Didecarboxylative Iron-Catalyzed Bidirectional Aldolization towards Diversity-Oriented Ketodiol Synthesis.

Adrien Quintard (1) , Jean Rodriguez (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

1,3-Acetonedicarboxylic acid was selectively ac-tivated by Fe(acac)3, providing a synthetic platform forrapid synthesis of keto-3,3’-diols. The bidirectional aldol reaction was efficient for challenging aliphatic aldehydes,providing a rapid route to potentially bioactive complex structures

Keywords: Aldolization; decarboxylation; homogeneouscatalysis; iron; polyols

Domains: Organic chemistry

Adrien Quintard, Jean Rodriguez. Didecarboxylative Iron-Catalyzed Bidirectional Aldolization towards Diversity-Oriented Ketodiol Synthesis.. Chemistry - A European Journal, 2015, pp.14717. ⟨10.1002/chem.201502788⟩. ⟨hal-01323440⟩