Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Brain functional plasticity at rest and during action in multiple sclerosis patients

Abstract : Abstract We aimed to demonstrate that basal functional connectivity reorganization observed in a specific network at rest using resting state functional \MRI\ (rs-fMRI) could be associated with functional cortical reorganization in such network during action (ta-fMRI) in a population of early multiple sclerosis (MS) patients. Altered basal functional connectivity has been previously reported in patients with \MS\ but relationships with cortical reorganization during action have not been explored. Thirteen patients with early relapsing-remitting \MS\ and 14 matched healthy controls were explored on a 3T \MRI\ scanner at rest and during a motor task (conjugate finger flexion and extension movements of each hand). Hand motor networks were extracted from rs-fMRI data using group spatial independent component analysis. For the non-dominant motor network, patients presented a higher basal functional connectivity at rest and recruited a supplementary prefrontal cortical area during action compared to the controls. The levels of hyperconnectivity at rest and of activation in the recruited area during action were significantly correlated. No differences were demonstrated for the dominant motor network at rest and during action. The present study, combining rs-fMRI and ta-fMRI in non-disabled patients with early MS, revealed for the first time a direct association between functional reorganization depicted at rest and during action within the same system.
Keywords : Resting state
Document type :
Journal articles
Complete list of metadata
Contributor : Monique BERNARD Connect in order to contact the contributor
Submitted on : Monday, December 19, 2016 - 3:19:56 PM
Last modification on : Sunday, June 26, 2022 - 12:35:25 PM



Anthony Faivre, Audrey Rico, W Zaaraoui, Francoise Reuter, Sylviane Confort-Gouny, et al.. Brain functional plasticity at rest and during action in multiple sclerosis patients. Journal of Clinical Neuroscience, Elsevier, 2015, 22 (9), pp.1438 -- 1443. ⟨10.1016/j.jocn.2015.02.033⟩. ⟨hal-01419492⟩



Record views