Growth hormone level at admission and its evolution during refeeding are predictive of short-term outcome in restrictive anorexia nervosa

Jp Nogueira (1) , René Valéro (1) , Marie Maraninchi (2) , Anne Marie Lorec (3) , Catherine Samuelian-Massat (1) , Audrey Bégu-Le Corroller (4) , Alain Nicolay (5, 3) , Jean Gaudart (6, 7) , Henri Portugal (2) , Bernard Vialettes (2)

1 Maladies Métaboliques et Endocrinologie
2 NORT - Nutrition, obésité et risque thrombotique
3 Département de biochimie
4 Service d'endocrinologie, diabète et maladies métaboliques
5 Nutriments Lipidiques et Prévention des Maladies Métaboliques
6 SESSTIM - U912 INSERM - Aix Marseille Univ - IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
7 AMU - Aix Marseille Université

The growth hormone (GH)– insulin-like growth factor-1 (IGF-1) axis is dramatically altered in patients with anorexia nervosa (AN). The aim of the present study was to investigate whether GH and IGF-1 could be predictors of outcome in patients with a restrictive form of AN. Blood levels of GH, IGF-1, adipocytokines, ghrelin, insulin, glucose, and sex and thyroid hormones were measured in eleven women inpa-tients with AN and in ten healthy women controls. Three stages were compared during refeeding: admission (T0), when BMI reached 16 kg/m 2 (T1) and at discharge when BMI reached 17·5 kg/m 2 (T2). Clinical status was assessed 6 months after discharge from hospital (T3), and remission was defined by the maintenance of a BMI $ 17·5 kg/m

Keywords: Anorexia nervosa; Growth hormone; Insulin-like growth factor-1; EATING-DISORDERS; BINDING PROTEIN; SECRETION; RECOVERY

Keywords: Outcomes; NUTRITIONAL-STATUS; ADOLESCENTS; LEPTIN

Domains: Mathematics [math]; Dynamical Systems [math.DS]; Mathematics [math]; Probability [math.PR]; Statistics [stat]; Applications [stat.AP]; Statistics [stat]; Methodology [stat.ME]; Mathematics [math]; Statistics [math.ST]; Environmental Sciences; Environmental and Society; Life Sciences [q-bio]; Ecology, environment; Health; Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Santé publique et épidémiologie

Jp Nogueira, René Valéro, Marie Maraninchi, Anne Marie Lorec, Catherine Samuelian-Massat, et al.. Growth hormone level at admission and its evolution during refeeding are predictive of short-term outcome in restrictive anorexia nervosa. British Journal of Nutrition, 2013, 109 (12), pp.2175 - 2181. ⟨10.1017/S000711451200431X⟩. ⟨hal-01307680⟩