J. A. Den-boon, A. Diaz, and P. Ahlquist, Cytoplasmic Viral Replication Complexes, Cell Host & Microbe, vol.8, issue.1, pp.77-85, 2010.
DOI : 10.1016/j.chom.2010.06.010

R. W. Ruigrok, T. Crépin, and D. Kolakofsky, Nucleoproteins and nucleocapsids of negative-strand RNA viruses, Current Opinion in Microbiology, vol.14, issue.4, pp.504-510, 2011.
DOI : 10.1016/j.mib.2011.07.011

P. Wang, Y. Wang, Y. Zhao, Z. Zhu, J. Yu et al., Classical swine fever virus NS3 enhances RNA-dependent RNA polymerase activity by binding to NS5B, Virus Research, vol.148, issue.1-2, pp.17-23, 2010.
DOI : 10.1016/j.virusres.2009.11.015

P. J. Kranzusch and S. P. Whelan, Architecture and regulation of negative-strand viral enzymatic machinery, RNA Biology, vol.83, issue.7, pp.941-948, 2012.
DOI : 10.1099/vir.0.83582-0

A. A. Rahmeh, B. Morin, A. D. Schenk, B. Liang, B. S. Heinrich et al., Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus, Proceedings of the National Academy of Sciences, vol.109, issue.36, pp.14628-14633, 2012.
DOI : 10.1073/pnas.1209147109

H. Takahashi, C. Takahashi, N. J. Moreland, Y. Chang, T. Sawasaki et al., Establishment of a robust dengue virus NS3???NS5 binding assay for identification of protein???protein interaction inhibitors, Antiviral Research, vol.96, issue.3, pp.305-314, 2012.
DOI : 10.1016/j.antiviral.2012.09.023

B. D. Lindenbach and C. M. Rice, Flaviviridae: the viruses and their replication, pp.1101-1151, 2007.

D. J. Gubler, Dengue, Urbanization and Globalization: The Unholy Trinity of the 21st Century, Tropical Medicine and Health, vol.14, issue.1, pp.3-11, 2011.
DOI : 10.1038/nrmicro1690

S. Bhatt, P. W. Gething, O. J. Brady, J. P. Messina, A. W. Farlow et al., The global distribution and burden of dengue, Nature, vol.62, issue.7446, pp.504-507, 2013.
DOI : 10.1038/nature12060

D. Normile, Tropical medicine. Surprising new dengue virus throws a spanner in disease control efforts, Science, pp.342-415, 2013.

S. Welsch, S. Miller, I. Romero-brey, A. Merz, C. K. Bleck et al., Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites, Cell Host & Microbe, vol.5, issue.4, pp.365-375, 2009.
DOI : 10.1016/j.chom.2009.03.007

G. Lu and P. Gong, Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface, PLoS Pathogens, vol.54, issue.8, p.1003549, 2013.
DOI : 10.1371/journal.ppat.1003549.s001

H. Dong, K. Fink, R. Ust, S. P. Lim, C. Qin et al., Flavivirus RNA methylation, Journal of General Virology, vol.95, issue.Pt_4, pp.763-778, 2014.
DOI : 10.1099/vir.0.062208-0

M. Issur, B. J. Geiss, I. Bougie, F. Picard-jean, S. Despins et al., The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure, RNA, vol.15, issue.12, pp.2340-2350, 2009.
DOI : 10.1261/rna.1609709

M. Nomaguchi, M. Ackermann, C. Yon, S. You, and R. Padmanbhan, De Novo Synthesis of Negative-Strand RNA by Dengue Virus RNA-Dependent RNA Polymerase In Vitro: Nucleotide, Primer, and Template Parameters, Journal of Virology, vol.77, issue.16, pp.8831-8842, 2003.
DOI : 10.1128/JVI.77.16.8831-8842.2003

B. Selisko, H. Dutartre, J. Guillemot, C. Debarnot, D. Benarroch et al., Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases, Virology, vol.351, issue.1, pp.145-158, 2006.
DOI : 10.1016/j.virol.2006.03.026

N. Scrima, C. Caillet-saguy, M. Ventura, D. Harrus, T. Astier-gin et al., Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405, Journal of Virology, vol.86, issue.13, pp.7107-7117, 2012.
DOI : 10.1128/JVI.00459-12

B. Selisko, S. Potisopon, R. Agred, S. Priet, I. Varlet et al., Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome, PLoS Pathogens, vol.8, issue.9, p.1002912, 2012.
DOI : 10.1371/journal.ppat.1002912.g008

URL : https://hal.archives-ouvertes.fr/hal-00733199

H. Malet, M. Egloff, B. Selisko, R. E. Butcher, P. J. Wright et al., Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5, Journal of Biological Chemistry, vol.282, issue.14, pp.10678-10689, 2007.
DOI : 10.1074/jbc.M607273200

B. Zhang, H. Dong, Y. Zhou, and P. Shi, Genetic Interactions among the West Nile Virus Methyltransferase, the RNA-Dependent RNA Polymerase, and the 5' Stem-Loop of Genomic RNA, Journal of Virology, vol.82, issue.14, pp.7047-7058, 2008.
DOI : 10.1128/JVI.00654-08

C. S. Tan, J. M. Hobson-peters, M. J. Stoermer, D. P. Fairlie, A. A. Khromykh et al., An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein, Journal of General Virology, vol.94, issue.Pt_9, pp.1961-1971, 2013.
DOI : 10.1099/vir.0.054395-0

H. Dong, D. C. Chang, M. H. Hua, S. P. Lim, Y. H. Chionh et al., 2???-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase, PLoS Pathogens, vol.286, issue.4, p.1002642, 2012.
DOI : 10.1371/journal.ppat.1002642.g007

C. V. Filomatori, N. G. Iglesias, S. M. Villordo, D. E. Alvarez, and A. Gamarnik, RNA Sequences and Structures Required for the Recruitment and Activity of the Dengue Virus Polymerase, Journal of Biological Chemistry, vol.286, issue.9, pp.6929-6939, 2011.
DOI : 10.1074/jbc.M110.162289

D. R. Latour, A. Jekle, H. Javanbakht, R. Henningsen, P. Gee et al., Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2???-ethynyl-7-deaza-adenosine triphosphate, Antiviral Research, vol.87, issue.2, pp.213-222, 2010.
DOI : 10.1016/j.antiviral.2010.05.003

T. L. Yap, T. Xu, Y. Chen, H. Malet, M. Egloff et al., Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution, Journal of Virology, vol.81, issue.9, pp.4753-4765, 2007.
DOI : 10.1128/JVI.02283-06

P. Surana, V. Satchidanandam, and D. T. Nair, RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state, Nucleic Acids Research, vol.42, issue.4, pp.2758-2773, 2014.
DOI : 10.1093/nar/gkt1106

S. Potisopon, S. Priet, B. Selisko, and B. Canard, Comparison of dengue virus??and HCV: from impact on global health to their RNA-dependent RNA polymerases, Future Virology, vol.9, issue.1, pp.53-67, 2014.
DOI : 10.2217/fvl.13.121

C. Bussetta and K. H. Choi, Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution, Biochemistry, vol.51, issue.30, pp.5921-5931, 2012.
DOI : 10.1021/bi300406n

S. You and R. Padmanabhan, A Novel in Vitro Replication System for Dengue Virus: INITIATION OF RNA SYNTHESIS AT THE 3'-END OF EXOGENOUS VIRAL RNA TEMPLATES REQUIRES 5'- AND 3'-TERMINAL COMPLEMENTARY SEQUENCE MOTIFS OF THE VIRAL RNA, Journal of Biological Chemistry, vol.274, issue.47, pp.33714-33722, 1999.
DOI : 10.1074/jbc.274.47.33714

M. Ackermann and R. Padmanabhan, De Novo Synthesis of RNA by the Dengue Virus RNA-dependent RNA Polymerase Exhibits Temperature Dependence at the Initiation but Not Elongation Phase, Journal of Biological Chemistry, vol.276, issue.43, pp.39926-39937, 2001.
DOI : 10.1074/jbc.M104248200

T. Schwede, SWISS-MODEL: an automated protein homology-modeling server, Nucleic Acids Research, vol.31, issue.13, pp.3381-3385, 2003.
DOI : 10.1093/nar/gkg520

URL : http://doi.org/10.1093/nar/gkg520

M. Egloff, D. Benarroch, B. Selisko, J. Romette, and B. Canard, An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization, The EMBO Journal, vol.21, issue.11, pp.2757-2768, 2002.
DOI : 10.1093/emboj/21.11.2757

S. P. Lim, J. H. Koh, C. C. Seh, C. W. Liew, A. D. Davidson et al., A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities, Journal of Biological Chemistry, vol.288, issue.43, pp.31105-31114, 2013.
DOI : 10.1074/jbc.M113.508606

L. Yu, K. Takeda, and L. Markoff, Protein???protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells, Virology, vol.446, issue.1-2, pp.365-377, 2013.
DOI : 10.1016/j.virol.2013.08.006

K. Li, W. W. Phoo, and D. Luo, Functional interplay among the flavivirus NS3 protease, helicase, and cofactors, Virologica Sinica, vol.286, issue.2, pp.74-85, 2014.
DOI : 10.1007/s12250-014-3438-6

L. Breton, M. Meyniel-schicklin, L. Deloire, A. Coutard, B. Canard et al., Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen, BMC Microbiology, vol.11, issue.1, p.234, 2011.
DOI : 10.1006/viro.1996.0307

URL : https://hal.archives-ouvertes.fr/inserm-00703154

M. Johansson, A. J. Brooks, D. A. Jans, and S. G. Vasudevan, A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-?? and the viral helicase, NS3, Journal of General Virology, vol.82, issue.4, pp.735-745, 2001.
DOI : 10.1099/0022-1317-82-4-735

G. Zou, Y. Chen, H. Dong, C. C. Lim, L. J. Yap et al., Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase, Journal of Biological Chemistry, vol.286, issue.16, pp.14362-14372, 2011.
DOI : 10.1074/jbc.M110.214189