Copper(I)-Catalysed Multicomponent Reaction: Straightforward Access to 5-Hydroxy-1H-pyrrol-2(5H)-ones

Muhammad Idham Darussalam Mardjan , Jean-Luc Parrain (1) , Laurent Commeiras (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

A copper-catalysed multicomponent coupling reaction between readily available (Z)-3-io-doacrylic acids, terminal alkynes, and primary amines was developed to smoothly access a small library of 5-hydroxy-1H-pyrrol-2(5H)-ones in good yields. This practical and general process was applied to a short-steps synthesis of the natural product pulchellalactam.

Mots clés: copper catalysis; 5-hydroxy-1H-pyrrol- 2(5H)-ones; multicomponent reaction

Domaines: Chimie organique

Muhammad Idham Darussalam Mardjan, Jean-Luc Parrain, Laurent Commeiras. Copper(I)-Catalysed Multicomponent Reaction: Straightforward Access to 5-Hydroxy-1H-pyrrol-2(5H)-ones. Advanced Synthesis and Catalysis, 2016, pp.543. ⟨10.1002/adsc.201500994⟩. ⟨hal-01414941⟩