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Efficiency and safety of five procedures for percutaneous native kidney biopsy: a multicentric comparative study.

Abstract : Abstract Background and objectives Renal biopsy(RB) is necessary for the diagnosis, prognosis, and therapy guidance of native kidney diseases. Few studies have compared outcomes of RB procedures. We compared the efficiency and safety of five biopsy procedures. Design, setting, participants, and measurements Number of glomeruli on light microscopy(LM) and on immunofluorescence(IF) and serious adverse events following RB performed in five nephrology units(C1-C5) were retrospectively collected. C1 performed ultrasound assessment before RB and used a 14-gauge core-cutting needle biopsy gun, C2 ultrasound guidance and a 14-gauge needle, C3 tomodensitometry guidance and a 14-gauge needle, C4 ultrasound guidance and a 16-gauge needle, and C5 tomodensitometry guidance and a 16-gauge needle. Results Data from 943 RB performed between January 2006 and July 2010 were collected (C1: 408; C2: 254; C3: 81; C4: 136; C5: 64). On LM, mean number of glomeruli on biopsy core was 14.2±8.6. It was higher in C1 and C2 than in C3, C4, and C5(p=0.01). At least 10 glomeruli were found in 69% of biopsies. This rate was higher in C1 and C2 than in C3, C4, and C5(p=0.004). On IF, mean number of glomeruli was 4.4±3.3. It was higher in C1 and C2 than in C3, C4, and C5(p<0.001). In multivariate analysis, the only factor that influenced number of glomeruli on LM(p=0.004) and IF(p=0.004) was the nephrology unit. Serious adverse events occurred in 1.5% of biopsies. Complication rate was not different between nephrology units. Conclusions RB is safe but radiological guidance, needle-size, and experience influence the quality of biopsies.
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Stanislas Bataille, Laurent Daniel, Jean Mondain, Magali Faure, Pierre Gobert, et al.. Efficiency and safety of five procedures for percutaneous native kidney biopsy: a multicentric comparative study.. American Journal of Nephrology, Karger, 2012, 35 (5), pp.387 - 393. ⟨10.1159/000337932⟩. ⟨hal-01313301⟩

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