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Combining Organocatalysis with Central-to-Axial Chirality Conversion: Atroposelective Hantzsch-Type Synthesis of 4-Arylpyridines

Abstract : Suitably substituted enantioenriched 4-aryl-1,4-dihydro-pyridines prepared by an organocatalytic enantioselective Michael addition were oxidized with MnO2 into axially chiral 4-arylpyridines with central-to-axial chirality conversion. Moderate to complete conversion percentages (cp) were observed, and a model for the conversion of chirality is discussed.
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https://hal.archives-ouvertes.fr/hal-01323419
Contributor : Gaelle Chouraqui Connect in order to contact the contributor
Submitted on : Monday, May 30, 2016 - 2:47:28 PM
Last modification on : Tuesday, December 14, 2021 - 8:36:12 AM

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Ophélie Quinonero, Marion Jean, Nicolas Vanthuyne, Christian Roussel, Damien Bonne, et al.. Combining Organocatalysis with Central-to-Axial Chirality Conversion: Atroposelective Hantzsch-Type Synthesis of 4-Arylpyridines. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2016, 55, ⟨10.1002/anie.201509967⟩. ⟨hal-01323419⟩

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