Synaptic Kainate Receptors in Interplay with INaP Shift the Sparse Firing of Dentate Granule Cells to a Sustained Rhythmic Mode in Temporal Lobe Epilepsy, Journal of Neuroscience, vol.31, issue.30, pp.10811-10818, 2011. ,
DOI : 10.1523/JNEUROSCI.0388-11.2011
ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo, Scientific Reports, vol.143, 2012. ,
DOI : 10.1038/srep00809
Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus, Epilepsia, vol.557, issue.Pt 6, 2011. ,
DOI : 10.1111/j.1528-1167.2011.03247.x
Imaging structural and functional brain networks in temporal lobe epilepsy, Frontiers in Human Neuroscience, vol.7, 2013. ,
DOI : 10.3389/fnhum.2013.00624
Brain injury impairs dentate gyrus inhibitory efficacy, Neurobiology of Disease, vol.25, issue.1, 2007. ,
DOI : 10.1016/j.nbd.2006.09.002
The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination, Glia, vol.382, issue.3, pp.441-456, 2012. ,
DOI : 10.1002/glia.22278
Development of epileptiform excitability in the deep entorhinal cortex after status epilepticus, European Journal of Neuroscience, vol.59, issue.Suppl 6, pp.611-624, 2009. ,
DOI : 10.1111/j.1460-9568.2009.06863.x
Mossy fiber sprouting in the dentate gyrus, Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th Edn, 2012. ,
Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit, J. Neurosci, vol.22, pp.6650-6658, 2002. ,
Reactive Gliosis and the Multicellular Response to CNS Damage and Disease, Neuron, vol.81, issue.2, 2014. ,
DOI : 10.1016/j.neuron.2013.12.034
Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice, Neuron, vol.23, issue.2, pp.297-308, 1999. ,
DOI : 10.1016/S0896-6273(00)80781-3
ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia., Behavioral Neuroscience, vol.125, issue.3, pp.465-472, 1037. ,
DOI : 10.1037/a0023167
Long-Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures, Epilepsia, vol.4, issue.6, pp.778-782, 1991. ,
DOI : 10.1002/syn.890030207
ROCK inhibition with Y27632 activates astrocytes and increases their expression of neurite growth-inhibitory chondroitin sulfate proteoglycans, Glia, vol.18, issue.4, pp.369-384, 2007. ,
DOI : 10.1002/glia.20466
Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies, Trends in Neurosciences, vol.28, issue.2, pp.108-115, 2005. ,
DOI : 10.1016/j.tins.2004.11.011
URL : https://hal.archives-ouvertes.fr/inserm-00484541
The pilocarpine model of temporal lobe epilepsy, Journal of Neuroscience Methods, vol.172, issue.2, pp.143-157, 2008. ,
DOI : 10.1016/j.jneumeth.2008.04.019
Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy, Experimental Neurology, vol.269, pp.102-119, 2015. ,
DOI : 10.1016/j.expneurol.2015.04.003
Specificity and mechanism of action of some commonly used protein kinase inhibitors, Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th Edn: National Center for Biotechnology Information), pp.95-105, 2000. ,
DOI : 10.1042/bj3510095
Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice, Journal of Neurochemistry, vol.115, issue.6, pp.1619-1629, 2010. ,
DOI : 10.1111/j.1471-4159.2010.06876.x
Activation of Rho after traumatic brain injury and seizure in rats, Experimental Neurology, vol.198, issue.2, pp.361-369, 2006. ,
DOI : 10.1016/j.expneurol.2005.12.002
Epileptogenesis in the dentate gyrus: a critical perspective, Prog. Brain Res, vol.163, issue.07, pp.755-773, 2007. ,
DOI : 10.1016/S0079-6123(07)63041-6
Testosterone and its metabolites affect afterdischarge thresholds and the development of amygdala kindled seizures, Brain Research, vol.838, issue.1-2, pp.151-157, 1999. ,
DOI : 10.1016/S0006-8993(99)01620-0
Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy, JAMA, vol.307, issue.9, pp.922-930, 2012. ,
DOI : 10.1001/jama.2012.220
Recurrent Mossy Fibers Establish Aberrant Kainate Receptor-Operated Synapses on Granule Cells from Epileptic Rats, Journal of Neuroscience, vol.25, issue.36, pp.8229-8239, 2005. ,
DOI : 10.1523/JNEUROSCI.1469-05.2005
URL : https://hal.archives-ouvertes.fr/inserm-00484549
Newly formed excitatory pathways provide a substrate for hyperexcitability in experimental temporal lobe epilepsy4<449::aid-cne1>3.0.co Rho kinase inhibition enhances axonal regeneration in the injured CNS, J. Comp. Neurol. J. Neurosci, vol.4084082, issue.23, pp.449-460, 1999. ,
Axon growth inhibition by RhoA/ROCK in the central nervous system, Frontiers in Neuroscience, vol.302, issue.39, 2014. ,
DOI : 10.1126/science.1090154
Stimulus and Potassium-Induced Epileptiform Activity in the Human Dentate Gyrus from Patients with and without Hippocampal Sclerosis, Journal of Neuroscience, vol.24, issue.46, pp.10416-10430, 2004. ,
DOI : 10.1523/JNEUROSCI.2074-04.2004
Sexually dimorphic expression of KCC2 and GABA function, Epilepsy Research, vol.80, issue.2-3, pp.99-113, 2008. ,
DOI : 10.1016/j.eplepsyres.2008.04.013
Estradiol reduces seizure-induced hippocampal injury in ovariectomized female but not in male rats, Neuroscience Letters, vol.342, issue.3, pp.201-205, 2003. ,
DOI : 10.1016/S0304-3940(03)00282-9
Role of sex hormones in the sexually dimorphic expression of KCC2 in rat substantia nigra, Experimental Neurology, vol.184, issue.2, pp.1003-1009, 2003. ,
DOI : 10.1016/S0014-4886(03)00387-X
Sex dimorphism in seizure-controlling networks, Neurobiology of Disease, vol.72, 2014. ,
DOI : 10.1016/j.nbd.2014.05.010
Rho kinase inhibition protects CA1 cells in organotypic hippocampal slices during in vitro ischemia, Brain Research, vol.1316, 2010. ,
DOI : 10.1016/j.brainres.2009.11.087
Astrocyte-neuronal interactions in epileptogenesis, Journal of Neuroscience Research, vol.47, issue.Suppl 2, pp.1157-1164, 2015. ,
DOI : 10.1016/j.expneurol.2011.08.024
Hippocampal granule cell activity and c-Fos expression during spontaneous seizures in awake, chronically epileptic, pilocarpine-treated rats: Implications for hippocampal epileptogenesis, The Journal of Comparative Neurology, vol.24, issue.4, pp.442-463, 2005. ,
DOI : 10.1002/cne.20594
Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders, Frontiers in Neuroscience, vol.302, issue.239, 2015. ,
DOI : 10.1126/science.1090154
Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy, Brain Research, vol.535, issue.2, pp.195-204, 1990. ,
DOI : 10.1016/0006-8993(90)91601-C
Perturbed Chloride Homeostasis and GABAergic Signaling in Human Temporal Lobe Epilepsy, Journal of Neuroscience, vol.27, issue.37, pp.9866-9873, 2007. ,
DOI : 10.1523/JNEUROSCI.2761-07.2007
URL : https://hal.archives-ouvertes.fr/inserm-00173026
Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice, British Journal of Pharmacology, vol.94, issue.1, pp.44-51225, 2008. ,
DOI : 10.1038/bjp.2008.225
Downregulation of Potassium Chloride Cotransporter KCC2 After Transient Focal Cerebral Ischemia, Stroke, vol.41, issue.3, 2010. ,
DOI : 10.1161/STROKEAHA.109.570424
Advances in understanding basic mechanisms of epilepsy and seizures, Seizure, vol.19, issue.10, pp.638-646, 2010. ,
DOI : 10.1016/j.seizure.2010.10.026
ROCK) inhibitor Y-27632 protects against excitotoxicityinduced neuronal death in vivo and in vitro, Neurotox. Res, vol.23, pp.238-248 ,
Hilar Mossy Cell Degeneration Causes Transient Dentate Granule Cell Hyperexcitability and Impaired Pattern Separation, Neuron, vol.76, issue.6, pp.1189-1200, 2012. ,
DOI : 10.1016/j.neuron.2012.10.036
URL : http://doi.org/10.1016/j.neuron.2012.10.036
Astrocyte-mediated metaplasticity in the hippocampus: Help or hindrance?, Neuroscience, vol.309, p.35, 2015. ,
DOI : 10.1016/j.neuroscience.2015.08.035
Inhibition of Rho-kinase differentially affects axon regeneration of peripheral motor and sensory nerves, Experimental Neurology, vol.263, pp.28-38, 2015. ,
DOI : 10.1016/j.expneurol.2014.09.012
Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy, EMBO reports, vol.15, issue.7, pp.766-774, 2014. ,
DOI : 10.15252/embr.201438840
The therapeutic effects of Rho-ROCK inhibitors on CNS disorders, Therapeutics and Clinical Risk Management, vol.4, pp.605-615, 2008. ,
DOI : 10.2147/TCRM.S2907
The Rho kinase inhibitor fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor?mediated currents, Br. J. Pharmacol. Nat. Neurosci, vol.163, issue.14, pp.533-545, 2011. ,
The Global Burden of Epilepsy, Epilepsia, vol.42, 2002. ,
DOI : 10.1046/j.1528-1157.43.s.6.11.x
KCC2 regulates actin dynamics in dendritic spines via interaction with ??-PIX, The Journal of Cell Biology, vol.279, issue.5, pp.671-686, 2015. ,
DOI : 10.1523/JNEUROSCI.3553-04.2005
The Role of Astroglia in the Epileptic Brain, Frontiers in Pharmacology, vol.3, 2012. ,
DOI : 10.3389/fphar.2012.00132
Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission, European Journal of Neuroscience, vol.444, issue.12, pp.3199-3206, 2003. ,
DOI : 10.1074/jbc.274.18.12656
Neurosteroid Synthesis-Mediated Regulation of GABAA Receptors: Relevance to the Ovarian Cycle and Stress, Journal of Neuroscience, vol.27, issue.9, pp.2155-2162, 2007. ,
DOI : 10.1523/JNEUROSCI.4945-06.2007
Ovarian cycle???linked changes in GABAA receptors mediating tonic inhibition alter seizure susceptibility and anxiety, Nature Neuroscience, vol.44, issue.6, pp.797-804, 1038. ,
DOI : 10.1016/S0006-3223(02)01924-8
Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy, Neurology, vol.52, issue.3, pp.453-472, 1999. ,
DOI : 10.1212/WNL.52.3.453
Cellular and molecular basis of epilepsy, J. Neurosci, vol.14, pp.3413-3425, 1994. ,
Current view on the functional regulation of the neuronal K+-Cl??? cotransporter KCC2, Frontiers in Cellular Neuroscience, vol.8, p.27, 2014. ,
DOI : 10.3389/fncel.2014.00027
Sex differences in models of temporal lobe epilepsy: role of testosterone, Brain Research, vol.944, issue.1-2, pp.210-218, 2002. ,
DOI : 10.1016/S0006-8993(02)02691-4
Kindling and status epilepticus models of epilepsy: rewiring the brain, Progress in Neurobiology, vol.73, issue.1, 2004. ,
DOI : 10.1016/j.pneurobio.2004.03.009
The recurrent mossy fiber pathway of the epileptic brain, Neurochemical Research, vol.28, issue.11, pp.1649-1658, 2003. ,
DOI : 10.1023/A:1026004904199
Estrogen and Ovariectomy Regulate mRNA and Protein of Glutamic Acid Decarboxylases and Cation-Chloride Cotransporters in the Adult Rat Hippocampus, Neuroendocrinology, vol.80, issue.5, pp.308-323, 1159. ,
DOI : 10.1159/000083657
Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice, Physiology & Behavior, vol.143, pp.142-150, 2015. ,
DOI : 10.1016/j.physbeh.2015.03.004
Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis, Front. Neurosci, 2015. ,
Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory, Proceedings of the National Academy of Sciences, vol.103, issue.22, pp.8465-8468, 2006. ,
DOI : 10.1073/pnas.0602979103
Disrupted Dentate Granule Cell Chloride Regulation Enhances Synaptic Excitability during Development of Temporal Lobe Epilepsy, Journal of Neuroscience, vol.27, issue.51, pp.14012-140224390, 2007. ,
DOI : 10.1523/JNEUROSCI.4390-07.2007
Microcircuits and their interactions in epilepsy: is the focus out of focus?, Nature Neuroscience, vol.71, issue.3, pp.351-359, 2015. ,
DOI : 10.1523/JNEUROSCI.0753-07.2007
Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival, The Journal of Physiology, vol.21, issue.10, pp.2475-2496, 2011. ,
DOI : 10.1113/jphysiol.2010.203703
Contribution of Aberrant GluK2-Containing Kainate Receptors to Chronic Seizures in Temporal Lobe Epilepsy, Cell Reports, vol.8, issue.2, pp.347-354, 2014. ,
DOI : 10.1016/j.celrep.2014.06.032
Sex Differences in the Chloride Cotransporters, NKCC1 and KCC2, in the Developing Hypothalamus, Journal of Neuroendocrinology, vol.557, issue.4, pp.302-308, 2007. ,
DOI : 10.1016/S0960-0760(02)00119-X
Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine, Physiology & Behavior, vol.44, issue.1, pp.27-37, 1988. ,
DOI : 10.1016/0031-9384(88)90342-3
A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation, EMBO reports, vol.15, pp.723-729, 2014. ,
DOI : 10.1002/embr.201438749
Modification of seizure activity by electrical stimulation: II. Motor seizure, Electroencephalography and Clinical Neurophysiology, vol.32, issue.3, pp.281-294, 1972. ,
DOI : 10.1016/0013-4694(72)90177-0
Hippocampal plasticity in the kindling model of epilepsy in rats, Neuroscience Letters, vol.99, issue.3, pp.345-350, 1989. ,
DOI : 10.1016/0304-3940(89)90471-0
Pro-Brain-Derived Neurotrophic Factor Inhibits GABAergic Neurotransmission by Activating Endocytosis and Repression of GABAA Receptors, Journal of Neuroscience, vol.34, issue.40, pp.13516-13534, 2014. ,
DOI : 10.1523/JNEUROSCI.2069-14.2014
Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease, Neurobiology of Disease, vol.58, pp.209-219, 2013. ,
DOI : 10.1016/j.nbd.2013.06.004
Gabapentin Administration Reduces Reactive Gliosis and Neurodegeneration after Pilocarpine-Induced Status Epilepticus, PLoS ONE, vol.135, issue.1, 2013. ,
DOI : 10.1371/journal.pone.0078516.g008
Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine, Experimental Neurology, vol.196, issue.1, pp.73-86, 2005. ,
DOI : 10.1016/j.expneurol.2005.07.007
The Influence of Gonadal Hormones on Neuronal Excitability, Seizures, and Epilepsy in the Female, Epilepsia, vol.96, issue.9, 2006. ,
DOI : 10.1016/S0091-3057(00)00375-0
Sex differences in the neurobiology of epilepsy: A preclinical perspective, Neurobiology of Disease, vol.72, 2014. ,
DOI : 10.1016/j.nbd.2014.07.004
Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration, Brain Research, vol.874, issue.2, pp.123-130, 2000. ,
DOI : 10.1016/S0006-8993(00)02513-0
Repair of the Injured Adult Hippocampus through Graft-Mediated Modulation of the Plasticity of the Dentate Gyrus in a Rat Model of Temporal Lobe Epilepsy, Journal of Neuroscience, vol.25, issue.37, pp.8391-8401, 2005. ,
DOI : 10.1523/JNEUROSCI.1538-05.2005
Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy, European Journal of Neuroscience, vol.29, issue.Suppl. 3, pp.974-986, 2015. ,
DOI : 10.1111/ejn.12835
The Loop Diuretic Bumetanide Blocks Posttraumatic p75NTR Upregulation and Rescues Injured Neurons, Journal of Neuroscience, vol.32, issue.5, pp.1757-1770, 2012. ,
DOI : 10.1523/JNEUROSCI.3282-11.2012
Posttraumatic GABAA-Mediated [Ca2+]i Increase Is Essential for the Induction of Brain-Derived Neurotrophic Factor-Dependent Survival of Mature Central Neurons, Journal of Neuroscience, vol.28, issue.27, pp.6996-70055268, 2008. ,
DOI : 10.1523/JNEUROSCI.5268-07.2008
Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy, Science, vol.235, issue.4784, pp.73-76, 1987. ,
DOI : 10.1126/science.2879352
Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: The importance of the ???latent period??? and other concepts, Epilepsia, vol.24, issue.9 Suppl. 5, pp.85-92, 2002. ,
DOI : 10.1111/j.1528-1167.2008.01931.x
Intractable seizures in pregnancy, The Lancet, vol.354, issue.9189, pp.1522-1532, 1999. ,
DOI : 10.1016/S0140-6736(99)09164-3
Reactive Astrocytes in Neural Repair and Protection, The Neuroscientist, vol.44, issue.5, pp.400-407, 2005. ,
DOI : 10.1523/JNEUROSCI.3547-03.2004
Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures, Nature Communications, vol.15, 2015. ,
DOI : 10.1152/ajpcell.00274.2012
Mossy fiber synaptic reorganization in the epileptic human temporal lobe, Annals of Neurology, vol.14, issue.3, pp.321-330, 1989. ,
DOI : 10.1002/ana.410260303
Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats, J. Neurosci, vol.5, pp.1016-1022, 1985. ,
Early Activation of Ventral Hippocampus and Subiculum during Spontaneous Seizures in a Rat Model of Temporal Lobe Epilepsy, Journal of Neuroscience, vol.33, issue.27, pp.11100-11115, 2013. ,
DOI : 10.1523/JNEUROSCI.0472-13.2013
Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study, Behavioural Brain Research, vol.9, issue.3, pp.315-335, 1983. ,
DOI : 10.1016/0166-4328(83)90136-5
Castration in female rats modifies the development of the pilocarpine model of epilepsy, Epilepsy Research, vol.49, issue.3, pp.181-188, 2002. ,
DOI : 10.1016/S0920-1211(02)00024-4
Stereologic estimation of hippocampal GluR2/3-and calretininimmunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain, Epilepsia Cell Death Dis, vol.52, pp.1579-1589, 2011. ,
Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons, Brain Research, vol.1154, pp.215-224, 2007. ,
DOI : 10.1016/j.brainres.2007.04.013
Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic A??42 by Inhibiting Rho, Science, vol.302, issue.5648, pp.1215-1217, 2003. ,
DOI : 10.1126/science.1090154