. Allyl, 7-azaspiro[4.5]decane-1,6-dione (8caa) Following the general procedure 2 for substitution, the reaction of spirohemiaminal compound 3ca (170 mg, 0.76 mmol) with allyltrimethylsilane (495 L, 3.07 mmol) and BF 3 ·OEt 2 (95 L, 0.76 mmol) in CH 2 Cl 2 (5 mL) afforded the product 8caa as a white solid (155 mg, 78%). The crude product was obtained with 1:1 dr Data given are for the mixture of two diastereomers

. Allyl, (8daa) Following the general procedure 2 for substitution, the reaction of spirohemiaminal compound 3da (208 mg, 0.59 mmol) with allyltrimethylsilane (382 L, 2.37 mmol) and BF 3 ·OEt 2 (74 L, 0.59 mmol) in CH 2 Cl 2 (5 mL) afforded the product 8daa as a yellow solid (205 mg, 92%). The crude product was obtained with 1:1 dr Data given are for the mixture of two diastereomers

. Hz, 1 H), 3.03 (dd, J = 11.6, 6.3 Hz, 1 H), 2.96 (dd, J = 15, H), 2.33?2.23 (m, 1 H), 2.22?2.12 (m, 1 H), 2.06 (dd, J = 18.6, 2.4 Hz, 1 H), pp.2-3, 2001.

H. Nmr, CDCl 3 ): = 7, MHz, vol.7, issue.59 74

J. =. Hzd, H), 5.80 (ddd, J = 9, pp.7280-7283, 2001.

H. Nmr, CDCl 3 ): = 8, MHz, vol.7, issue.46 75

S. V. Ley, I. R. Baxendale, R. N. Bream, P. S. Jackson, A. G. Leach et al., For some recent reviews, see: (a) Immobilization of Molecular Catalysts, In Handbook of Heterogeneous Catalysis, References Chem. Soc., Perkin Trans. 1 Angew. Chem. Int. Ed. Tetrahedron Chem. Rev. Eur. J. Org. Chem. J. Macromol. Sci. Pure Appl. Chem. Tetrahedron Lett. J. Org. Chem, vol.40, issue.3, pp.3815-650, 1173.

D. Bensa, T. Constantieux, J. Rodriguez, A. Coelho, A. El-maatougui et al., Synthesis, J. L, issue.9, pp.923-3324, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00088055

J. Rodriguez, 1,3-Dicarbonyls in Multicomponent Reactions, In Multicomponent Reactions in Organic Synthesis