodegenerative disease. A growing number of studies including our own have aimed at the endocannabinoid system and unfolded unique effects of this system on neuroinflammation, neurogenesis and hallmarks of Alzheimer's disease and made it a reasonable target in the context of normal and pathological brain aging. Alzheimer's disease (AD) is the most common neurodegenerative disease and accounts for the majority of diagnosed dementia after age 60. It is estimated to currently affect between 20 and 30 million people worldwide with an incidence of the disease between 3 and 30% over the age of 60 [1]. As life expectancy increases, the prevalence of AD and its burden on healthcare is very likely to increase dramatically in the next few decades. Currently available drugs do not reverse or stop the progression of the disease, but only relieve certain cognitive symptoms and thus provide no cure for this growing health and economic concern. Alzheimer's disease
Document type :
Journal articles
Complete list of metadatas

Cited literature [74 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-01235539
Contributor : Administrateur Hal Amu <>
Submitted on : Monday, November 30, 2015 - 11:50:08 AM
Last modification on : Tuesday, March 17, 2020 - 3:26:53 AM
Long-term archiving on: : Tuesday, March 1, 2016 - 12:22:49 PM

File

ptpmcrendebnbr.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Amandine E. Bonnet, Yannick Marchalant. Potential Therapeutical Contributions of the Endocannabinoid System towards Aging and Alzheimer's Disease. Aging and disease, Kunlin Jin, 2015, 6, pp.400-405. ⟨10.14336/AD.2015.0617⟩. ⟨hal-01235539⟩

Share

Metrics

Record views

198

Files downloads

292