N. Chandel, D. Mcclintock, C. Feliciano, T. Wood, A. Melendez et al., Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1?? during Hypoxia: A MECHANISM OF O2 SENSING, Journal of Biological Chemistry, vol.275, issue.33, pp.25130-25138, 2000.
DOI : 10.1074/jbc.M001914200

K. Tormos, H. Anso, R. Hamanaka, J. Eisenbart, J. Joseph et al., Mitochondrial Complex III ROS Regulate Adipocyte Differentiation, Cell Metabolism, vol.14, issue.4, pp.537-544, 2011.
DOI : 10.1016/j.cmet.2011.08.007

Y. Wang, Q. Zang, Z. Liu, Q. Wu, D. Maass et al., Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species, AJP: Cell Physiology, vol.301, issue.3, pp.695-704, 2011.
DOI : 10.1152/ajpcell.00322.2010

N. Khawaja, M. Carré, H. Kovacic, M. Estève, and D. Braguer, Patupilone-Induced Apoptosis Is Mediated by Mitochondrial Reactive Oxygen Species through Bim Relocalization to Mitochondria, Molecular Pharmacology, vol.74, issue.4, pp.1072-1083, 2008.
DOI : 10.1124/mol.108.048405

J. Franklin, Redox Regulation of the Intrinsic Pathway in Neuronal Apoptosis, Antioxidants & Redox Signaling, vol.14, issue.8, pp.1437-1448, 2011.
DOI : 10.1089/ars.2010.3596

S. Wu, F. Zhou, Z. Zhang, and D. Xing, Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins, FEBS Journal, vol.17, issue.6, pp.941-954, 2011.
DOI : 10.1111/j.1742-4658.2011.08010.x

S. Lefevre, D. Sliwa, R. P. Camadro, J. Santos, and R. , Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells, Biochemical and Biophysical Research Communications, vol.418, issue.2, pp.336-341, 2012.
DOI : 10.1016/j.bbrc.2012.01.022

URL : https://hal.archives-ouvertes.fr/hal-00665202

S. Ralph, S. Rodriguez-enriquez, J. Neuzil, and R. Moreno-sanchez, Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger, Molecular Aspects of Medicine, vol.31, issue.1, pp.29-59, 2010.
DOI : 10.1016/j.mam.2009.12.006

V. Gogvadze, Targeting Mitochondria in Fighting Cancer, Current Pharmaceutical Design, vol.17, issue.36, pp.4034-4046, 2011.
DOI : 10.2174/138161211798764933

M. Esteve, M. Carré, and D. Braguer, Microtubules in apoptosis induction: are they necessary? Curr Cancer Drug Targets, pp.713-729, 2007.

A. Rovini, A. Savry, D. Braguer, and M. Carré, Microtubule-targeted agents: When mitochondria become essential to chemotherapy, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1807, issue.6, pp.679-688, 2011.
DOI : 10.1016/j.bbabio.2011.01.001

D. Bufalo, D. Biroccio, A. Trisciuoglio, D. Bruno, T. Floridi et al., Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used, European Journal of Cancer, vol.38, issue.18, pp.2455-2462, 2002.
DOI : 10.1016/S0959-8049(02)00391-X

M. Estève, M. Carré, V. Bourgarel-rey, A. Kruczynski, G. Raspaglio et al., Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine, Molecular Cancer Therapeutics, vol.5, issue.11, pp.2824-2833, 2006.
DOI : 10.1158/1535-7163.MCT-06-0277

A. Savry, M. Carré, R. Bergès, A. Rovini, I. Pobel et al., Bcl-2???Enhanced Efficacy of Microtubule-Targeting Chemotherapy through Bim Overexpression: Implications for Cancer Treatment, Neoplasia, vol.15, issue.1, pp.49-60, 2013.
DOI : 10.1593/neo.121074

N. André, D. Braguer, G. Brasseur, A. Gonçalves, D. Lemesle-meunier et al., Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells, Cancer Res, vol.60, pp.5349-5353, 2000.

G. Varbiro, B. Veres, F. Gallyas, and B. Sumegi, Direct effect of Taxol on free radical formation and mitochondrial permeability transition, Free Radical Biology and Medicine, vol.31, issue.4, pp.548-558, 2001.
DOI : 10.1016/S0891-5849(01)00616-5

S. Honoré, E. Pasquier, and D. Braguer, Understanding microtubule dynamics for improved cancer therapy, Cellular and Molecular Life Sciences, vol.62, issue.24, pp.3039-3056, 2005.
DOI : 10.1007/s00018-005-5330-x

C. Dumontet and M. Jordan, Microtubule-binding agents: a dynamic field of cancer therapeutics, Nature Reviews Drug Discovery, vol.25, issue.10, pp.790-803, 2010.
DOI : 10.1038/nrd3253

URL : https://hal.archives-ouvertes.fr/inserm-00526519

E. Balzer, Z. Tong, C. Paul, W. Hung, K. Stroka et al., Physical confinement alters tumor cell adhesion and migration phenotypes, The FASEB Journal, vol.26, issue.10, pp.4045-4056, 2012.
DOI : 10.1096/fj.12-211441

X. Sun, D. Li, Y. Yang, Y. Ren, J. Li et al., Microtubule-binding protein CLIP-170 is a

J. Wang, X. Zhou, H. Zhu, S. Liu, C. Zhou et al., Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating ??-catenin/TCF pathway, Oncogene, vol.11, issue.44, pp.6637-6645, 2005.
DOI : 10.1002/ijc.20642

X. Dong, F. Liu, L. Sun, M. Liu, D. Li et al., Oncogenic function of microtubule endbinding protein 1 in breast cancer, J Pathol, vol.220, issue.3, pp.361-369, 2010.

S. Honoré, A. Pagano, G. Gauthier, V. Bourgarel-rey, P. Verdier-pinard et al., Antiangiogenic vinflunine affects EB1 localization and microtubule targeting to adhesion sites, Molecular Cancer Therapeutics, vol.7, issue.7, pp.2080-2089, 2008.
DOI : 10.1158/1535-7163.MCT-08-0156

A. Rovini, M. Carré, T. Bordet, R. Pruss, and D. Braguer, Olesoxime prevents microtubule-targeting drug neurotoxicity: Selective preservation of EB comets in differentiated neuronal cells, Biochemical Pharmacology, vol.80, issue.6, pp.884-894, 2010.
DOI : 10.1016/j.bcp.2010.04.018

A. Pagano, S. Honoré, R. Mohan, R. Bergès, A. Akhmanova et al., Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends, Biochemical Pharmacology, vol.84, issue.4, pp.432-443, 2012.
DOI : 10.1016/j.bcp.2012.05.010

Y. Komarova, F. Huang, M. Geyer, N. Daneshjou, A. Garcia et al., VE-Cadherin Signaling Induces EB3 Phosphorylation to Suppress Microtubule Growth and Assemble Adherens Junctions, Molecular Cell, vol.48, issue.6, pp.914-925, 2013.
DOI : 10.1016/j.molcel.2012.10.011

J. Ferreira, A. Pereira, A. Akhmanova, and H. Maiato, Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis, The Journal of Cell Biology, vol.55, issue.5, pp.709-724, 2013.
DOI : 10.1083/jcb.201301131.dv

J. Zumbrunn, K. Kinoshita, A. Hyman, and I. Näthke, Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3?? phosphorylation, Current Biology, vol.11, issue.1, pp.44-49, 2001.
DOI : 10.1016/S0960-9822(01)00002-1

A. Nakano, H. Kato, T. Watanabe, K. Min, S. Yamazaki et al., AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation, Nature Cell Biology, vol.16, issue.6, pp.583-590, 2010.
DOI : 10.1038/ncb2060

T. Zimniak, K. Stengl, K. Mechtler, and S. Westermann, Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p, The Journal of Cell Biology, vol.6, issue.3, pp.379-391, 2009.
DOI : 10.1091/mbc.E07-06-0536

M. Limori, K. Ozaki, Y. Chikashige, T. Habu, Y. Hiraoka et al., A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules, Exp Cell Res, vol.318, issue.3, pp.262-275, 2012.

J. Smith, T. Hong, D. Gao, J. Vogan, B. Jensen et al., Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium, Journal of Clinical Investigation, vol.120, issue.1, pp.266-279, 2010.
DOI : 10.1172/JCI39740DS1

N. Tamura and V. Draviam, Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles, Open Biology, vol.13, issue.1, p.120132, 2012.
DOI : 10.1016/j.devcel.2011.01.008

J. Tirnauer, S. Grego, E. Salmon, and T. Mitchison, EB1-Microtubule Interactions in Xenopus Egg Extracts: Role of EB1 in Microtubule Stabilization and Mechanisms of Targeting to Microtubules, Molecular Biology of the Cell, vol.13, issue.10, pp.3614-3626, 2002.
DOI : 10.1091/mbc.02-04-0210

K. Busch and D. Brunner, The Microtubule Plus End-Tracking Proteins mal3p and tip1p Cooperate for Cell-End Targeting of Interphase Microtubules, Current Biology, vol.14, issue.7, pp.548-559, 2004.
DOI : 10.1016/j.cub.2004.03.029

P. Xia, Z. Wang, X. Liu, B. Wu, J. Wang et al., EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis, Proceedings of the National Academy of Sciences, vol.109, issue.41, pp.16564-16569, 2012.
DOI : 10.1073/pnas.1202639109

A. Rovini, G. Gauthier, R. Berges, A. Kruczynski, D. Braguer et al., Anti-Migratory Effect of Vinflunine in Endothelial and Glioblastoma Cells Is Associated with Changes in EB1 C-Terminal Detyrosinated/Tyrosinated Status, PLoS ONE, vol.71, issue.6, p.65694, 2013.
DOI : 10.1371/journal.pone.0065694.s003

URL : https://hal.archives-ouvertes.fr/hal-01406320

Y. Komarova, D. Groot, C. Grigoriev, I. Gouveia, S. Munteanu et al., Mammalian end binding proteins control persistent microtubule growth, The Journal of Cell Biology, vol.112, issue.Pt 14, pp.691-706, 2009.
DOI : 10.1016/j.neuron.2004.05.011

R. Ban, H. Matsuzaki, T. Akashi, G. Sakashita, H. Tanigushi et al., Mitotic Regulation of the Stability of Microtubule Plus-end Tracking Protein EB3 by Ubiquitin Ligase SIAH-1 and Aurora Mitotic Kinases, Journal of Biological Chemistry, vol.284, issue.41, pp.28367-28381, 2009.
DOI : 10.1074/jbc.M109.000273

S. Etienne-manneville, APC in Cell Migration, Adv Exp Med Biol, vol.656, pp.30-40, 2009.
DOI : 10.1007/978-1-4419-1145-2_3

D. Linseman, B. Butts, T. Precht, R. Phelps, S. Le et al., Glycogen Synthase Kinase-3?? Phosphorylates Bax and Promotes Its Mitochondrial Localization during Neuronal Apoptosis, Journal of Neuroscience, vol.24, issue.44, pp.9993-10002, 2004.
DOI : 10.1523/JNEUROSCI.2057-04.2004

U. Maurer, C. Charvet, A. Wagman, E. Dejardin, and D. Green, Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1, Molecular Cell, vol.21, issue.6, pp.749-760, 2006.
DOI : 10.1016/j.molcel.2006.02.009

B. Stiles, PI-3-K and AKT: Onto the mitochondria???, Advanced Drug Delivery Reviews, vol.61, issue.14, pp.1276-1282, 2009.
DOI : 10.1016/j.addr.2009.07.017

J. Engelman, Targeting PI3K signalling in cancer: opportunities, challenges and limitations, Nature Reviews Cancer, vol.16, issue.8, pp.550-562, 2009.
DOI : 10.1038/nrc2664

W. Alexander, Inhibiting the akt pathway in cancer treatment: three leading candidates, P T, vol.36, issue.4, pp.225-227, 2011.

H. Sun, T. Yu, and J. Li, Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: More than just AKT inhibition, Cancer Letters, vol.310, issue.1, pp.118-128, 2011.
DOI : 10.1016/j.canlet.2011.06.010

K. Almahanna, C. Cubitt, S. Zhang, S. Kazim, K. Husain et al., MK-2206, an Akt inhibitor, enhances carboplatinum/paclitaxel efficacy in gastric cancer cell lines, Cancer Biology & Therapy, vol.31, issue.10, pp.932-936, 2013.
DOI : 10.1158/0008-5472.CAN-09-1947

V. Rebecca, R. Massaro, I. Fedorenko, V. Sondak, A. Anderson et al., Inhibition of autophagy enhances the effects of the Akt inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma, Pigment Cell Melanoma Res, vol.184, issue.5, pp.691-706, 2014.

F. Chiarini, C. Grimaldi, F. Ricci, P. Tazzari, C. Evangelisti et al., Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia, Cancer Research, vol.70, issue.20, pp.8097-8107, 2010.
DOI : 10.1158/0008-5472.CAN-10-1814

M. Manara, G. Nicoletti, D. Zambelli, S. Ventura, C. Guerzoni et al., NVP-BEZ235 as a New Therapeutic Option for Sarcomas, Clinical Cancer Research, vol.16, issue.2, pp.530-540, 2010.
DOI : 10.1158/1078-0432.CCR-09-0816

J. Martindale and N. Holbrook, Cellular response to oxidative stress: Signaling for suicide and survival, Journal of Cellular Physiology, vol.12, issue.1, pp.1-15, 2002.
DOI : 10.1002/jcp.10119

V. Weissig, Mitochondria-Specific Nanocarriers for Improving the Proapoptotic Activity of Small Molecules, Methods Enzymol, vol.508, pp.131-155, 2012.
DOI : 10.1016/B978-0-12-391860-4.00007-0

S. Biswas, N. Dodwadkar, P. Deshpande, and V. Torchilin, Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo, Journal of Controlled Release, vol.159, issue.3, pp.393-402, 2012.
DOI : 10.1016/j.jconrel.2012.01.009

J. Zhou, W. Zhao, X. Ma, R. Ju, X. Li et al., The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer, Biomaterials, vol.34, issue.14, pp.3626-3638, 2013.
DOI : 10.1016/j.biomaterials.2013.01.078

C. Jose and R. Rossignol, Rationale for mitochondria-targeting strategies in cancer bioenergetic therapies, The International Journal of Biochemistry & Cell Biology, vol.45, issue.1, pp.123-129, 2013.
DOI : 10.1016/j.biocel.2012.07.005

C. Jose, E. Hebert-chatelain, N. Bellance, A. Larendra, M. Su et al., AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1807, issue.6, pp.707-718, 2011.
DOI : 10.1016/j.bbabio.2010.12.002

Z. Liu, Y. Zhang, Q. Zhang, S. Zhao, C. Wu et al., 3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-1 through the PI3K/Akt signaling pathway, Anti-Cancer Drugs, vol.25, issue.4, pp.447-455, 2014.
DOI : 10.1097/CAD.0000000000000081

H. Hagland, J. Nikolaisen, L. Hodneland, B. Gjertsen, O. Bruserud et al., Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling, Expert Opinion on Therapeutic Targets, vol.7, issue.8, pp.1055-1069, 2007.
DOI : 10.1083/jcb.200512100

P. Ngamsiri, P. Watcharasit, and J. Satayavivad, Glycogen synthase kinase-3 (GSK3) controls deoxyglucose-induced mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells, Mitochondrion, vol.14, issue.1, pp.54-63, 2014.
DOI : 10.1016/j.mito.2013.11.003