Prevalence of Mycobacterium lentiflavum in cystic fibrosis patients, France

Michael Phelippeau (1) , Jean-Christophe Dubus (2) , Martine Reynaud-Gaubert (1, 3) , Carine Gomez (1, 3) , Nathalie Stremler Le Bel (2) , Marielle Bedotto (1) , Elsa Prudent (1) , Michel Drancourt (1)

1 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
2 Centre de Ressource et de Compétences de la Mucoviscidose (CRCM) pédiatrique
3 Centre de Ressource et de Compétences de la Mucoviscidose (CRCM) adulte

Background: Mycobacterium lentiflavum is rarely isolated in respiratory tract samples from cystic fibrosis patients. We herein describe an unusually high prevalence of M. lentiflavum in such patients. Methods: M. lentiflavum, isolated from the respiratory tract of cystic fibrosis patients, was identified using both rpoB partial sequencing and detected directly in the sputum by using real-time PCR targeting the smpB gene. Results: M. lentiflavum emerged as the third most prevalent nontuberculous mycobacterial species isolated in cystic fibrosis patients in Marseille, France. Six such patients were all male, and two of them may have fulfilled the American Thoracic Society clinical and microbiological criteria for M. lentiflavum potential lung infection. Conclusions: M. lentiflavum was the third most common mycobacteria isolated in cystic fibrosis patients, particularly in six male patients. M. lentiflavum outbreaks are emerging particularly in cystic fibrosis patients.

Mots clés: Mycobacterium lentiflavum; Cystic fibrosis; rpoB; smpB

Domaines: Médecine humaine et pathologie

Michael Phelippeau, Jean-Christophe Dubus, Martine Reynaud-Gaubert, Carine Gomez, Nathalie Stremler Le Bel, et al.. Prevalence of Mycobacterium lentiflavum in cystic fibrosis patients, France. BMC Pulmonary Medicine, 2015, 15 (131), ⟨10.1186/s12890-015-0123-y⟩. ⟨hal-01236255⟩