J. Hinson, S. Kapas, and D. Smith, Adrenomedullin, a Multifunctional Regulatory Peptide, Endocrine Reviews, vol.21, issue.2, pp.138-167, 2000.
DOI : 10.1210/er.21.2.138

L. Mclatchie, F. N. Main, M. Wise, A. Brown, J. Thompson et al., RAMPs regulate the transport and ligand specificity of the calcitoninreceptor-like receptor, Nature, vol.393, pp.333-339, 1998.

D. Poyner, P. Sexton, I. Marshall, D. Smith, R. Quirion et al., International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors, Pharmacological Reviews, vol.54, issue.2, pp.233-246, 2002.
DOI : 10.1124/pr.54.2.233

K. Caron and O. Smithies, Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene, Proceedings of the National Academy of Sciences, vol.98, issue.2, pp.615-619, 2001.
DOI : 10.1073/pnas.98.2.615

T. Shindo, Y. Kurihara, H. Nishimatsu, N. Moriyama, M. Kakoki et al., Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene, Circulation, vol.104, issue.16, pp.1964-1971, 2001.
DOI : 10.1161/hc4101.097111

R. Dackor, K. Fritz-six, W. Dunworth, C. Gibbons, O. Smithies et al., Hydrops Fetalis, Cardiovascular Defects, and Embryonic Lethality in Mice Lacking the Calcitonin Receptor-Like Receptor Gene, Molecular and Cellular Biology, vol.26, issue.7, pp.2511-2518, 2006.
DOI : 10.1128/MCB.26.7.2511-2518.2006

Y. Ichikawa-shindo, T. Sakurai, A. Kamiyoshi, H. Kawate, N. Iinuma et al., The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity, Journal of Clinical Investigation, vol.118, issue.1, pp.29-39, 2008.
DOI : 10.1172/JCI33022

K. Fritz-six, W. Dunworth, M. Li, and K. Caron, Adrenomedullin signaling is necessary for murine lymphatic vascular development, Journal of Clinical Investigation, vol.118, issue.1, pp.40-50, 2008.
DOI : 10.1172/JCI33302DS1
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147672

R. Dackor, K. Fritz-six, O. Smithies, and K. Caron, Receptor Activity-modifying Proteins 2 and 3 Have Distinct Physiological Functions from Embryogenesis to Old Age, Journal of Biological Chemistry, vol.282, issue.25, pp.18094-18099, 2007.
DOI : 10.1074/jbc.M703544200

T. Czyzyk, Y. Ning, M. Hsu, B. Peng, R. Mains et al., Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse, Developmental Biology, vol.287, issue.2, pp.301-313, 2005.
DOI : 10.1016/j.ydbio.2005.09.001

E. Zudaire, A. Martinez, and F. Cuttitta, Adrenomedullin and cancer, Regulatory Peptides, vol.112, issue.1-3, pp.175-183, 2003.
DOI : 10.1016/S0167-0115(03)00037-5

M. Miller, A. Martinez, E. Unsworth, C. Thiele, T. Moody et al., Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor, J Biol Chem, vol.271, pp.23345-23351, 1996.

L. Ouafik, S. Sauze, F. Boudouresque, O. Chinot, C. Delfino et al., Neutralization of Adrenomedullin Inhibits the Growth of Human Glioblastoma Cell Lines in Vitro and Suppresses Tumor Xenograft Growth in Vivo, The American Journal of Pathology, vol.160, issue.4, pp.1279-1292, 2002.
DOI : 10.1016/S0002-9440(10)62555-2
URL : https://hal.archives-ouvertes.fr/inserm-00151079

E. Nouguerede, C. Berenguer, S. Garcia, B. Bennanni, C. Delfino et al., Expression of adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenograft growth in vivo, Cancer Medicine, vol.91, issue.Suppl. 1, pp.196-207, 2013.
DOI : 10.1002/cam4.51

C. Berenguer-daizé, F. Boudouresque, C. Bastide, A. Tounsi, Z. Benyahia et al., Adrenomedullin Blockade Suppresses Growth of Human Hormone-Independent Prostate Tumor Xenograft in Mice, Clinical Cancer Research, vol.19, issue.22, pp.6138-6150, 2013.
DOI : 10.1158/1078-0432.CCR-13-0691

T. Ishikawa, J. Chen, J. Wang, F. Okada, T. Sugiyama et al., Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis, Oncogene, vol.22, issue.8, pp.1238-1242, 2003.
DOI : 10.1038/sj.onc.1206207

I. Kaafarani, S. Fernandez-sauze, C. Berenguer, O. Chinot, C. Delfino et al., Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice, The FASEB Journal, vol.23, issue.10, pp.3424-3435, 2009.
DOI : 10.1096/fj.08-127852

V. Ramachandran, T. Arumugam, R. Hwang, J. Greenson, D. Simeone et al., Adrenomedullin Is Expressed in Pancreatic Cancer and Stimulates Cell Proliferation and Invasion in an Autocrine Manner via the Adrenomedullin Receptor, ADMR, Cancer Research, vol.67, issue.6, pp.2666-2675, 2007.
DOI : 10.1158/0008-5472.CAN-06-3362

E. Dejana, Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis., Journal of Clinical Investigation, vol.98, issue.9, pp.1949-1953, 1996.
DOI : 10.1172/JCI118997

L. Caveda, I. Martin-padura, P. Navarro, F. Breviario, M. Corada et al., Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin)., Journal of Clinical Investigation, vol.98, issue.4, pp.886-893, 1996.
DOI : 10.1172/JCI118870

P. Carmeliet, M. Lampugnani, L. Moons, F. Breviario, V. Compernolle et al., Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis, Cell, vol.98, issue.2, pp.147-157, 1999.
DOI : 10.1016/S0092-8674(00)81010-7

M. Corada, M. Mariotti, G. Thurston, K. Smith, R. Kunkel et al., Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo, Proceedings of the National Academy of Sciences, vol.96, issue.17, pp.9815-9820, 1999.
DOI : 10.1073/pnas.96.17.9815

S. Thomas and J. Brugge, CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES, Annual Review of Cell and Developmental Biology, vol.13, issue.1, pp.513-609, 1997.
DOI : 10.1146/annurev.cellbio.13.1.513

G. Martin, The hunting of the Src, Nature Reviews Molecular Cell Biology, vol.20, issue.6, pp.467-475, 2001.
DOI : 10.1038/35073094

P. Cowin and B. Burke, Cytoskeleton???membrane interactions, Current Opinion in Cell Biology, vol.8, issue.1, pp.56-65, 1996.
DOI : 10.1016/S0955-0674(96)80049-4

L. Shapiro, A. Fannon, P. Kwong, A. Thompson, M. Lehmann et al., Structural basis of cell-cell adhesion by cadherins, Nature, vol.374, issue.6520, pp.327-337, 1995.
DOI : 10.1038/374327a0

H. Kato, M. Shichiri, F. Marumo, and Y. Hirata, Adrenomedullin as an Autocrine/Paracrine Apoptosis Survival Factor for Rat Endothelial Cells, Endocrinology, vol.138, issue.6, pp.2615-2620, 1997.
DOI : 10.1210/en.138.6.2615

J. Kato, T. Tsuruda, T. Kita, K. Kitamura, and T. Eto, Adrenomedullin: A Protective Factor for Blood Vessels, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.25, issue.12, pp.2480-2487, 2005.
DOI : 10.1161/01.ATV.0000184759.91369.f8

S. Fernandez-sauze, C. Delfino, K. Mabrouk, C. Dussert, O. Chinot et al., Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis: Involvement of CRLR/RAMP2 and CRLR/RAMP3 receptors, International Journal of Cancer, vol.88, issue.6, pp.797-804, 2004.
DOI : 10.1002/ijc.11663

S. Esser, M. Lampugnani, M. Corada, E. Dejana, and W. Risau, Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells, J Cell Sci, vol.111, pp.1853-65, 1998.

B. Gumbiner, Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis, Cell, vol.84, issue.3, pp.345-357, 1996.
DOI : 10.1016/S0092-8674(00)81279-9

P. Andriopoulou, P. Navarro, A. Zanetti, M. Lampugnani, and E. Dejana, Histamine Induces Tyrosine Phosphorylation of Endothelial Cell-to-Cell Adherens Junctions, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.19, issue.10, pp.2286-2297, 1999.
DOI : 10.1161/01.ATV.19.10.2286

S. Roura, S. Miravet, J. Piedra, G. De-herreros, A. Dunach et al., Regulation of E-cadherin/Catenin Association by Tyrosine Phosphorylation, Journal of Biological Chemistry, vol.274, issue.51, pp.36734-36774, 1999.
DOI : 10.1074/jbc.274.51.36734

S. Weis, S. Shintani, A. Weber, R. Kirchmair, M. Wood et al., Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction, Journal of Clinical Investigation, vol.113, issue.6, pp.885-94, 2004.
DOI : 10.1172/JCI200420702

K. Orford, C. Crockett, J. Jensen, A. Weissman, and S. Byers, Serine Phosphorylation-regulated Ubiquitination and Degradation of ??-Catenin, Journal of Biological Chemistry, vol.272, issue.40, pp.24735-24773, 1997.
DOI : 10.1074/jbc.272.40.24735

C. Liu, Y. Kato, Z. Zhang, V. Do, and B. Yankner, ??-Trcp couples ??-catenin phosphorylation-degradation and regulates Xenopus axis formation, Proceedings of the National Academy of Sciences, vol.96, issue.11, pp.6273-6278, 1999.
DOI : 10.1073/pnas.96.11.6273

B. Eliceiri, R. Paul, P. Schwartzberg, J. Hood, J. Leng et al., Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability, Molecular Cell, vol.4, issue.6, pp.915-924, 1999.
DOI : 10.1016/S1097-2765(00)80221-X

W. Kim, S. Moon, M. Sung, S. Kim, S. Lee et al., Angiogenic role of adrenomedullin through activation of Akt, mitogen-activated protein kinase, and focal adhesion kinase in endothelial cells, The FASEB Journal, vol.17, pp.1937-1949, 2003.
DOI : 10.1096/fj.02-1209fje

H. Nishimatsu, E. Suzuki, D. Nagata, N. Moriyama, H. Satonaka et al., Adrenomedullin Induces Endothelium-Dependent Vasorelaxation via the Phosphatidylinositol 3-Kinase/Akt-Dependent Pathway in Rat Aorta, Circulation Research, vol.89, issue.1, pp.63-70, 2001.
DOI : 10.1161/hh1301.092498

K. Miyashita, H. Itoh, N. Sawada, Y. Fukunaga, M. Sone et al., Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo, FEBS Letters, vol.53, issue.1-3, pp.86-92, 2003.
DOI : 10.1016/S0014-5793(03)00484-8

D. Sackett, L. Ozbun, E. Zudaire, L. Wessner, J. Chirgwin et al., Intracellular Proadrenomedullin-Derived Peptides Decorate the Microtubules and Contribute to Cytoskeleton Function, Endocrinology, vol.149, issue.6, pp.2888-2898, 2008.
DOI : 10.1210/en.2007-1763

L. Benjamin, I. Hemo, and E. Keshet, A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF, Development, vol.125, pp.1591-1598, 1998.

M. Potter, S. Barbero, and D. Cheresh, Tyrosine Phosphorylation of VE-cadherin Prevents Binding of p120- and ??-Catenin and Maintains the Cellular Mesenchymal State, Journal of Biological Chemistry, vol.280, issue.36, pp.31906-31912, 2005.
DOI : 10.1074/jbc.M505568200

J. Behrens, L. Vakaet, R. Friis, E. Winterhager, F. Van-roy et al., Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene, The Journal of Cell Biology, vol.120, issue.3, pp.757-766, 1993.
DOI : 10.1083/jcb.120.3.757

R. Nawroth, G. Poell, A. Ranft, S. Kloep, U. Samulowitz et al., VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts, The EMBO Journal, vol.21, issue.18, pp.4885-4895, 2002.
DOI : 10.1093/emboj/cdf497

B. Young, X. Sui, T. Kiser, S. Hyun, P. Wang et al., Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stability, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.285, issue.1, pp.63-75, 2003.
DOI : 10.1152/ajplung.00423.2002

J. Balsamo, T. Leung, H. Ernst, M. Zanin, S. Hoffman et al., Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin, The Journal of Cell Biology, vol.134, issue.3, pp.801-813, 1996.
DOI : 10.1083/jcb.134.3.801

S. Burden-gulley and S. Brady-kalnay, PTP?? Regulates N-Cadherin???dependent Neurite Outgrowth, The Journal of Cell Biology, vol.7, issue.6, pp.1323-1336, 1999.
DOI : 10.1074/jbc.270.24.14247

J. Ukropec, M. Hollinger, S. Salva, and M. Woolkalis, SHP2 Association with VE-Cadherin Complexes in Human Endothelial Cells Is Regulated by Thrombin, Journal of Biological Chemistry, vol.275, issue.8, pp.5983-5986, 2000.
DOI : 10.1074/jbc.275.8.5983

L. Vincent, P. Kermani, L. Young, J. Cheng, F. Zhang et al., Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling, Journal of Clinical Investigation, vol.115, issue.11, pp.2992-3006, 2005.
DOI : 10.1172/JCI24586DS1

F. Liao, Y. Li, O. Connor, W. Zanetta, L. Bassi et al., Monoclonal antibody to vascular endothelialcadherin is a potent inhibitor of angiogenesis, tumor growth, and metastasis, Cancer Res, vol.60, pp.6805-6810, 2000.

F. Liao, J. Doody, J. Overholser, B. Finnerty, R. Bassi et al., Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability, Cancer Res, vol.62, pp.2567-2575, 2002.

D. Viemann, M. Goebeler, S. Schmid, U. Nordhues, K. Klimmek et al., TNF induces distinct gene expression programs in microvascular and macrovascular human endothelial cells, Journal of Leukocyte Biology, vol.80, issue.1, pp.174-185, 2006.
DOI : 10.1189/jlb.0905530

A. Wiktorowska-owczarek, M. Namiecinska, A. Balcerczyk, and J. Nowak, Human micro-and macrovessel-derived endothelial cells: a comparative study on the effects of adrenaline and a selective adenosine A2-type receptor agonist under normoxic and hypoxic conditions, Pharmacol Rep, vol.59, pp.800-806, 2007.

K. Mcquaid, E. Smyth, and A. Keenan, Evidence for modulation of hydrogen peroxide-induced endothelial barrier dysfunction by nitric oxide in vitro, European Journal of Pharmacology, vol.307, issue.2, pp.233-241, 1996.
DOI : 10.1016/0014-2999(96)00271-3