T. Stanton, A call for antibiotic alternatives research, Trends in Microbiology, vol.21, issue.3, pp.111-113, 2013.
DOI : 10.1016/j.tim.2012.11.002

M. Garcia-quintanilla, M. Pulido, R. Lopez-rojas, J. Pachon, and M. Mcconnell, Emerging therapies for multidrug resistant Acinetobacter baumannii, Trends in Microbiology, vol.21, issue.3, pp.157-163, 2013.
DOI : 10.1016/j.tim.2012.12.002

E. Breidenstein, C. Fuente-nunez, and R. Hancock, Pseudomonas aeruginosa: all roads lead to resistance, Trends in Microbiology, vol.19, issue.8, pp.419-426, 2011.
DOI : 10.1016/j.tim.2011.04.005

A. Agodi, M. Barchitta, R. Cipresso, L. Giaquinta, and M. Romeo, Pseudomonas aeruginosa carriage, colonization, and infection in ICU patients, Intensive Care Medicine, vol.65, issue.Suppl 4, pp.1155-1161, 2007.
DOI : 10.1007/s00134-007-0671-6

C. Adair, S. Gorman, B. Feron, L. Byers, and D. Jones, Implications of endotracheal tube biofilm for ventilator-associated pneumonia, Intensive Care Medicine, vol.25, issue.10, pp.1072-1076, 1999.
DOI : 10.1007/s001340051014

N. Hoiby, T. Bjarnsholt, M. Givskov, S. Molin, and O. Ciofu, Antibiotic resistance of bacterial biofilms, International Journal of Antimicrobial Agents, vol.35, issue.4, pp.322-332, 2010.
DOI : 10.1016/j.ijantimicag.2009.12.011

URL : https://hal.archives-ouvertes.fr/hal-00567285

M. Schuster, D. Sexton, S. Diggle, and E. Greenberg, Acyl-Homoserine Lactone Quorum Sensing: From Evolution to Application, Annual Review of Microbiology, vol.67, issue.1, 2013.
DOI : 10.1146/annurev-micro-092412-155635

V. Wagner, J. Frelinger, R. Barth, and B. Iglewski, Quorum sensing: dynamic response of Pseudomonas aeruginosa to external signals, Trends in Microbiology, vol.14, issue.2, pp.55-58, 2006.
DOI : 10.1016/j.tim.2005.12.002

P. Lesprit, F. Faurisson, O. Join-lambert, F. Roudot-thoraval, and M. Foglino, in Rats, American Journal of Respiratory and Critical Care Medicine, vol.167, issue.11, pp.1478-1482, 2003.
DOI : 10.1164/rccm.200207-736BC

M. Grabiner, Z. Fu, T. Wu, K. Barry, and C. Schwarzer, Pseudomonas aeruginosa Quorum-Sensing Molecule Homoserine Lactone Modulates Inflammatory Signaling through PERK and eI-F2alpha, J Immunol. jimmunol, vol.10, p.130343740491303437, 2014.

M. Parsek and E. Greenberg, Sociomicrobiology: the connections between quorum sensing and biofilms, Trends in Microbiology, vol.13, issue.1, pp.27-33, 2005.
DOI : 10.1016/j.tim.2004.11.007

J. Costerton, P. Stewart, and E. Greenberg, Bacterial Biofilms: A Common Cause of Persistent Infections, Science, vol.284, issue.5418, pp.1318-1322, 1999.
DOI : 10.1126/science.284.5418.1318

P. Williams and M. Camara, Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules, Current Opinion in Microbiology, vol.12, issue.2, pp.182-191, 2009.
DOI : 10.1016/j.mib.2009.01.005

W. Galloway, J. Hodgkinson, S. Bowden, M. Welch, and D. Spring, Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria, Trends in Microbiology, vol.20, issue.9, pp.449-458, 2012.
DOI : 10.1016/j.tim.2012.06.003

V. Kalia, Quorum sensing inhibitors: An overview, Biotechnology Advances, vol.31, issue.2, pp.224-245, 2013.
DOI : 10.1016/j.biotechadv.2012.10.004

T. Rasmussen and M. Givskov, Quorum-sensing inhibitors as anti-pathogenic drugs, International Journal of Medical Microbiology, vol.296, issue.2-3, pp.149-161, 2006.
DOI : 10.1016/j.ijmm.2006.02.005

Y. Dong, L. Wang, J. Xu, H. Zhang, and X. Zhang, Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase, Nature, vol.411, issue.6839, pp.813-817, 2001.
DOI : 10.1038/35081101

N. Amara, B. Krom, G. Kaufmann, and M. Meijler, Macromolecular Inhibition of Quorum Sensing: Enzymes, Antibodies, and Beyond, Chemical Reviews, vol.111, issue.1, pp.195-208, 2011.
DOI : 10.1021/cr100101c

M. Hentzer, H. Wu, J. Andersen, K. Riedel, and T. Rasmussen, Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors, The EMBO Journal, vol.22, issue.15, pp.3803-3815, 2003.
DOI : 10.1093/emboj/cdg366

T. Rasmussen, M. Skindersoe, T. Bjarnsholt, R. Phipps, and K. Christensen, Identity and effects of quorum-sensing inhibitors produced by Penicillium species, Microbiology, vol.151, issue.5, pp.1325-1340, 2005.
DOI : 10.1099/mic.0.27715-0

T. Jakobsen, G. Van, R. Phipps, M. Shanmugham, and L. Christensen, Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing, Antimicrobial Agents and Chemotherapy, vol.56, issue.5, pp.2314-232505919, 1128.
DOI : 10.1128/AAC.05919-11

C. O9loughlin, L. Miller, A. Siryaporn, K. Drescher, and M. Semmelhack, A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation, Proceedings of the National Academy of Sciences, vol.110, issue.44, pp.17981-17986, 1073.
DOI : 10.1073/pnas.1316981110

J. Baveja, M. Willcox, E. Hume, N. Kumar, and R. Odell, Furanones as potential anti-bacterial coatings on biomaterials, Biomaterials, vol.25, issue.20, pp.5003-5012, 2004.
DOI : 10.1016/j.biomaterials.2004.02.051

T. Bjarnsholt, T. Tolker-nielsen, N. Hoiby, and M. Givskov, Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control, Expert Reviews in Molecular Medicine, vol.148, 2010.
DOI : 10.1128/AEM.69.4.2313-2320.2003

S. Uroz, P. Oger, E. Chapelle, M. Adeline, and D. Faure, A Rhodococcus qsdA-Encoded Enzyme Defines a Novel Class of Large-Spectrum Quorum-Quenching Lactonases, Applied and Environmental Microbiology, vol.74, issue.5, pp.1357-1366, 2008.
DOI : 10.1128/AEM.02014-07

URL : https://hal.archives-ouvertes.fr/hal-00342712

F. Ng, D. Wright, and S. Seah, Characterization of a Phosphotriesterase-Like Lactonase from Sulfolobus solfataricus and Its Immobilization for Disruption of Quorum Sensing, Applied and Environmental Microbiology, vol.77, issue.4, pp.1181-1186, 2011.
DOI : 10.1128/AEM.01642-10

R. Pei and G. Lamas-samanamud, Inhibition of Biofilm Formation by T7 Bacteriophages Producing Quorum-Quenching Enzymes, Applied and Environmental Microbiology, vol.80, issue.17, pp.1434-1401434, 1128.
DOI : 10.1128/AEM.01434-14

Y. Dong, J. Xu, X. Li, and L. Zhang, AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora, Proceedings of the National Academy of Sciences, vol.97, issue.7, pp.3526-3531, 2000.
DOI : 10.1073/pnas.97.7.3526

D. Stoltz, E. Ozer, P. Taft, M. Barry, and L. Liu, Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1, Journal of Clinical Investigation, vol.118, issue.9, pp.3123-3131, 2008.
DOI : 10.1172/JCI35147DS1

E. Papaioannou, M. Wahjudi, P. Nadal-jimenez, G. Koch, and R. Setroikromo, Quorum-Quenching Acylase Reduces the Virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans Infection Model, Antimicrobial Agents and Chemotherapy, vol.53, issue.11, pp.4891-489700380, 1128.
DOI : 10.1128/AAC.00380-09

Y. Migiyama, Y. Kaneko, K. Yanagihara, T. Morohoshi, and Y. Morinaga, Efficacy of AiiM, an N-Acylhomoserine Lactonase, against Pseudomonas aeruginosa in a Mouse Model of Acute Pneumonia, Antimicrobial Agents and Chemotherapy, vol.57, issue.8, pp.3653-3658, 2013.
DOI : 10.1128/AAC.00456-13

J. Hiblot, G. Gotthard, M. Elias, and E. Chabriere, Differential Active Site Loop Conformations Mediate Promiscuous Activities in the Lactonase SsoPox, PLoS ONE, vol.18, issue.9, 2013.
DOI : 10.1371/journal.pone.0075272.s010

F. Studier, Protein production by auto-induction in high-density shaking cultures, Protein Expression and Purification, vol.41, issue.1, pp.207-234, 2005.
DOI : 10.1016/j.pep.2005.01.016

J. Hiblot, G. Gotthard, E. Chabriere, and M. Elias, Characterisation of the organophosphate hydrolase catalytic activity of SsoPox, Scientific Reports, vol.66, 2012.
DOI : 10.1038/srep00779

M. Wilkins, E. Gasteiger, A. Bairoch, J. Sanchez, and K. Williams, Protein Identification and Analysis Tools in the ExPASy Server, Methods Mol Biol, vol.112, pp.531-552, 1999.
DOI : 10.1385/1-59259-584-7:531

S. Hraiech, A. Roch, H. Lepidi, T. Atieh, and G. Audoly, Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia, Antimicrobial Agents and Chemotherapy, vol.57, issue.10, pp.5120-5121, 2013.
DOI : 10.1128/AAC.00700-13

A. Price-whelan, L. Dietrich, and D. Newman, Pyocyanin Alters Redox Homeostasis and Carbon Flux through Central Metabolic Pathways in Pseudomonas aeruginosa PA14, Journal of Bacteriology, vol.189, issue.17, pp.6372-638100505, 1128.
DOI : 10.1128/JB.00505-07

M. Nicodeme, J. Grill, G. Humbert, and J. Gaillard, Extracellular protease activity of different Pseudomonas strains: dependence of proteolytic activity on culture conditions, Journal of Applied Microbiology, vol.717, issue.3, pp.641-648, 2005.
DOI : 10.1016/S0958-6946(97)00008-3

C. Marquette, D. Wermert, F. Wallet, M. Copin, and A. Tonnel, Characterization of an Animal Model of Ventilator-Acquired Pneumonia, Chest, vol.115, issue.1, pp.200-209, 1999.
DOI : 10.1378/chest.115.1.200

S. Hraiech, F. Bregeon, J. Brunel, J. Rolain, and H. Lepidi, Antibacterial efficacy of inhaled squalamine in a rat model of chronic Pseudomonas aeruginosa pneumonia, Journal of Antimicrobial Chemotherapy, vol.67, issue.10, pp.2452-2458, 1093.
DOI : 10.1093/jac/dks230

V. Wagner, R. Gillis, and B. Iglewski, Transcriptome analysis of quorumsensing regulation and virulence factor expression in Pseudomonas aeruginosa, Vaccine, vol.2210, issue.1, pp.15-20, 2004.

J. Dickschat, Quorum sensing and bacterial biofilms, Natural Product Reports, vol.74, issue.3, pp.343-369, 1039.
DOI : 10.1039/b804469b

E. Deziel, S. Gopalan, A. Tampakaki, F. Lepine, and K. Padfield, The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl- l-homoserine lactones, Molecular Microbiology, vol.273, issue.Suppl. 1, pp.998-1014, 2005.
DOI : 10.1111/j.1365-2958.2004.04448.x

A. Ilangovan, M. Fletcher, G. Rampioni, C. Pustelny, and K. Rumbaugh, Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR), PLoS Pathogens, vol.76, issue.7, 2013.
DOI : 10.1371/journal.ppat.1003508.s006

I. Bakker-woudenberg, M. Ten-kate, L. Guo, P. Working, and J. Mouton, Ciprofloxacin in Polyethylene Glycol-Coated Liposomes: Efficacy in Rat Models of Acute or Chronic Pseudomonas aeruginosa Infection, Antimicrobial Agents and Chemotherapy, vol.46, issue.8, pp.2575-2581, 2002.
DOI : 10.1128/AAC.46.8.2575-2581.2002

S. Rezaiguia, C. Garat, C. Delclaux, M. Meignan, and J. Fleury, Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism., Journal of Clinical Investigation, vol.99, issue.2, pp.325-335, 1997.
DOI : 10.1172/JCI119161

J. Wen, C. Li, L. Gu, S. Yin, and W. Li, Aging Reduces the Expression of Lung CINC and MCP-1 mRNA in a P. aeruginosa Rat Model of Infection, Inflammation, vol.120, issue.12, pp.933-941, 2014.
DOI : 10.1007/s10753-014-9813-5

J. Pearson, M. Feldman, B. Iglewski, and A. Prince, Pseudomonas aeruginosa Cell-to-Cell Signaling Is Required for Virulence in a Model of Acute Pulmonary Infection, Infection and Immunity, vol.68, issue.7, pp.4331-4334, 2000.
DOI : 10.1128/IAI.68.7.4331-4334.2000

R. Smith, S. Harris, R. Phipps, and B. Iglewski, The Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3-Oxododecanoyl)Homoserine Lactone Contributes to Virulence and Induces Inflammation In Vivo, Journal of Bacteriology, vol.184, issue.4, pp.1132-1139, 2002.
DOI : 10.1128/jb.184.4.1132-1139.2002

P. Seed, L. Passador, and B. Iglewski, Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: an autoinduction regulatory hierarchy., Journal of Bacteriology, vol.177, issue.3, pp.654-659, 1995.
DOI : 10.1128/jb.177.3.654-659.1995

S. Rutherford and B. Bassler, Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med 2, 2012.

L. Christensen, G. Van, T. Jakobsen, M. Alhede, and H. Hougen, Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model, Journal of Antimicrobial Chemotherapy, vol.67, issue.5, pp.1198-1206, 1093.
DOI : 10.1093/jac/dks002

D. Van, T. Kohler, F. Brunner-ferber, B. Francois, and J. Carlet, Azithromycin to prevent Pseudomonas aeruginosa ventilator-associated pneumonia by inhibition of quorum sensing: a randomized controlled trial, Intensive Care Med, vol.38, pp.1118-1125, 2012.