Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance

Inès Abdesselam (1, 2) , Pauline Pepino (1) , Thomas Troalen (1) , Michael Macia (1) , Patricia Ancel , Brice Masi (3) , Natacha Fourny , Benedicte Gaborit (2) , Benoît Giannesini (1) , Frank Kober (1) , Anne Dutour (2, 4) , Monique Bernard (5, 1)

1 CRMBM - Centre de résonance magnétique biologique et médicale
2 NORT - Nutrition, obésité et risque thrombotique
3 GIMP - Génétique et immunologie des maladies parasitaires
4 Service d'Endocrinologie, Maladies Métaboliques et de la Nutrition
5 APHM - Assistance Publique - Hôpitaux de Marseille

Cardiovascular complications of obesity and diabetes are major health problems. Assessing their development, their link with ectopic fat deposition and their flexibility with therapeutic intervention is essential. The aim of this study was to longitudinally investigate cardiac alterations and ectopic fat accumulation associated with diet-induced obesity using multimodal cardiovascular magnetic resonance (CMR) in mice. The second objective was to monitor cardiac response to exendin-4 (GLP-1 receptor agonist).

Keywords: Obesity; Longitudinal study; Proton-magnetic resonance spectroscopy; Cardiovascular magnetic resonance; crmbm; Diabetes; DIO mice model

Domains: Life Sciences [q-bio]; Bioengineering

Inès Abdesselam, Pauline Pepino, Thomas Troalen, Michael Macia, Patricia Ancel, et al.. Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 2015, 17 (1), pp.95. ⟨10.1186/s12968-015-0198-x⟩. ⟨hal-01414315⟩