Organocatalytic Multicomponent Reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles

Haiying Du (1) , Yohan Dudognon (1) , M. del Mar Sanchez Duque (1) , Sébastien Goudedranche (1) , Damien Bonne (1) , Jean Rodriguez (1) , Xavier Bugaut (1) , Thierry Constantieux (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

In this feature article, a general perspective of the research program aimed towards the preparation of polycyclic heterocycles by the means of enantioselective organocatalytic multicomponent reactions is presented. Guidelines for reaction design, including the selection of substrates and organocatalysts are discussed. For all transformations, scope and limitations are presented, along with post-functionalization to afford diversified heterocyclic scaffolds.

Mots clés: 1; 3-dicarbonyls; enantioselectivity; heterocycles; Michael addition; multicomponent reactions; organocatalysis

Domaines: Chimie organique

Haiying Du, Yohan Dudognon, M. del Mar Sanchez Duque, Sébastien Goudedranche, Damien Bonne, et al.. Organocatalytic Multicomponent Reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles. Synthesis: Journal of Synthetic Organic Chemistry, 2016, 48, pp.3479-3503. ⟨10.1055/s-0035-1561490⟩. ⟨hal-01415048⟩