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Time-Efficient Synthesis of Pyrido[2,3-d]pyrimidinones via α-Oxoketenes

Abstract : α-Oxoketene reactive intermediates generated in situ by microwave-assisted Wolff rearrangement of 2-diazo-1,3- dicarbonyl compounds have been found to react with 6-amino-pyrimidine derivatives as 1,3-C,N-bis-nucleophiles to yield pyrido[2,3-d]pyrimidinones and related compounds amenable to further functionalization.
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https://hal.archives-ouvertes.fr/hal-01323463
Contributor : Gaelle Chouraqui Connect in order to contact the contributor
Submitted on : Monday, May 30, 2016 - 3:03:17 PM
Last modification on : Tuesday, December 14, 2021 - 8:36:12 AM

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Juan Carlos Castillo, Jairo Quiroga, Jean Rodriguez, Yoann Coquerel. Time-Efficient Synthesis of Pyrido[2,3-d]pyrimidinones via α-Oxoketenes. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2016, pp.1994-1999. ⟨10.1002/ejoc.201600171⟩. ⟨hal-01323463⟩

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