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Extreme multifunctional proteins identified from a human protein interaction network.

Abstract : Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme multifunctional' proteins from an interactome as a first step to characterize moonlighting proteins. By combining network topological information with protein annotations, we identify 430 extreme multifunctional proteins (3% of the human interactome). We show that the candidates form a distinct subgroup of proteins, characterized by specific features, which form a signature of extreme multi-functionality. Overall, extreme multifunctional proteins are enriched in linear motifs and less intrinsically disordered than network hubs. We also provide MoonDB, a database containing information on all the candidates identified in the analysis and a set of manually curated human moonlighting proteins.
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Charles E Chapple, Benoît Robisson, Lionel Spinelli, Celine Guien, Becker Emmanuelle, et al.. Extreme multifunctional proteins identified from a human protein interaction network.. Nature Communications, Nature Publishing Group, 2015, 6 (1), pp.7412. ⟨10.1038/ncomms8412⟩. ⟨hal-01407399⟩

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